Ask about this productRelated genes to: Vps45 Blocking Peptide
- Gene:
- VPS45 NIH gene
- Name:
- vacuolar protein sorting 45 homolog
- Previous symbol:
- VPS45B, VPS45A
- Synonyms:
- h-vps45, H1
- Chromosome:
- 1q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-02-08
- Date modifiied:
- 2019-04-23
Related products to: Vps45 Blocking Peptide
Related articles to: Vps45 Blocking Peptide
- Triple-negative breast cancer (TNBC) is an aggressive subtype lacking estrogen and progesterone receptors and HER2 amplification. Representing 10-15% of breast cancer cases, TNBC disproportionately affects Black and pre-menopausal women and is associated with poorer outcomes. With chemotherapy as the primary systemic treatment option, achieving a pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) is a key prognostic factor. However, TNBC biological heterogeneity complicates treatment response prediction. This study aimed to identify transcriptomic biomarkers predictive of NAC response in TNBC patients and evaluate machine-learning models for response classification. - Source: PubMed
Publication date: 2026/03/26
Amniouel SoukainaJafri Mohsin Saleet - This study aimed to screen the specific modules and hub genes of hyperlipidemia. - Source: PubMed
Publication date: 2025/12/10
Zhao ZhiyiCao YinGu AnnaYao Hanxin - Non-coding RNAs (ncRNAs) play crucial roles in the regulation of gene expression, but their genetic underpinnings and roles in human traits and diseases remain largely elusive. Here, we identified 38,441 long non-coding RNAs (lncRNAs) and 23,548 circular RNAs (circRNAs) from RNA sequencing (RNA-seq) data of 2,865 human cortex samples, of which 27,453 lncRNAs and all circRNAs were not reported in GENCODE. Expression quantitative trait locus (eQTL) analyses identified cis-eQTLs for 15,362 lncRNAs and 1,312 circRNAs. We showed that lncRNA- or circRNA-eQTLs were largely independent of, and had larger effects on average than, eQTLs of their adjacent or parental protein-coding genes (PCGs). The circRNA-eQTLs were highly enriched in canonical splice sites, highlighting the crucial role of back-splicing in circRNA biogenesis. LncRNA-eQTLs were enriched for heritability of brain-related complex traits and associated with 72 (11.2%) of the colocalized genome-wide association study (GWAS) signals that showed no evidence of colocalization with PCG-eQTLs or splicing quantitative trait loci (QTLs) identified in the same dataset. We showcased lncRNAs (e.g., those near VPS45, MAPT, and RGS6) and circRNAs (e.g., that for GRIN2A) that may be implicated in complex traits through genetic regulation of ncRNAs. Our study provides insights into the genetic regulation of ncRNAs and their implications in brain-related complex traits. - Source: PubMed
Publication date: 2025/12/16
Chen LiGuo YazhouHou JunrenYang WenQi TingYang Jian - Rhizoctonia solani anastomosis group (AG)-5 is the predominant pathogen inciting maize banded leaf and sheath blight in Shanxi province, China, for which the sensitivity baseline to thifluzamide has been established. However, no risk assessment of thifluzamide resistance in R. solani AG-5 has been conducted. Consequently, thifluzamide-resistant mutants of R. solani AG-5 were generated by combined UV irradiation and fungicide selection in the laboratory. Fitness, genetic stability, intracellular structures, and fitness-related differentially expressed genes were subsequently analyzed. Ten resistant mutants were obtained, all of which exhibited moderate-to-high resistance that remained stable for 20 generations. These mutants showed a subtle expansion in their optimal growth temperature and pH ranges as their resistance to thifluzamide increased. Despite this, they exhibited reduced mycelial growth, sclerotia production, melanin formation, and virulence, whereas sclerotia germination rates were higher than in the parental sensitive strain. The mutant Y94.4R maintained vacuole numbers and size post-thifluzamide treatment, whereas the sensitive strain Y94 exhibited vacuole disappearance. Compared to Y94 strain, the expression levels of Atg22, Vps45, Ktr1_3, Aha1, DnaJ, Hikeshi, and Stip1 gene were less upregulated (1.81-3.65 folds) in Y94.4R strain under thifluzamide stress. No amino-acid substitutions were detected in SdhA, SdhB, and SdhD subunits; however, alanine (A) at position 46 of SdhC subunit was replaced by threonine (T) in thifuzamide-resistant mutants. This study showed that the resistant mutants exhibited reduced ecological fitness and competitiveness, suggested that the observed fitness costs might partially support the durability of thifluzamide under field conditions, and provided candidate genes for future disease-management strategies. - Source: PubMed
Publication date: 2025/09/09
Shi XiaojingLi YutingYang NaiboFu ShuhuiXin YanhuaZhang He - The plant hormone auxin is directionally transported in plant tissues by the actions of the auxin transport proteins. PIN-FORMED (PIN) family proteins asymmetrically localize at the plasma membrane, and facilitate auxin efflux, thereby promoting cell-to-cell polar auxin transport. In previous studies, we have identified the trans-Golgi network-localized ARF GEF BEN1 (BIG5) and the Sec1/Munc18 protein BEN2 (VPS45) as membrane-trafficking components involved in PIN protein localization and auxin-dependent development. Here, we address the role of VPS45-interacting SYP4 Qa-SNARE proteins and the genetic relationship between VPS45 and SYP4 proteins. We show that ben2 and syp4 mutations affect the subcellular localization of SYP4 proteins and VPS45, respectively. Genetic interference of SYP42 and SYP43 genes results in PIN-trafficking defects and developmental alterations, such as decreased root meristem size and cotyledon venation defects, which are qualitatively reminiscent of those of ben2 and/or ben1; ben2 mutants. In addition, the ben2 mutation, which is assumed to compromise VPS45 activity, strongly enhances the developmental defects of the syp4 mutants. These results suggest that VPS45 and SYP4 Qa-SNARE proteins jointly play an important role in auxin-dependent plant development. - Source: PubMed
Publication date: 2025/11/13
Ogita KosukeFukasawa NarumiWang RuianFujisaki TsubasaKatagiri KaoriUemura TomohiroTanaka Hirokazu