CKMM Blocking Peptide
- Known as:
- CKMM Blocking Peptide
- Catalog number:
- 33r-9549
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- CKMM Blocking Peptide
Related genes to: CKMM Blocking Peptide
- Gene:
- CKM NIH gene
- Name:
- creatine kinase, M-type
- Previous symbol:
- CKMM
- Synonyms:
- -
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-02-10
Related products to: CKMM Blocking Peptide
Related articles to: CKMM Blocking Peptide
- IntroductionCardiovascular-kidney-metabolic (CKM) syndrome is characterized by chronic inflammation that may drive heart failure. Peritoneal dialysis (PD), while lifesaving, may induce local and systemic inflammation through bioincompatible intraperitoneal solutions, potentially amplifying CKM syndrome. We investigated peritoneal mononuclear phagocyte phenotypes, key-drivers of inflammation, and whether these correlate with systemic inflammation and cardiac function in PD-treated patients.MethodsWe collected patient-matched peripheral blood-derived and PD-effluent (PDE)-derived cells from 13 adult PD-treated patients and characterized peritoneal immune populations by unbiased clustering using a mononuclear phagocyte-selective flow cytometry panel. In a subsequent cohort of 21 PD-treated patients, we correlated cardiac function [left ventricular global longitudinal strain (LV-GLS)] with peritoneal immune profiles and serum inflammatory markers.ResultsMononuclear phagocytes predominated in PDE and exhibited a more differentiated phenotype than blood-derived mononuclear phagocytes. Unbiased clustering revealed substantial overlap between blood- and PDE-derived classical monocytes. A higher PDE-derived differentiated monocyte-to-dendritic cell ratio was related to more impaired LV-GLS. Peritoneal monocytes showed reduced antigen-presenting capacity in patients with impaired cardiac function, potentially influenced by diabetes mellitus. Systemic inflammatory markers were largely undetectable in this stable PD-cohort.ConclusionOur findings suggest a link between peritoneal immune characteristics and cardiac dysfunction, characterized by a shift towards a higher monocyte-to-dendritic cell ratio in PD-treated patients with more pronounced cardiac dysfunction. The directionality and mechanisms underlying this association remain to be established and given the limited patient number and cross-sectional design, these findings should be considered as hypothesis-generating. The applied flow cytometry and unsupervised clustering approach offers a promising and scalable tool for future in-depth investigation of the peritoneal immune microenvironment and its relation to PD-related clinical outcomes, including CKM sequelae. - Source: PubMed
Publication date: 2026/08/14
Karsten MickyHahn NicoVree PuckDavies Luke CVervloet Marc GVan Den Bossche JanJakulj Lily - Recently, the American Heart Association defined, staged, and highlighted the multisystem consequences of poor cardiovascular-kidney-metabolic (CKM) syndrome health with a clarion call to harmonize guidelines and provide opportunities for actionable preventive interventions before overt CVD. In the United States, the components that comprise CKM (obesity, diabetes, hypertension, etc.) are potent risk factors for poor maternal and neonatal outcomes, with a disproportionate burden among racial/ethnic minorities. However, population-level data on CKM syndrome in reproductive-aged women are scarce, but a critical prerequisite in evaluating the impact of CKM stages on overall pregnancy outcomes. - Source: PubMed
Publication date: 2026/02/17
Broni Eric KAryee Ebenezer KLachaud AmberPeprah AmponsahLewey JenniferLevine Lisa D - To evaluate the role of finerenone, a nonsteroidal mineralocorticoid receptor antagonist (MRA), in heart failure with preserved or mildly reduced ejection fraction (HFpEF/HFmrEF). - Source: PubMed
Publication date: 2026/08/13
Khidhir AngelaKalra Dinesh K - Cardiovascular-kidney-metabolic (CKM) syndrome represents an emerging systemic disorder characterized by intertwined metabolic dysfunction, chronic kidney disease, and cardiovascular injury, yet robust preclinical models and mechanistic insights remain limited. - Source: PubMed
Publication date: 2026/07/29
Ye Hai-LunWang Ya-NiLi Gang-AoJin Xing-HuiLi YangJin Ying-Hua - Cardiovascular-kidney-metabolic (CKM) syndrome, characterized by disturbances in glucose and lipid metabolism as its core pathophysiological feature, is a major driver of target organ damage. While early risk stratification in CKM stages 0-3 is critical to intercept renal decline, the practical utility of accessible metabolic surrogates remains poorly characterized. This study evaluated and compared the prospective capacity of the atherogenic index of plasma (AIP), triglyceride-glucose (TyG) index, and C-reactive protein-triglyceride glucose index (CTI) for predicting renal deterioration in early-stage CKM. Data were extracted from the China Health and Retirement Longitudinal Study (2011-2015). In total, 4064 participants aged ≥ 45 with CKM stages 0-3 (with exclusion of participants with baseline CKM stage 4) were prospectively followed. Renal function decline was defined as an estimated glomerular filtration rate (eGFR) decrease of ≥30% over 4 years, calculated using the CKD-EPI 2012 cystatin C equation. Multivariable logistic regression, restricted cubic splines (RCSs), and receiver operating characteristic (ROC) curves were applied. Overall, 122 participants developed the renal outcome. In fully adjusted models, AIP, TyG, and CTI were valid independent risk factors for renal decline, with the lipid-driven AIP exhibiting the strongest association (OR = 5.54, 95% CI: 3.30-9.29; TyG: OR = 1.97, 95% CI: 1.49-2.59; CTI: OR = 1.63, 95% CI: 1.30-2.05; all < 0.001). RCS analysis demonstrated significant non-linear dose-response trajectories, with renal risk escalating sharply past specific exploratory inflection points (AIP = 0.97, TyG = 7.80, CTI = 8.07). ROC curves confirmed robust predictive performance (AUCs > 0.75), with AIP performing optimally (AUC = 0.773). AIP, TyG, and CTI are independent longitudinal predictors of renal decline in early-stage CKM, with AIP demonstrating superior discriminatory power. Monitoring these composite indices and maintaining them within observed metabolic ranges may aid in early renal risk stratification and monitoring, though the exploratory statistical inflection points identified require validation in independent cohorts before clinical application. - Source: PubMed
Publication date: 2026/08/04
Yan ShixinLiu Haiyang