Ask about this productRelated genes to: UGDH Blocking Peptide
- Gene:
- UGDH NIH gene
- Name:
- UDP-glucose 6-dehydrogenase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 4p14
- Locus Type:
- gene with protein product
- Date approved:
- 1997-12-01
- Date modifiied:
- 2015-08-24
Related products to: UGDH Blocking Peptide
Related articles to: UGDH Blocking Peptide
- Frontotemporal dementia (FTD) is a genetically and clinically heterogeneous neurodegenerative disorder with no disease-modifying treatments. Plasma proteomic signatures offer a promising avenue for uncovering disease mechanisms and developing targeted interventions. - Source: PubMed
Publication date: 2026/07/25
Yao YuanZou QinChen Ke - Cannabidiol (CBD) exhibits broad anti-inflammatory and neuroprotective effects. Although CBD has been reported to act on multiple molecular targets, the direct protein interactors and molecular mechanisms underlying its complex pharmacological activities remain incompletely understood. In this study, we developed a biotinylated CBD probe (II-2) and a FITC-labeled CBD fluorescent probe (III-3) for affinity enrichment and cellular imaging, respectively. Probe-mediated target fishing identified UDP-glucose dehydrogenase (UGDH) as a potential CBD-interacting protein. Competitive pull-down and western blot analysis showed that the CBD-derived probe specifically enriched UGDH, and this enrichment was competitively attenuated by excess CBD. Biolayer interferometry was consistent with an apparent micromolar affinity association between CBD and UGDH under the assay conditions, with an apparent of approximately 5.8 μM. Functional assays showed that CBD enhanced UGDH enzymatic activity in a LPS-induced inflammatory model without markedly altering UGDH protein expression. Immunofluorescence imaging further supported the intracellular spatial association between the CBD-derived fluorescent probe and UGDH. These findings suggest that UGDH is a potential CBD-interacting protein and provide an experimental basis for further elucidating the molecular basis of CBD-related anti-inflammatory activity. - Source: PubMed
Publication date: 2026/06/23
Wang XiaoChu FengxinZhou ShiyuChen BoZou ShuxianFei QingshuRen RenSu MengxiangDi Bin - Awns are crucial spike traits in Poaceae plants and are closely associated with seed development. Griseb. is a high-quality alpine forage and an essential grass species for ecological restoration. To reveal the regulatory mechanism of awns on thousand seed weight in , 20 germplasm accessions were used as experimental materials in this study. Superior germplasms were screened via phenotypic correlation analysis. The screened superior germplasm was subjected to awned and de-awned treatments. Physiological indicators during seed development under the two treatments were measured at the milk stage, dough stage, and full ripe stage, and transcriptome sequencing was further used to identify the core regulatory pathways and key genes. The results showed that awn length was extremely significantly positively correlated with thousand seed weight ( < 0.01), and the optimal germplasm PI 655186 with superior awn length and thousand seed weight was obtained. Compared with the de-awned treatment, the awn-retained treatment significantly increased the contents of soluble sugar and starch in seeds from the milk stage to the dough stage and enhanced the activities of SOD, CAT, and POD to maintain redox homeostasis. Transcriptome analysis indicated that differentially expressed genes were significantly enriched in pathways including starch and sucrose metabolism and ascorbate and aldarate metabolism, among which , , , and were identified as key genes regulating seed development, and WGCNA showed that the brown module was significantly correlated with soluble sugars and starch, with hub genes consisting of seven 60S ribosomal proteins and one prolyl 4-hydroxylase. In conclusion, awns positively affect the thousand seed weight of seeds by promoting the synthesis of storage substances, optimizing the antioxidant enzyme system, and regulating the ascorbate and aldarate metabolism pathway and the expression of hub genes. These findings clarify the physiological and molecular mechanisms by which awns regulate seed thousand seed weight and provide a theoretical basis and gene resources for the innovation of high-yield and high-quality germplasms of alpine forage grasses. - Source: PubMed
Publication date: 2026/06/01
Qiu YongsenLu HuanhuanZhao YancuiTang LiubanZhang FeiZhang RuiXie Wengang - Melon (.) is a widely cultivated fruit globally, valued for its high nutritional content and diverse culinary uses. However, the molecular mechanisms underlying flavor enhancement mediated by grafting remain poorly understood. - Source: PubMed
Publication date: 2026/05/01
Zhang HaoMuhammad Mohsin KaleemLiang QiganDu YinkeMaerhaba PaerhatiTian BanlvZhang HaojieZhang WenweiHuang YuanWang MinZhu JingrongFu Xiaofa - Despite the widely reported experimental anti-tumor effects, metformin's role remains exceedingly complex, with contradictory results in clinical trials. Our study, based on metabolomics analysis of lung adenocarcinoma (LUAD) samples, xenografts, and cells, unveils a novel process that metformin promotes the conversion of UDP-glucose (UDPG) to UDP-glucuronic acid (UDPGA) in glucuronic acid metabolism. Mechanistically, metformin activates UDP-glucose 6-dehydrogenase (UGDH) through AMPK-mediated phosphorylation of UGDH(S476), a previously unstudied phosphorylation site, impeding the binding of UDP-Xyl to UGDH and the subsequent allosteric inhibition. Consequently, metformin-treated cells are more reliant on UXS1, a downstream metabolic enzyme of UGDH, for detoxifying UDPGA based on the "kitchen-sink" model. Through comprehensive virtual screening of a compound library, we identified that plantainoside is a potent UXS1-targeting agent. Remarkably, when combined with metformin, plantainoside exhibits a superior synergistic lethal effect in LUAD cells, organoids, xenografts, and spontaneous models. Moreover, this combination not only directly targets tumor cells but also synergistically boosts CD8+ T cells and suppresses the differentiation of macrophages, thereby significantly enhancing immunotherapy efficacy. Collectively, our results shed light on metformin's complicated role by revealing its novel impact on glucuronic acid metabolism and dependence on UXS1; thus, targeting UXS1 combined with metformin represents a highly promising new strategy. - Source: PubMed
Publication date: 2026/05/10
Sui QihaiChen ZhencongShan GuangyaoHu ZhengyangJin XingLiang JiaqiYi YanjunYin JiachengShi HaochunJiang XifeiXi JunjieLin ZongwuZhan ChengSun FenghaoJiang Wei