Ask about this productRelated genes to: CCT6B Blocking Peptide
- Gene:
- CCT6B NIH gene
- Name:
- chaperonin containing TCP1 subunit 6B
- Previous symbol:
- -
- Synonyms:
- Cctz2, TSA303
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-26
- Date modifiied:
- 2016-01-06
Related products to: CCT6B Blocking Peptide
Related articles to: CCT6B Blocking Peptide
- Chaperonins are crucial regulators of tumor biology by controlling the stability and function of oncogenic and tumor-suppressor proteins, influencing various tumorigenic signaling pathways. Although chaperonins have been widely discussed in various cancers, including hepatocellular carcinoma (HCC), the complex mechanisms by which they contribute to HCC progression remain insufficiently explored and require further investigation. - Source: PubMed
Publication date: 2025/11/26
Wang Shou-HuaLv Feng-YaLiu Yuan-JieLi Jie-PinHao Jia-QiWang Hong-Hua - To investigate the mechanism of ultra-high dose rate pulsed radiation in radiation-induced lung injury (RILI), providing an experimental and theoretical basis for the application of FLASH-RT (FLASH-radiotherapy) in radiotherapy. C57BL/6J mice were randomly divided into three groups: a sham group, a FLASH-irradiated group, and a CONV-irradiated group. A whole-body irradiation with a single dose of 3 Gy (200 Gy/s for FLASH group and 0.3 Gy/s for CONV group) using electron rays was used to establish models of lung injury. After 3 months, lung tissues were stained with HE and Masson stains to observe pathological changes in lung tissue and subjected to 4D-Fast DIA quantitative proteomics, with the sequencing data validated by Western blot and immunofluorescence. The mice in FLASH group had less lung tissue damage and lower levels of fibrosis compared to the CONV group. Proteomic sequencing showed significant differences in CCT6b protein expression between the two irradiation groups. As verified by the WB and immunofluorescence assays, the expression level of CCT6b was significantly reduced in the CONV group of mice compared with the SHAM and FLASH groups. With the down-regulation of CCT6b, there was a notable decrease in the expression of E-cadherin, accompanied by an increase in the expression of α-smooth muscle actin and Vimentin. The differential response in the level of lung fibrosis caused by the two types of radiation may be related to the level of CCT6b expression, but the specific mechanism of action needs to be further investigated. - Source: PubMed
Publication date: 2025/02/13
Li MengHuaZhang LiHuiGao AnNingXu JingWang XinYuLiu XiaoManYan DongFeiZou DongFangWu ShuangSun BinDong GuoFuWang ChangZhen - Laryngeal cancer (LC) is a prevalent head and neck malignancy; however, the essential pathophysiological mechanism underlying its tumorigenesis and progression remains elusive. Due to the perduring scarcity of effective targeted drugs for laryngeal cancer, insights into the disease's pathophysiological mechanisms would substantially impact the treatment landscape of laryngeal cancer. - Source: PubMed
Publication date: 2022/10/10
Liu BingHu YuqiangWan LixiaWang LuanCheng LiangjunSun HaiLiu YaranWu DiZhu JiefeiHong XiuLi YangZhou Chong - The genetic landscape of male infertility is highly complex. It is estimated that at least 4000 genes are involved in human spermatogenesis, but only few have so far been extensively studied. In this study, we investigated by whole exome sequencing two cases of idiopathic non-obstructive azoospermia (NOA) due to severe hypospermatogenesis. After variant filtering and prioritizing, we retained for each patient a homozygous loss-of-function (LoF) variant in a testis-specific gene, (c.250C>T; p.Gln84Ter) and (c.615-2A>G), respectively. Both variants are rare according to the gnomAD database and absent from our local control cohort ( = 445). To verify the implication of these candidate genes in NOA, we used the CRISPR/Cas9 system to invalidate the mouse orthologs and and produced two knockout (KO) mouse lines. Sperm and testis parameters of homozygous KO adult male mice were analyzed and compared with those of wild-type animals. We showed that homozygous KO males were fertile and displayed normal sperm parameters and a functional spermatogenesis. Overall, these results demonstrate that not all genes highly and specifically expressed in the testes are essential for spermatogenesis, and in particular, we conclude that bi-allelic variants of and are most likely not to be involved in NOA and male fertility. - Source: PubMed
Publication date: 2021/12/30
Cazin CarolineNeirijnck YasmineLoeuillet CorinneWehrli LydiaKühne FrançoiseLordey IsabelleMustapha Selima Fourati BenBouker AminZouari RaoudhaThierry-Mieg NicolasNef SergeArnoult ChristopheRay Pierre FKherraf Zine-Eddine - Hypereosinophilic syndrome is a rare disorder arising from neoplastic, or idiopathic causes. The availability of NGS panels has increasingly identified rare mutations as underlying pathogenic events and have led to reclassification of cases of idiopathic hypereosinophilic syndrome as chronic eosinophilic leukemia(CEL). In this report, we describe a case of a young man with hypereosinophilia whose disease initially did not fit the WHO criteria for CEL but harbored a rare mutation in gene. We report our experience in successfully treating this patient with multiple tyrosine kinase inhibitors and provide literature review of this rare entity including potential treatment strategies. - Source: PubMed
Publication date: 2021/11/02
Singh AbhayBaron JeffreySingh NamrataPeringeth GopisreeWang Eunice S