Ask about this productRelated genes to: AIFM1 Blocking Peptide
- Gene:
- AIFM1 NIH gene
- Name:
- apoptosis inducing factor mitochondria associated 1
- Previous symbol:
- PDCD8, NAMSD
- Synonyms:
- AIF, CMTX4
- Chromosome:
- Xq26.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-05-28
- Date modifiied:
- 2017-01-12
Related products to: AIFM1 Blocking Peptide
Related articles to: AIFM1 Blocking Peptide
- Mitochondrial dysfunction is a key pathological feature of vascular dementia (VaD), yet the specific systemic and localized proteins involved remain unclear. We aim to utilize Mendelian randomization (MR) of plasma proteomics and Gene Expression Omnibus (GEO) datasets to identify systemic circulating biomarkers associated with VaD risk, and subsequently use models to investigate whether these systemic signals correspond to actual neuropathological mitochondrial changes in the brain. - Source: PubMed
Publication date: 2026/07/09
Liu QianTan HuizhongTong KekeLuo RuhaiLi HanquanQiu FengWang ShiliangXie LeZhang XiuliWu Dahua - To observe the effect of electroacupuncture (EA) at "Hegu" (LI4) and "Quchi" (LI11) on skin inflammatory injury, itching, and poly(ADP-ribose) polymerase 1 (PARP1)-dependent cell death (Parthanatos) in mice with atopic dermatitis (AD) based on the protease-activated receptor 2 (PAR2)/transient receptor potential vanilloid 3 (TRPV3) pathway, and to explore the possible mechanism of EA in the treatment of AD. - Source: PubMed
Huang Liu-YangYang Shu-RuiTang QianLu Da-MinXue Ting-ZhengYang Wen-ZhuoHe Qian-LiLiang Feng-XiaChen Rui - The cochlear microphonic (CM) primarily reflects the composite receptor potential of outer hair cells (OHCs), providing an objective assessment of OHC mechanoelectrical transduction (MET) capacity. However, systematic studies on CM in basic research remain scarce, and baseline CM values for CBA/CaJ mice have not yet been established. Moreover, whether CM can functionally differentiate between auditory neuropathy (AN) and noise-induced hearing loss (NIHL) has not been systematically addressed. This study aimed to establish normative CM reference values for CBA/CaJ mice and to explore the utility of CM as an objective electrophysiological tool for assessing OHC function across different pathophysiological conditions. - Source: PubMed
Publication date: 2026/06/30
Chen YuhanLi JinChen ZiyiShi TaoWang Qiuju - PANoptosis, a form of programmed cell death involving crosstalk among pyroptosis, apoptosis, and necroptosis, has recently emerged as a key player in tumor progression and therapy resistance. Despite growing evidence linking PANoptosis to various cancers, the prognostic significance of PANoptosis-related genes (PANRGs) and their roles in breast cancer is not well defined. Investigating their relevance could reveal novel biomarkers for patient stratification and identify new therapeutic targets to overcome resistance to existing treatments. - Source: PubMed
Publication date: 2026/06/15
Hong JinghuiWei ZhihaoLi MengxinGao XiaochuanWu YuhengWang XuyutianWang XinZhang TianxingSong Dong - AIFM1 encodes the X-linked oxidoreductase 'apoptosis-inducing factor 1, mitochondrial' that mediates caspase-independent programmed cell death and is involved in redox metabolism. To date, cardiac involvement has been reported in four patients with AIFM1 variants, primarily presenting as ventricular hypertrophy, but its clinical course and prognosis remain not well understood. - Source: PubMed
Publication date: 2026/06/22
Sandmann ChristophGudapati SwathiMayr Johannes AJamra Rami AbouKovacevic AlexanderSyrbe Steffen