Ask about this productRelated genes to: MRGPRX2 Blocking Peptide
- Gene:
- MRGPRX2 NIH gene
- Name:
- MAS related GPR family member X2
- Previous symbol:
- -
- Synonyms:
- MRGX2
- Chromosome:
- 11p15.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-09
- Date modifiied:
- 2015-11-23
Related products to: MRGPRX2 Blocking Peptide
Related articles to: MRGPRX2 Blocking Peptide
- The understanding of anaphylaxis has evolved over time beyond the classical IgE-mediated paradigm. This review examines the role of Mas-related G protein-coupled receptor X2 (MRGPRX2) in non-IgE-mediated mast cell activation, a mechanism increasingly recognized in mast cell activation, anaphylaxis, and other mast cell-driven conditions. - Source: PubMed
Publication date: 2026/08/06
Zurlo MarcoLevi-Schaffer Francesca - Anaphylaxis attributable to non-immunoglobulin E (IgE)-mediated mechanisms represents an increasingly recognized and clinically challenging subset of severe hypersensitivity reactions. This review synthesizes recent advances in the understanding of IgE-independent pathways, with emphasis on literature published in the last 18 months, and highlights their implications for precision diagnostics and therapeutic targeting. - Source: PubMed
Publication date: 2026/07/28
Cardona VictoriaSala-Cunill Anna - Anaphylaxis during pregnancy is uncommon but remains one of the most critical emergencies in obstetric medicine because maternal deterioration and fetal hypoxia evolve simultaneously. Despite established treatment recommendations, diagnostic uncertainty and persistent concerns regarding epinephrine use continue to contribute to jeopardize preventable morbidity/mortality. This review examines recent advances in the recognition, management, and prevention of pregnancy-associated anaphylaxis, with emphasis on emerging concepts that may improve maternal-fetal safety. - Source: PubMed
Publication date: 2026/07/28
Tanno Luciana KaseDemoly Pascal - Allergic contact dermatitis (ACD) is a common and debilitating disease with a lifetime prevalence of 20%. Recently, the mast cell Mas-related G protein-coupled receptor B2 (MrgprB2) has been implicated in the pathogenesis of pruritus in ACD. Huanglian Ointment (HLO) demonstrates significant clinical efficacy in promoting skin healing, treating eczema, and alleviating skin inflammation and itching. However, the mechanism underlying the antipruritic effects of HLO has not yet been elucidated. - Source: PubMed
Publication date: 2026/07/22
Huang YunShen Zhou-YangSun XinMa Wen-YaWang Rui-QiXie Xiao-YaoWang Chang-MingChan-Zhu Yan-Yang Chen Fei-YanJiang Yu-CuiTang Zong-Xiang - Biosensors inspired by biological sensory systems are valuable tools for detecting physiological and environmental stimuli with high degrees of specificity and sensitivity. An itch irritant biosensor to detect environmental changes or pruritogenic substances in human blood or tissues highly associated with inflammation and prevalent conditions like atopic dermatitis (AD) has not been developed. To address this gap, we developed a novel bioelectronic sensor by integrating the human itch receptor Mas-related G-protein-coupled receptor X2 (MRGPRX2) with a graphene field-effect transistor (GFET). This MRGPRX2-GFET biosensor covalently immobilizes functional receptors, enabling direct conversion of ligand-binding events into quantifiable electrical signals. We demonstrate that the sensor can detect known MRGPRX2 agonists with exceptional sensitivity and specificity, achieving a detection limit for SP at approximately 7 pM. Molecular dynamics (MD) simulations and mutational effects reveal that ligand binding induces cytoplasmic conformational rearrangements in MRGPRX2, strengthening receptor-graphene coupling and providing a mechanistic basis for signal transduction. Importantly, the biosensor effectively distinguishes plasma samples from AD patients and healthy controls by capturing different electrical signal responses. In our study, we establish a versatile platform for diagnosing and subtyping chronic itch disorders and offer a generalizable strategy for developing membrane receptor-based multiplexed "itch-print" biosensors. - Source: PubMed
Publication date: 2026/07/23
Guo LuluZhang WeifengLi XuanNiu CanyangLiu ZiliZhang ZaiyuFan HonghaoGao XiheWang KaiyuLiu HaoranZhang ChunhongLi YingWang ZiranYang FanLi GuoqiangSun Jinpeng