Ask about this productRelated genes to: MRGPRX2 Blocking Peptide
- Gene:
- MRGPRX2 NIH gene
- Name:
- MAS related GPR family member X2
- Previous symbol:
- -
- Synonyms:
- MRGX2
- Chromosome:
- 11p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-09
- Date modifiied:
- 2015-11-23
Related products to: MRGPRX2 Blocking Peptide
Related articles to: MRGPRX2 Blocking Peptide
- - Source: PubMed
Suzuki YasuyukiLiu ShuangMogi Masaki - Migraine is a complex neurologic disorder with a significant global burden. Mast cells, a type of immune cell residing in the meninges and in close contact with dural afferent neurons, have been proposed to play an important role in the pathophysiology of migraine. While mast cells have been studied in the context of migraine for decades, more recent work has begun to investigate how the mast cell-specific receptor Mas-related G protein-coupled receptor X2/B2 (MRGPRX2/B2) may be an important contributor to neuroimmune interactions in migraine. Neuropeptides released from meningeal sensory neurons such as substance P and pituitary adenylate cyclase-activating polypeptide (PACAP), can induce mast cell degranulation via MRGPRX2/B2, leading to neurogenic inflammation and peripheral neuronal sensitization. In this review, we discuss recent findings on how MRGPRX2/B2 may contribute to mast cell and sensory neuron interactions in the meninges and could serve as a novel target for new migraine therapeutics. - Source: PubMed
Nematgorgani ShivaBrandon Jane MDussor Gregory - The impact of psychological stress on vitiligo progression remains poorly understood. - Source: PubMed
Publication date: 2026/05/12
Geng Meng-MengZhang Shi-JiaoLi Xiao-HuiZhou YouLuo Long-FeiJiang ShanLei Tie-Chi - Recent evidence indicates that the Mas-related G protein-coupled receptor X2 (MRGPRX2) can be activated by several drugs, including neuromuscular blocking agents, fluoroquinolones, and vancomycin. However, the contribution of this mechanism to drug hypersensitivity reactions (DHRs) observed in clinical practice remains incompletely understood. Single-nucleotide polymorphisms (SNPs) in the gene may alter receptor reactivity and thereby influence drug tolerance. In this study, we investigated whether selected SNPs-previously described in patients with DHRs (N62S, S313R), known but not previously tested with drugs (S325L, E164R), and predicted (W248L)-affect responses to representative drug ligands. - Source: PubMed
Dziadowiec AlicjaKwitniewski MateuszRybka HubertSinkevich IvanPorebski Grzegorz - - Source: PubMed
Publication date: 2026/05/26
Ding NiLin Zhen-Jia