MAK10 Blocking Peptide
- Known as:
- MAK10 Blocking Peptide
- Catalog number:
- 33r-9389
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- MAK10 Blocking Peptide
Related genes to: MAK10 Blocking Peptide
- Gene:
- NAA35 NIH gene
- Name:
- N(alpha)-acetyltransferase 35, NatC auxiliary subunit
- Previous symbol:
- MAK10
- Synonyms:
- FLJ21613, FLJ22643, bA379P1.1
- Chromosome:
- 9q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-11
- Date modifiied:
- 2016-10-05
Related products to: MAK10 Blocking Peptide
Related articles to: MAK10 Blocking Peptide
- Cancer cachexia is a complex syndrome marked by weight loss and muscle wasting, significantly impacting patient quality of life and survival. Mechanistically, it is characterized by suppressed protein synthesis and enhanced muscle catabolism, with the role of endoplasmic reticulum (ER) stress and unfolded protein response (UPR) becoming increasingly evident. This study aimed to explore ER stress-tolerant factors in muscle wasting and evaluate their potential to prevent muscle loss in cancer cachexia. - Source: PubMed
Kaneko YusakuHino TomohiroTaminishi ShuntaMatoba YayoiMotooka DaisukeHoshino AtsushiMatoba Satoaki - Histone acetyltransferases (HATs) catalyse the addition of acetyl groups to histones and other proteins. In contrast, histone deacetylases remove acetyl groups from core histones, and the activity of these enzymes maintains the acetylation levels of these proteins. Histone acetylation levels influence chromatin accessibility and gene expression and regulate many biological processes, including development and reproduction. Recent reports suggest that some N-terminal acetyltransferases (NATs) also regulate gene expression. We identified 29 HAT and NAT genes in the red flour beetle, Tribolium castaneum, and studied their functions in female reproduction using RNA interference (RNAi). Knockdown of seven out of 13 HAT genes (N-acetyltransferase ESCO2) (ESCO1/2), Elongator complex protein 3 (ELP3), Histone acetyltransferase type B catalytic subunit 1 (HAT1), Transcription initiation factor TFIID subunit 1 (TAF1), Protein x-mas-2 (MCM3AP), Histone acetyltransferase Tip60 (KAT5), and Cysteine-rich protein 2-binding protein (KAT14) and 12 out of 16 NAT genes Probable glucosamine 6-phosphate N-acetyltransferase (GNPNAT1), N-alpha-acetyltransferase 10 (NAA10), N-alpha-acetyltransferase 20 (NAA20), N-alpha-acetyltransferase 30 (NAA30), N-alpha-acetyltransferase 40 (NAA40), N-alpha-acetyltransferase 60 (NAA60), N-acetyltransferase 6 (NAA80), RNA cytidine acetyltransferase (NAT10), Diamine acetyltransferase 2 (SATL1), N(alpha)-acetyltransferase 16 (NAA16), Phagocyte signalling-impaired protein (NAA25), N(alpha)-acetyltransferase 35 (NAA35) caused a significant reduction in eggs laid by females compared to the eggs laid by control females injected with dsGFP. Also, knockdown of nine (KAT5, ATAT1, ELP3, HAT1, KAT8A, NAA10, NAA20, GNPNAT1 and TAF1) HAT/NAT genes caused a significant decrease in egg hatching. Parental RNAi of ATAT1 and KAT8 blocked embryogenesis. These data suggest that the acetylation of proteins plays an important role in female reproduction and embryogenesis. - Source: PubMed
Publication date: 2025/05/29
Sengodan KarthiPalli Subba Reddy - The crossbreeding of specialized beef cattle breeds with Chinese indigenous cattle is a common method of genetic improvement. Xia'nan cattle, a crossbreed of Charolais and Nanyang cattle, is China's first specialized beef cattle breed with independent intellectual property rights. After more than two decades of selective breeding, Xia'nan cattle exhibit a robust physique, good environmental adaptability, good tolerance to coarse feed, and high meat production rates. This study analyzed the population genetic structure, genetic diversity, and genomic variations of Xia'nan cattle using whole-genome sequencing data from 30 Xia'nan cattle and 178 published cattle genomic data. - Source: PubMed
Publication date: 2024/06/05
Song XingyaYao ZhiZhang ZijingLyu ShijieChen NingboQi XingshanLiu XianMa WeidongWang WushengLei ChuzhaoJiang YuWang EryaoHuang Yongzhen - Driven by natural and artificial selection, the domestic Huoyan geese from Northern China have gradually generated specific phenotypes and climatic adaptations. To understand the genetic basis of the two specific phenotypes that are sex linked, including upper eyelid coloboma and gosling feather color, as well as the climatic adaptations of the Huoyan goose, which can contribute to the artificial selection and breeding of geese. We selected Huoyan geese and nine Southern Chinese goose breeds and identified their divergence on the genomic level. Using selective sweep analysis, we found that on chromosome Z influences the upper eyelid coloboma phenotype of the Huoyan goose, and is a plausible candidate gene for the Huoyan gosling feather color. We obtained a number of genes related to cold adaptation in Huoyan geese, mainly involved in physiological functions such as metabolism, angiogenesis contraction and circulatory system, apoptosis, immunity, stress, and neural system. The most interesting candidates for cold adaptation are and that are associated with energy metabolism and stress. We also obtained some genes related to heat adaptation, including , associated with neurology; , associated with skin pigmentation; and , associated with apoptosis. These findings deepen our understanding of the genetics of specific phenotypes and climate adaptation in local geese and provide insights for the selection of goose breeds. - Source: PubMed
Publication date: 2023/11/22
Wen JunhuiYu JinchengZhang LiLi HaiyingWang HuieGu HongchangZhao XiurongZhang XinyeRen XufangWang GangChen AnqiQu Lujiang - Most human proteins are N-terminally acetylated by N-terminal acetyltransferases (NATs), which play crucial roles in many cellular functions. The NatC complex, comprising the catalytic subunit NAA30 and the auxiliary subunits NAA35 and NAA38, is estimated to acetylate up to 20% of the human proteome in a co-translational manner. Several NAT enzymes have been linked to rare genetic diseases, causing developmental delay, intellectual disability, and heart disease. Here, we report a de novo heterozygous NAA30 nonsense variant c.244C>T (p.Q82*) (NM_001011713.2), which was identified by whole exome sequencing in a 5-year-old boy presenting with global development delay, autism spectrum disorder, hypotonia, tracheal cleft, and recurrent respiratory infections. Biochemical studies were performed to assess the functional impact of the premature stop codon on NAA30's catalytic activity. We find that NAA30-Q82* completely disrupts the N-terminal acetyltransferase activity toward a classical NatC substrate using an in vitro acetylation assay. This finding corresponds with structural modeling showing that the truncated NAA30 variant lacks the entire GNAT domain, which is required for catalytic activity. This study suggests that defective NatC-mediated N-terminal acetylation can cause disease, thus expanding the spectrum of NAT variants linked to genetic disease. - Source: PubMed
Publication date: 2023/06/30
Varland SylviaBrønstad Kirsten MarieSkinner Stephanie JArnesen Thomas