Ask about this productRelated genes to: KCND3 Blocking Peptide
- Gene:
- KCND3 NIH gene
- Name:
- potassium voltage-gated channel subfamily D member 3
- Previous symbol:
- SCA22, SCA19
- Synonyms:
- Kv4.3, KSHIVB
- Chromosome:
- 1p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-05
- Date modifiied:
- 2019-04-23
Related products to: KCND3 Blocking Peptide
Related articles to: KCND3 Blocking Peptide
- Source: PubMed
- Hybridization is a powerful evolutionary force for genetic improvement, conferring growth advantages and enhanced disease resistance. However, molecular basis of heterosis, especially when mediated by brain-derived neural regulation, remains unclear. To elucidate this, comparative brain transcriptome analysis was performed on red crucian carp, white crucian carp, their hybrid WR, and the backcross-improved WR-II. Our results revealed significant transcriptional changes between parents and their hybrids, leading to the identification of widespread differentially expressed genes (DEGs). Hierarchical clustering and quantitative mid-parent value analysis of DEGs revealed additive expression patterns in WR, whereas WR-II exhibited maternal bias in expression patterns. These DEGs were significantly enriched in pathways related to immune response, neural development, synaptic signaling, and insulin regulation. Weighted gene co-expression network analysis identified eight modules; one module significantly correlated with WR-II (r > 0.5, p < 0.01) contained the highest number of hub genes, totaling 71 (absolute kME value > 0.9). Protein-protein interaction network further highlighted key hub genes in WR-II, including NeuroD1, Rims2, KCND3, Gpc3, and MAPK13, exhibiting above the higher parent expression compared to parents. The encoded proteins form integrated networks central to insulin synthesis and secretion, neuronal excitability, growth regulation, and immune modulation. These findings provide new insights into neural mechanisms that contribute to heterosis in fish. - Source: PubMed
Publication date: 2026/05/26
Li RuZhang JipengWang JunZhou YiWang ChenghuiLiu Dong - Growth and egg production are the two most economically important traits in goose production systems. However, negative genetic correlations between these traits make it difficult to achieve balanced genetic improvement through selection. In this study, we analyzed whole-genome resequencing data from 1033 Zhedong White Geese to identify genetic variants related to birth weight (BW), body weight at 90 days (BW90), and egg number at 66 weeks of age (EN66). Single-trait genome-wide association studies (GWASs) identified 6, 5, and 5 lead SNPs significantly associated with BW, BW90, and EN66, respectively. By integrating network analysis, PLACO, and multivariate linear mixed models (mvLMMs), we further identified and as potential pleiotropic candidate genes influencing both growth and egg production. Notably, the variant at CHR25: 6006715, located within an intronic region of , was associated with increased BW (ZscoreBW = 4.44) and decreased EN66 (ZscoreEN66 = -3.55), showing strong pleiotropic significance (P_PLACO = 4.88 × 10). Collectively, these findings provide new insights into the genetic architecture underlying the antagonistic relationship between growth and egg production in geese and offer valuable genetic targets for developing breeding strategies that jointly optimize growth performance and reproductive efficiency. - Source: PubMed
Publication date: 2026/04/01
Zhou WeiPan JianhongZhou ShihengYang JingjingWang LinfangLi PanZhang ChunyuanJiang ZhihaoWu PanxueRen JindongLi RongyangLu LizhiChen LiZhang Zhenyang - The present study aimed to discover novel KChIP ligands as pharmacological tools for modulating the K4.3/KChIP channels. A multidisciplinary approach, combining medicinal chemistry and electrophysiology studies, led to the successfully identification of a novel K4.3/KChIP modulator (IQM-22110). Its design was guided by the previous knowledge of the (phenylacetamido)benzoic acid moiety as suitable scaffold, along with virtual screening of a focused chemical library that suggested improved KChIP3 binding upon incorporation of an additional aromatic ring. IQM-22110 was selected for synthesis and identified as a potent KChIP3 ligand. Its electrophysiological effects on K4.3/KChIP3 currents indicate that IQM-22110 binds to a high affinity site in K4.3/KChIP3 channels that it is not present in K4.3/KChIP2 or K4.3. To the best of our knowledge, here we describe the first KChIP3 ligand that selectively modulates K4.3/KChIP3 versus K4.3/KChIP2 and K4.3 channels at nanomolar concentration. Since KChIP2 is predominantly expressed in cardiac tissue, this selectivity may enable the development of K4.3/KChIP3-targeted therapeutics with reduced risk of cardiac side effects. Computational and site-directed mutagenesis studies allowed the identification of IQM-22110's binding site on KChIP3. Knowledge gained from structural and functional studies with this novel KChIP3 ligand could establish the basis for drug discovery programs fostering treatments for diseases in which K4.3/KChIPs channels are involved. - Source: PubMed
Publication date: 2026/03/21
Socuellamos Paula GViedma-Barba Carmende Benito-Bueno AngelaBonache Maria AngelesRopero MariaDiez SaraElizalde PabloMarín-Olivero IreneRedondo-Moya MariaNaranjo Jose RamonGonzalez-Vera Juan AOrte AngelPerez-Lara AngelMartin-Martinez MercedesValenzuela CarmenGutierrez-Rodriguez Marta - : Cardiac arrhythmias are among the leading causes of sudden cardiac death (SCD). Pathogenic variants in potassium channel genes play a key role in inherited arrhythmia syndromes, yet their contribution in Central Asian populations remains poorly characterized. : We performed targeted next-generation sequencing (NGS) using a 96-gene custom Haloplex panel in 79 Kazakhstani patients with clinically diagnosed arrhythmias, including atrioventricular block, sick sinus syndrome, and atrial fibrillation. Detected variants in potassium channel genes were classified according to ACMG guidelines and correlated with clinical phenotypes. : A total of 52 variants were identified across 11 potassium channel genes. Two likely pathogenic variants ( p.Cys66Gly and p.Arg176Trp) and six variants of uncertain significance (VUS) in , , , and were detected. Two novel previously unreported variants were found in and Patients harboring pathogenic variants commonly presented with early-onset arrhythmias or a positive family history of cardiovascular disease. Carriers of variants exhibited mild QT prolongation and recurrent syncope. : This is the first genetic study of potassium channel gene mutations in Kazakhstani patients with cardiac arrhythmias. The detection of pathogenic and novel variants highlights the clinical utility of integrating genetic testing into diagnostic and management pathways for arrhythmia syndromes. Population-specific genomic data are essential for improving risk stratification, guiding medication safety, and enabling cascade family screening in Central Asia. - Source: PubMed
Publication date: 2026/01/26
Chamoieva AyaulymRakhimova SauleAbilova ZhannurAkhmetova AinurAkilzhanova GulbanuZhalbinova MadinaDaniyarov AssetAkilzhanov KenesMolkenov AskhatKairov UlykbekKuanysheva AnargulShaimardanov NurlanAbdrakhmanov AyanBekbossynova MakhabbatAkilzhanova Ainur