Ask about this productRelated genes to: SPOCK3 Blocking Peptide
- Gene:
- SPOCK3 NIH gene
- Name:
- SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
- Previous symbol:
- -
- Synonyms:
- testican-3
- Chromosome:
- 4q32.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-24
- Date modifiied:
- 2018-02-23
Related products to: SPOCK3 Blocking Peptide
Related articles to: SPOCK3 Blocking Peptide
- BACKGROUND/OBJECTIVES: OnabotulinumtoxinA (BoNT-A) use is an established preventive treatment for chronic migraine (CM); however, individual response rates vary. Although genetic factors may contribute to this variability, the underlying genetic determinants remain largely undefined, especially in Asian populations. Therefore, we aimed to identify genetic variants associated with the response to BoNT-A treatment in Han Chinese patients with CM. METHODS: We conducted a genome-wide quantitative trait locus (QTL) analysis using the Taiwan Precision Medicine (TPM) array in Han Chinese patients with CM receiving BoNT-A treatment according to the PREEMPT protocol. Treatment efficacy was assessed by calculating the improvement in monthly headache days after 24 weeks compared with baseline. Genotype–phenotype associations were assessed using a linear regression model adjusted for relevant clinical covariates. Functional annotation, Gene Ontology (GO) annotation, and linkage disequilibrium (LD) mapping were performed to interpret the biological importance of significant variants. RESULTS: We identified four intronic single nucleotide polymorphisms (SNPs) that showed genome-wide significance: rs11147666 in TRPC4, rs3924647 in LINC02197, rs56381512 in GTF2H2, and rs13126813 in SPOCK3. rs11147666 in TRPC4 showed the strongest association with treatment response. Patients with heterozygous variants showed lower improvement rates than those with common homozygotes. The implicated genes function in calcium ion transport, transcriptional regulation, and extracellular matrix interactions. Given the modest sample size and low minor allele frequencies, these findings should be interpreted as exploratory signals. CONCLUSION: This pilot genome-wide association study identified genetic variants linked to variability in BoNT-A response among Han Chinese patients with chronic migraine, highlighting potential candidate loci for future validation. Given the limited sample size and absence of an independent replication cohort, the reported loci should be interpreted as exploratory and hypothesis-generating findings. - Source: PubMed
Publication date: 2026/04/15
An Yu-ChinLiang Chih-SungTsai Chia-KuangTsai Chia-LinLin Yu-KaiLiao Wen-IYeh Po-KuanLin Guan-YuHsieh Cheng-HaoHung Kuo-ShengYang Fu-Chi - Endothelial cells (ECs) are key structural and functional components of the blood-brain barrier (BBB). Mouse models are frequently used to study EC biology within the BBB, yet the extent to which human and mouse BBB ECs share conserved transcriptomic features remains unclear. Here, we systematically compare transcriptomic profiles of BBB capillary ECs from adult mice and humans. - Source: PubMed
Publication date: 2026/03/12
Miao YuyangWang JianhaoLi WeihanMäe Maarja AndaloussiJeansson MarieMuhl LarsHe Liqun - Isolated REM sleep behavior disorder (iRBD) is among the strongest clinical markers of prodromal α-synucleinopathies. Pinpointing causal proteins may open the door to early diagnosis and disease-modifying therapies. - Source: PubMed
Publication date: 2026/01/07
Ye HongLiu ZhenzhenHuang YajingXu NaJiang ChaoyaXu QiuhanZhou Xuxia - Basement membrane-related genes (BMRGs) play a crucial function in the progression of various malignancies. This study aimed to explore the relationship between BMRGs and colon cancer. - Source: PubMed
Publication date: 2025/11/19
Wei JiajieWang HouZeChai JianGuo CeGong TianYiWang HengLi XiaoLongWu HaiFengXing BaoJianZhang YaJuanZhang HuiQingGuo Xing - Ovarian cancer (OC), a deadliest gynecological malignancy, lacks reliable predictive biomarkers for its heterogeneous clinical outcomes. Per- and polyfluoroalkyl substances (PFAS) are persisting endocrine disruptors potentially affecting female reproductive health, but their roles in OC remain unclear. We aimed to investigate the possible associations between PFAS and OC prognosis. - Source: PubMed
Publication date: 2025/09/12
Xie HongyuWang DanyunFeng LiangWang HuiLi Xiao