Ask about this productRelated genes to: FKBP11 Blocking Peptide
- Gene:
- FKBP11 NIH gene
- Name:
- FKBP prolyl isomerase 11
- Previous symbol:
- -
- Synonyms:
- FKBP19
- Chromosome:
- 12q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2002-06-05
- Date modifiied:
- 2018-11-01
Related products to: FKBP11 Blocking Peptide
Related articles to: FKBP11 Blocking Peptide
- Medication overuse headache (MOH) causes substantial disability in suffering patients, significantly reducing the quality of life. It may lead to structural and functional brain changes detectable by neuroimaging. Successful and effective treatments can alleviate headache burden, reduce consumption of abused drugs and reverse the biological alterations. Therefore, improvement of therapeutic strategies and optimization of patient stratification to match the individuals who can benefit with certain approaches, is essential. This study investigates DNA methylation (DNAm) associated with response to MOH treatment. - Source: PubMed
Publication date: 2026/04/02
Kwiatkowska Katarzyna MalgorzataFavoni ValentinaFerraresi FrancescaPirazzini ChiaraRavaioli FrancescoBacalini Maria GiuliaDall'Olio DanieleSala ClaudiaCastellani GastoneCalzari LucianoGentilini DavideTerlizzi RossanaPierangeli GiuliaCortelli PietroMascarella DavideGaragnani PaoloCevoli Sabina - The respiratory microbiome, including that of the nasal cavity, is involved in host defense and airway pathophysiology. Interactions of the microbiome with the host immune system may impact health and disease susceptibility through changes in the epigenome. In this study, we aimed to analyze cross-sectional associations of nasal microbiome composition and the nasal epigenome among adolescents in the Project Viva cohort (N = 372, mean age: 13.0 years). We collected nasal swabs from anterior nares, profiled the microbiome by 16 S rRNA gene sequencing, and grouped samples into 6 clusters using partitioning around medoids. Nasal cell DNA methylation was measured with the Illumina MethylationEPIC BeadChip. In an epigenome-wide association study, we tested for associations of microbiome cluster assignment and DNA methylation using robust linear models adjusting sociodemographics, season, batch, and surrogates of cell type composition. Among significant loci, we conducted differential abundance analysis to identify individual bacterial genera associated with DNA methylation levels. - Source: PubMed
Publication date: 2026/02/27
Bozack Anne KPerez-Garcia JavierRifas-Shiman SherylZhou YanjiaoSordillo JoanneLee Jenny JyoungCoull BrentLai Peggy SOken EmilyHivert Marie-FranceGold Diane RCardenas Andres - We developed Standardised Minimum 3D Distance (SM3DD), an entirely cell segmentation/annotation-free approach to the analysis of spatial RNA datasets, using it to compare lung tissue from 16 clinically normal individuals to that of 18 SARS-CoV-2 patients who died from acute respiratory distress syndrome. RNA spatial coordinates were determined using the CosMx™ Spatial Molecular Imager (Bruker Spatial Biology, US). For each individual transcript location, we calculated the three-dimensional distances to the nearest transcript of each transcript type, standardising the distances to each transcript type. Mean SM3DDs were compared between normal and SARS-CoV-2 patients. Notably, hierarchical clustering of the directional log10(P) values organized genes by functionality, making it easier to interpret biological contexts, and for FKBP11, where a decrease in distance to MZT2A was the most significant difference, suggesting a role in interferon signalling. Using a segmented principal components analysis of the entire SM3DD dataset, we identified multiple pathways, including 'SARS-CoV-2 infection', even though the assay did not include any SARS-CoV-2 transcripts. - Source: PubMed
Publication date: 2026/01/27
Blick TonyKilgallon AaronMonkman JamesCooper CarolineTan Chin WeeKillingbeck Emily EPan LiuliuKim YoungmiLiang YanNam AndyLeon MichaelGuimaraes Paulo S FNagashima SeigoMartins Ana P CMachado-Souza Cleberde Noronha LuciaFraser John FBelz Gabrielle TSouza-Fonseca-Guimaraes FernandoKulasinghe Arutha - Anti-N-methyl-D-aspartate receptor encephalitis (NMDAR-E) is an autoimmune disorder often associated with ovarian teratomas. It involves antibodies against the neuronal NMDAr1 subunits of NR1, but the pathogenesis and molecular mechanisms are not fully understood. To identify significantly differentially expressed genes and proteins and investigate the intricate molecular regulatory network underlying anti-NMDA receptor encephalitis (NMDAR-E) associated with ovarian teratomas. - Source: PubMed
Publication date: 2025/12/03
Ma LingweiSun XinmengZhang ShaohuaXiao YinpingGuan HaiyunWang RongminTang ZhijingZhang WeiXia Hexia - Inflammatory bowel disease (IBD) exhibits heterogeneous mucosal inflammation and variable responses to biologics therapy. This study aimed to identify the immune cell subsets and molecular programs driving disease pathogenesis and to develop predictive biomarkers for therapeutic outcomes. - Source: PubMed
Publication date: 2025/11/29
Wu ShanshanLiu ShuangchunZhang CaixiaYu BingqingTan JiaxiongLiu Xiongxiu