Ask about this productRelated genes to: UMPS Blocking Peptide
- Gene:
- UMPS NIH gene
- Name:
- uridine monophosphate synthetase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: UMPS Blocking Peptide
Related articles to: UMPS Blocking Peptide
- Adrenocortical cancer (ACC) is a rare endocrine malignancy with a variable prognosis. This study examines clinical outcomes of patients with ACC who underwent surgery in an endocrine surgery unit over 14 years. - Source: PubMed
Publication date: 2026/08/06
Kamalakkannan NTahir FO'Toole SAl-Mukhtar ANewell-Price JBalasubramanian S P - Laparoscopic ovariectomy (LOE) is a common procedure for elective sterilization in dogs and is associated with less tissue trauma than open techniques. However, manipulation of the ovarian pedicle may still induce nociceptive stimulation and contribute to perioperative inflammatory responses and changes in antioxidant enzyme activity. Topical administration of local anaesthetic to the ovarian pedicle may improve perioperative analgesia in minimally invasive surgery. - Source: PubMed
Çiplak Alper YasinPolat Bülent - : Hyperfunctioning thyroid nodules are generally considered to have a low malignancy risk, but data on genuine hyperfunctioning thyroid neoplasms remain limited. This study aimed to characterize the clinicopathologic features and diagnostic implications of true hyperfunctioning thyroid neoplasms through lesion-level imaging-pathologic correlation and to estimate their observed frequency within a surgically treated cohort. : We retrospectively reviewed 82 hyperthyroid patients at our institution with thyroid scintigraphy suggestive of solitary or multiple toxic nodules between 2014 and 2024; 25 underwent thyroidectomy. True hyperfunctioning thyroid neoplasms were defined by lesion-level imaging-pathologic correlation. : Among the 25 surgically treated patients, seven had confirmed hyperfunctioning carcinoma or tumors of uncertain malignant potential (UMP) (28.0%; 95% CI, 14.1-47.8%). When referenced against the full scintigraphic cohort of 82 patients, of whom only 30.5% underwent surgery, the observed rate was 8.5% (95% CI, 4.2-16.6%); however, this figure should be interpreted with caution given the inherent surgical selection bias. Four patients had overt carcinomas. The remaining three patients had UMPs. In nodule-based analysis, hyperfunctioning neoplasms were significantly larger than coexisting tumors (5.0 ± 2.8 vs. 0.8 ± 0.7 cm, = 0.007) and more often follicular-patterned (85.7% vs. 27.3%; RR, 3.14; 95% CI, 1.14 to 8.64; = 0.0498). : These findings indicate that hyperfunctioning status does not definitively exclude malignancy, while also emphasizing that the absolute malignancy frequency in unselected hyperthyroid populations remains uncertain. - Source: PubMed
Publication date: 2026/07/18
Huang Pang-JuiChi Shun-YuHuang Shun-ChenChang Yen-HsiangChou Chen-Kai - Cold tumors, defined by an immunosuppressive microenvironment and metabolic stress, including glutamine deficiency, frequently exhibit resistance to therapeutic interventions. This study examined the role of glutathione peroxidase 1 (GPX1) in mediating resistance to cuproptosis and ferroptosis during glutamine deprivation. Through integrated multi-omics analyses, CRISPR-mediated gene editing, and functional assays in cold tumor cell lines, we identified GPX1 as a key regulator of redox homeostasis and a protector against cuproptosis. Upstream, glutamine deprivation induced the SLC7A11 upregulation, which enhanced GPX1-mediated resistance through the maintenance of pyrimidine metabolism. Downstream, GPX1 knockout mediated cross-sensitization to ferroptosis by altering the Fenton reaction, thereby exacerbating cell death. In vivo experiments confirmed that GPX1 knockout restored sensitivity to cuproptosis inducers and improved the efficacy of PD-L1 blockade. Collectively, these findings position GPX1 as a central metabolic checkpoint in cold tumors and highlight the SLC7A11-UMPs-GPX1 axis as a promising therapeutic target for overcoming treatment resistance and enhancing immunotherapy response. - Source: PubMed
Publication date: 2026/07/02
Yang ShuangZhang ChengyeMei ZhusongYe QiaoGuo GuangjinZhu GuizhenZheng XiangyiCui YueyingGu WeijieZhou YanLiu GuoquanWang GuangyunYang Zhaoting - Monitoring food freshness is crucial for safety, driving demand for effective real-time detection. Recently, pH-responsive colorimetric sensors based on metal-organic frameworks (MOFs) are of great interest, though their performance needs improvement. Herein, a composite (UiO-66@MR) was prepared using UiO-66 as a porous carrier and methyl red (MR) as a colorimetric probe, showing excellent pH response across a broad range (pH 2.0-11.0). This composite was fixed onto paper to construct a UiO-66@MR paper-based sensor (UMPS). Using the spoilage markers ammonia (NH), dimethylamine (DMA), and trimethylamine (TMA) as representative volatile organic compounds (VOCs), UMPS demonstrated high sensitivity, a wide detection range, and good selectivity due to UiO-66's high surface area and MR's color-changing properties. The UMPS showed linear responses toward NH, DMA, and TMA over the ranges of 1-1000, 1-100, and 5-1000 ppb, with detection limits of 0.724, 0.443, and 0.971 ppb, respectively. In tests on shrimp and beef, UMPS showed clear color changes, and the color difference (ΔE) strongly correlated with total volatile basic nitrogen (TVB-N) content over time (R = 0.9699 and 0.9646). The sensor also exhibited excellent reproducibility, reusability, and stability. Hierarchical cluster analysis (HCA) and principal component analysis (PCA) confirmed its effectiveness for real-time freshness assessment. Thus, UMPS offers a high-performance, convenient visual platform for monitoring food freshness. - Source: PubMed
Publication date: 2026/07/01
Kong YijieFeng XinyuSun WeichengBi YanmingSong ChengzeLiu Sha