Ask about this productRelated genes to: ApoBEC2 Blocking Peptide
- Gene:
- APOBEC2 NIH gene
- Name:
- apolipoprotein B mRNA editing enzyme catalytic subunit 2
- Previous symbol:
- -
- Synonyms:
- ARCD1, ARP1
- Chromosome:
- 6p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-08-12
- Date modifiied:
- 2016-10-05
Related products to: ApoBEC2 Blocking Peptide
Related articles to: ApoBEC2 Blocking Peptide
- - Source: PubMed
Publication date: 2026/07/13
Golzari-Sorkheh MahdiehZúñiga-Pflücker Juan Carlos - APOBEC2 is a well-conserved member of the AID/APOBEC family of cytidine deaminases. Most members of the family catalyze the conversion of cytosine to uracil either in DNA or RNA, thereby acting as DNA mutators and/or RNA editors. APOBEC2 is the only family member that appears to be catalytically inactive. Instead, its ability to bind, but not deaminate DNA, has been co-opted into a transcription-factor-like functionality. APOBEC2 is highly expressed in skeletal muscle, where it functions to promote and maintain muscle identity by suppressing nonmuscle genes. APOBEC2 is also expressed in several cell types within the hematopoietic lineage. Here, we show that loss of APOBEC2 disrupts proper lymphoid lineage differentiation, resulting in the emergence of lymphoid cells expressing both TCRs and BCRs, as well as additional markers that define a mixed T and B cell identity in both mice with a depletion in gene and humans with mutations in it. We further show that these T/B cells present dual functionality. Finally, we elucidate the molecular mechanisms associated with APOBEC2 deficiency that led to disruption of cell fate determination. Overall, our results establish APOBEC2 as a terminal repressor of B cell fates within the T cell lineage, whose loss results in disease outcomes in mice and humans. - Source: PubMed
Publication date: 2026/06/05
Moris Amro EliasGkougkousis ChristosSeebass Joachim GuidoTellioglu IremBakr AliLorenzo Jose PauloAbolhassani HassanAltenhofen JanBerntson LillemorRuf SandraHammarström LennartPan-Hammarström QiangImbusch Charles DPapavasiliou F Nina - Genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms (SNPs) at the 6p21.1 locus associated with gastric cancer (GC) risk. However, the underlying biological mechanisms remain poorly understood. - Source: PubMed
Publication date: 2026/05/12
Zheng ZhonghuaLi QianGu YuanliangGao XinxiangWang XinyaZhang YanAn FangmeiZhan QiangYin ShuangshuangGao YunPeng RuiLiu LiZhang ErbaoZhu MengChen XiaofengLi GangXu HaoJin GuangfuYan Caiwang - To study a non-redundant role of Tcf12 in retinal health. - Source: PubMed
Yu TianUlker-Yilmazer GizemKirman Dogan CanTurpin Emily RYuksel SeherHe Yu-GuangLudwig SaraKumar AshwaniXing ChaoEvers BretMoresco Eva Marie YBeutler Bruce AAredo BogaleUfret-Vincenty Rafael L - AllergoOncology has emerged as an interdisciplinary field exploring the interaction between allergic diseases and cancer; however, the lack of stable in vivo models has limited mechanistic investigations. This study aimed to establish an experimental animal model to explore the impact of systemic allergic responses on tumor progression and to provide preliminary insights into the regulatory role of allergy in cancer development. - Source: PubMed
Publication date: 2026/04/08
Fan XiaoyuGuo ShushuZhang WenchaoXu ZeaoSun SimanLi YanHe JiumingJin Hongtao