Ask about this productRelated genes to: LZTFL1 Blocking Peptide
- Gene:
- LZTFL1 NIH gene
- Name:
- leucine zipper transcription factor like 1
- Previous symbol:
- -
- Synonyms:
- BBS17
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2000-06-16
- Date modifiied:
- 2016-10-05
Related products to: LZTFL1 Blocking Peptide
Related articles to: LZTFL1 Blocking Peptide
- Sperm flagellar axoneme comprises microtubules (MT) and associated machinery and is an integral determinant of sperm motility. Reports from our lab show reduced levels of acetyl α-tubulin, and HDAC6, along with compromised axoneme polymerization in sperm of asthenozoospermic men. These observations prompted us to identify the sperm repertoire of HDAC6-interacting proteins(HIPs) associated with the MTs. HIPs and Microtubule associated protein (MAP) fractions, respectively, were isolated from sperm of normozoospermic individuals, subjected to tandem mass spectrometry(MS) using a bottom-up approach and proteins in the two groups were identified. 1224 and 315 proteins were identified in the respective groups. Seven clusters of HIPs were among the top 20 significant clusters. Proteins were manually curated from these relevant clusters and overlapped with the MAPs dataset which identified 14 HDAC6 interacting proteins to be associated with MTs (HMAPs). On further analysis with MAP analyzer-LZTFL1, RAB7A, AIFM1 demonstrated low specificity toward MT whereas MYH10 and CFAP53 demonstrated high specificity. Among these HMAPs, EEF1A2, MYH10, ANXA1, TUFM, SOD1, and SRSF7 are known to interact with HDAC6 as documented in the BioGRID database. Interaction of CFAP53 with HDAC6 was validated by double immunofluorescence staining and co-immunoprecipitation in rat sperm. LFQ-DDA analysis of these HMAPs, revealed significantly lower abundance of CFAP53 and TUFM with higher abundance of MYH10 in asthenozoospermic men. Their differential expression in men with poor sperm motility as well as enrichment of acetylation on these HMAPs highlights their association with HDAC6 in maintaining axonemal stability/dynamicity and acetylation-deacetylation to the extent required for sperm motility, although interpretation is limited by the small sample size, restricted availability of human sperm for experimental validation, and reliance on acetylation predictions. - Source: PubMed
Publication date: 2026/02/27
Chawan VeenaPatankar AniketYevate SmitaGajbhiye RahulKushte SinetraGanla KedarParte Priyanka - COVID-19 severity is influenced by a complex interplay between host, viral, and environmental factors. Emerging evidence suggests that Neanderthal-derived genetic variants may influence the progression and severity of SARS-CoV-2 infection. This study aimed to evaluate the association between selected Neanderthal-derived variants and COVID-19 severity in the population of the Republic of Srpska, considering relevant clinical, sociodemographic, and lifestyle factors. This multicentric cross-sectional study included 402 participants, classified as healthy or SARS-CoV-2-positive individuals. A total of 378 COVID-19-positive participants were further stratified according to disease severity and hospitalization status. All individuals were genotyped for the Neanderthal-derived rs1156361 (C/T) and rs35044562 (A/G) variants. Detailed sociodemographic, clinical, and lifestyle data were also collected. A higher frequency of the rs35044562 AG genotype was observed among hospitalized patients compared with non-hospitalized individuals (36.8% vs. 20.9%; = 0.005), while the AA genotype was more prevalent among non-hospitalized patients (77.3% vs. 63.2%, = 0.015). Multivariable logistic analysis showed that carriers of the AG genotype had a higher chance of hospitalization compared to AA carriers (adjusted OR = 1.372, 95% CI = 0.763-6.383, and = 0.021). Hospitalized patients more frequently carried the combined CT () and AG () genotypes, supporting a potential synergistic effect. Several sociodemographic factors, including age, sex, education, employment, and urban residence, were also associated with COVID-19 severity, while no significant associations were observed in allele-based analyses. gene polymorphisms may influence COVID-19 severity, with heterozygote-specific and combined risk effects observed. These preliminary findings are exploratory and require validation in larger cohorts, but may guide future studies and targeted interventions in high-risk groups. - Source: PubMed
Publication date: 2026/02/22
Dubravac Tanasković MilenaMijović BiljanaKulić JovanJoksimović BojanDrašković-Mališ KristinaMašić SrđanVladičić-Mašić JelenaKrsmanović LjiljanaRadulović DanijelaElez-Burnjaković Nikolina - Human chromosome 3p21.31 variants introgressed from Neanderthals have been associated with a higher risk of developing a severe form of COVID-19. These Neanderthal DNA variants would regulate the expression of several genes, including (implicated in the epithelial-mesenchymal transition) and proinflammatory chemokine receptors. - Source: PubMed
Publication date: 2025/11/12
Vázquez-Coto DanielGarcía-Clemente MartaHermida-Valverde TamaraAlbaiceta Guillermo MAmado LauraVega-Prado Lorena MGarcía-Lago ClaudiaHerrero-Puente PabloMartínez-Borra JesúsLorca RebecaGómez JuanCoto Eliecer - Interventions to prevent type 1 diabetes (T1D), an immune-mediated disease requiring lifelong treatment, remain limited. We sought to identify novel therapeutic targets for T1D through Mendelian randomization and colocalization using immune cell-derived instruments. - Source: PubMed
Publication date: 2025/11/26
Sklar JulieStacey DavidNickel GraceButterworth Adam SAllara EliasGaziano Liam - Over the past four years, pivotal discoveries have deepened the understanding of the relationship between genetic factors and SARS-CoV-2 infection. Numerous genes associated with severe COVID-19 suggest a potential genetic predisposition, which may help explain why some individuals develop more serious illnesses. Emerging evidence highlights the role of genes involved in pulmonary immunity, such as Forkhead box Protein P4 (FOXP4), whose increased expression in lung tissue has been linked to more severe disease. Other genes - Transmembrane Protease Serine-2 (TMPRSS2), Leucine Zipper Transcription Factor Like-1 (LZTFL1), Solute Carrier family 6 member 20 (SLC6A20), Tyrosine Kinase-2 (TYK2), Angiotensin-Converting Enzyme (ACE), and FYVE and Coiled-Coil Domain-Containing-1 (FYCO1) - have also been implicated in COVID-19 severity. In contrast, certain genetic variants - such as the T-allele of rs12329760 in the TMPRSS2 gene and rs35705950-T in the Mucin-5B (MUC5B) gene - may confer protection against severe disease. Overall, the evidence suggests that genetic factors can influence both susceptibility to and protection from severe COVID-19, although these associations are likely shaped by complex interactions with environmental, behavioral, and other biological factors. This review summarizes current knowledge on genetic determinants linked to COVID-19 outcomes. - Source: PubMed
Publication date: 2025/06/20
Beuren ThaisFerrari FilipeFranzoni Leandro TolfoGoulart Cássia da LuzVal FernandoCipriano GersonStein Ricardo