Ask about this productRelated genes to: ZPBP2 Blocking Peptide
- Gene:
- ZPBP2 NIH gene
- Name:
- zona pellucida binding protein 2
- Previous symbol:
- -
- Synonyms:
- ZPBPL, MGC41930
- Chromosome:
- 17q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-04-30
- Date modifiied:
- 2015-08-24
Related products to: ZPBP2 Blocking Peptide
Related articles to: ZPBP2 Blocking Peptide
- Natural mating ability is a critical behavioral trait for the reproductive success of captive endangered mammals, and its loss often reflects declining adaptability and potential physiological dysfunctions. However, the underlying molecular regulatory mechanisms remain poorly understood. In this study, we integrated blood transcriptome and whole-genome DNA methylation (whole-genome bisulfite sequencing) data to systematically explore the molecular basis of natural mating ability differences in captive male giant pandas (). A total of 21 male individuals, which were classified into either capable (with successful natural mating experience) or incapable (with repeated mating failure despite physical health) groups, were sampled from three breeding centers. RNA-seq analysis identified key differentially expressed genes (DEGs) such as , enriched in functional pathways related to GnRH signaling, MAPK cascades, immune modulation, and olfactory perception. Whole-genome bisulfite sequencing (WGBS) analysis revealed significant differences in CpG (CG) methylation density on the X chromosome, and identified promoter- and gene body-associated differentially methylated regions (DMRs) that were inversely correlated with gene expression. Integrative analysis demonstrated a strong association between gene expression and DNA methylation, with the associated genes enriched in reproduction-relevant pathways including axon guidance, cysteine and methionine metabolism, and apoptosis/autophagy. These findings suggest that DNA methylation may influence transcriptional activity involved in natural mating behavior. This multi-omics approach provides valuable insights into the epigenetic regulation of complex reproductive phenotypes in endangered species and offers a theoretical basis for future applications in molecular marker-based individual selection and optimization of captive breeding programs, thereby contributing to wildlife conservation efforts. - Source: PubMed
Publication date: 2025/10/12
Yan ZhengLei YinghuZhao PengpengZhang DanhuiShen JienaZhang GuiquanWei RongpingZhang MingyueLiu Dingzhen - Immunoglobulin G (IgG) is the main isotype of antibody in human blood. IgG consists of four subclasses (IgG1 to IgG4), encoded by separate constant region genes within the Ig heavy chain locus (IGH). Here, we report a genome-wide association study on blood IgG subclass levels. Across 4334 adults and 4571 individuals under 18 years, we discover ten new and identify four known variants at five loci influencing IgG subclass levels. These variants also affect the risk of asthma, autoimmune diseases, and blood traits. Seven variants map to the IGH locus, three to the Fcγ receptor (FCGR) locus, and two to the human leukocyte antigen (HLA) region, affecting the levels of all IgG subclasses. The most significant associations are observed between the G1m (f), G2m(n) and G3m(b*) allotypes, and IgG1, IgG2 and IgG3, respectively. Additionally, we describe selective associations with IgG4 at 16p11.2 (ITGAX) and 17q21.1 (IKZF3, ZPBP2, GSDMB, ORMDL3). Interestingly, the latter coincides with a highly pleiotropic signal where the allele associated with lower IgG4 levels protects against childhood asthma but predisposes to inflammatory bowel disease. Our results provide insight into the regulation of antibody-mediated immunity that can potentially be useful in the development of antibody based therapeutics. - Source: PubMed
Publication date: 2024/09/14
Olafsdottir Thorunn AThorleifsson GudmarLopez de Lapuente Portilla AitzkoaJonsson StefanStefansdottir LiljaNiroula AbhishekJonasdottir AslaugEggertsson Hannes PHalldorsson Gisli HThorlacius Gudny EArnthorsson Asgeir OBjornsdottir Unnur SAsselbergs Folkert WBentlage Arthur E HEyjolfsson Gudmundur IGudmundsdottir SteinunnGunnarsdottir KristbjorgHalldorsson Bjarni VHolm HilmaLudviksson Bjorn RMelsted PallNorddahl Gudmundur LOlafsson IsleifurSaevarsdottir SaedisSigurdardottir OlofSigurdsson AsgeirTemming RobinÖnundarson Pall TThorsteinsdottir UnnurVidarsson GesturSulem PatrickGudbjartsson Daniel FJonsdottir IngileifNilsson BjörnStefansson Kari - Genome-wide association studies have identified several risk alleles for early childhood asthma, particularly in the 17q21 locus and in the cadherin-related family member 3 (CDHR3) gene. Contribution of these alleles to the risk of acute respiratory tract infections (ARI) in early childhood is unclear. - Source: PubMed
Forsström VilleToivonen LauraHomil KiaraWaris MattiPedersen Casper-Emil TBønnelykke KlausJartti TuomasPeltola Ville - Serine proteases (PRSS) constitute nearly one-third of all proteases, and many of them have been identified to be testis-specific and play significant roles during sperm development and male reproduction. PRSS54 is one of the testis-specific PRSS in mouse and human but its physiological function remains largely unclear. In the present study, we demonstrate in detail that PRSS54 exists not only in testis but also in mature sperm, exhibiting a change in protein size from 50 kDa in testis to 42 kDa in sperm. Loss of PRSS54 in mice results in male subfertility, acrosome deformation, defective sperm-zona penetration, and phenotypes of male subfertility and acrosome deformation can be rescued by Prss54 transgene. Ultrastructure analyses by transmission electronic microscopy further reveal various morphological abnormalities of Prss54-/- spermatids during spermiogenesis, including unfused vacuoles in acrosome, detachment and eccentrical localization of the acrosomal granules, and asymmetrical elongation of the nucleus. Subcellular localization of PRSS54 display that it appears in the acrosomal granule at the early phase of acrosome biogenesis, then extends along the inner acrosomal membrane, and ultimately presents in the acrosome region of the mature sperm. PRSS54 interacts with acrosomal proteins ZPBP1, ZPBP2, ACRBP, and ZP3R, and loss of PRSS54 affects the distribution of these proteins in testis and sperm, although their protein levels are largely unaffected. Moreover, Prss54-/- sperm are more sensitive to acrosome reaction inducers. - Source: PubMed
Shen ChunlingXiong WenfengLi ChaojieGe HaoyangShen YanTang LingyunZhang HongxinLu ShunyuanFei JianWang Zhugang - Childhood wheeze represents a first symptom of asthma. Early identification of children at risk for wheeze related to 17q12-21 variants and their underlying immunological mechanisms remain unknown. We aimed to assess the influence of 17q12-21 variants and mRNA expression at birth on the development of wheeze. - Source: PubMed
Laubhahn KristinaBöck AndreasZeber KathrinUnterschemmann SandraKunze SonjaSchedel MichaelaSchaub Bianca