Ask about this productRelated genes to: STX4 Blocking Peptide
- Gene:
- STX4 NIH gene
- Name:
- syntaxin 4
- Previous symbol:
- STX4A
- Synonyms:
- p35-2
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-23
- Date modifiied:
- 2014-11-18
Related products to: STX4 Blocking Peptide
Related articles to: STX4 Blocking Peptide
- Syntaxin-4 (Stx4), a member of the Qa-SNARE protein family, is a pivotal regulator of membrane trafficking. Stx4 is predominantly localized at the postsynaptic membrane of neurons and in glial cells, where it is essential for synaptic plasticity and the maintenance of neuronal homeostasis. Stx4 facilitates the activity-dependent exocytosis of glutamatergic receptors, thereby governing the balance between Long-Term Potentiation (LTP) and Long-Term Depression (LTD). Emerging evidence suggests that dysregulation of Stx4 is intricately linked to the pathogenesis of neurodegenerative diseases. In Alzheimer's disease, Stx4 is involved in synaptic dysfunction and cognitive impairment through its interactions with amyloid-β (Aβ) and tau pathologies, affecting receptor recruitment at dendritic spines. In Parkinson's Disease (PD), Stx4 contributes to α-synuclein proteostasis, dopaminergic signaling, neuroinflammation, and the maintenance of blood-brain barrier integrity. While its presence in cerebrospinal fluid highlights its potential as a candidate biomarker for these diseases, further validation is required to establish clinical utility. This review summarizes current mechanistic insights into Stx4's multifaceted roles in the neurodegenerative disorders and explores the therapeutic prospects of targeting Stx4-mediated pathways due to its translational potential. - Source: PubMed
Publication date: 2026/07/08
Li YueWei YunSongZhao JingBoQuan PuShengWang ChengJiang Mingfang - Bovine tuberculosis (bTB), caused by (), remains an ongoing global issue for human and animal health. The Bacille Calmette Guerin (BCG) vaccine offers immunity against bTB, however, the mechanisms underlying the heterogenous protective response, including variations across species and age groups requires further investigation. In this study, we focused on dendritic cells (DCs), which are crucial for adaptive immune stimulation following BCG vaccination. By capturing afferent lymph DCs (ALDCs) migrating from the skin, we investigated shifts in DC profiles and potential subset-specific functions in response to BCG vaccination. Single-cell RNA sequencing (scRNA-seq) was performed on samples from calves (n=3) before and after BCG vaccination, capturing the transcriptome of 20,761 individual cells expressing on average 3,036 genes, which were clustered into ALDCs, monocytes, T-cells, B-cells and NK cells. The ALDC subsets were further identified as cDC1 and cDC2. In homeostasis, ALDCs expressing potential subset-specific genes for cDC1, including ENSBTAG00000056208, , , , , and cDC2; , , , , and were identified. Following BCG vaccination, while both DC subsets exhibited gene expression signatures indicative of antigen-presenting function, migration, and DC maturation, cDC1 showed upregulation of genes consistent with metabolic alterations and lymphocyte recruitment, whereas cDC2 upregulated genes consistent with inflammatory responses. Overall, this study comprehensively describes the transcriptomic landscape of bovine ALDC subsets, providing evidence for the importance of subset-specific genes to BCG vaccination responses, while advancing knowledge on how ALDCs contribute to protective immunity against bTB. - Source: PubMed
Publication date: 2026/04/07
Sukmak RachrapeeMathie Heather ATaylor Richard SSun JianxuanShih BarbaraBell Charlotte RGray MarkMacqueen Daniel JHope Jayne C - Type 1 diabetes (T1D) is characterized by progressive loss of pancreatic b-cell function, which is accelerated by cytokine-induced senescence and the accompanying senescence-associated secretory phenotype (SASP). We investigated whether Syntaxin 4 (STX4), a t-SNARE protein previously recognized for its cytoprotective properties, can mitigate b-cell senescence under diabetogenic stress. - Source: PubMed
Publication date: 2026/03/09
Ahn MiwonOh EunjinVarghese Sneha SMcCown Erika MBhattacharya SupriyoDabrowska KatarzynaLovell Brooke LHansen NathanielPirrotte PatrickThurmond Debbie CDhawan Sangeeta - Dysregulation of the peripheral immune system may increase Alzheimer's disease (AD) risk, but the underlying cell type-specific mechanisms remain unclear. - Source: PubMed
Lindbohm Joni VStražar MartinLee Hang-MaoAshenberg OrrMars NinaSipilä Pyry NRipatti SamuliGraham DanKivimäki MikaXavier Ramnik J - Psoriasis (PsO) demonstrates frequent co-occurrence with metabolic syndrome (MetS). Nevertheless, the shared genetic architecture underlying both pathological conditions remains incompletely characterized. This investigation sought to examine genetic correlations between PsO and multiple MetS-associated traits, and to identify shared genetic risk loci and genes contributing to their coexistence. - Source: PubMed
Publication date: 2026/03/14
Jiang XinZhou PingZhang QiWang WanChunWang Dan