Ask about this productRelated genes to: MDH2 Blocking Peptide
- Gene:
- MDH2 NIH gene
- Name:
- malate dehydrogenase 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 7q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2015-11-13
Related products to: MDH2 Blocking Peptide
Related articles to: MDH2 Blocking Peptide
- Prenatal exposure to opioids such as morphine poses significant risks to fetal neurodevelopment, particularly in brain regions critical for cognition, such as the hippocampus. Despite the prescription and use of opioids during pregnancy, the molecular and histological consequences of such exposure remain insufficiently explored. To evaluate the effects of short-term prenatal morphine exposure on the expression of key neurodevelopmental genes and the structural integrity of the hippocampus in neonatal rats. - Source: PubMed
Nadri PooyaDaneshfar ZahraAzarmehr ZahraFarrokhfar Samaneh - Abnormal glycolysis drives colorectal cancer (CRC) progression. Curcumin (Cur) has anti-CRC activity, but its effect on glycolysis remains unclear. This study explores Cur's regulation of glycolysis in CRC cells. - Source: PubMed
Publication date: 2026/03/26
Zhao YuweiQin HaoSun WeiChen YuWang RuoyuLi Chuang - Cisplatin resistance is a major obstacle in the treatment of non-small cell lung cancer (NSCLC) and remains a leading cause of cancer-related deaths worldwide. This resistance substantially reduces the efficacy of cisplatin and highlights the need for innovative therapeutic strategies. - Source: PubMed
Publication date: 2026/03/17
Zhu ManTang XiaoyuZhu ZerenTang WenjunCheng YumengTang WenjuanZhang QianqianQin LongyuZhang SuyuZhang Yanmin - In vitro experiments have contributed to numerous fields of knowledge, including fish skeletal muscle. Despite improved strategies, in vitro assays still show discrepancies with in vivo systems, especially for non-model organisms. In this sense, we characterized the transcriptional profile of pacu (Piaractus mesopotamicus) muscle cells in vitro and in vivo. Processes related to proliferation, glycolytic metabolism, and extracellular matrix were enriched in vitro, while energy production, muscle contraction, and amino acid processing were enriched in vivo. Through qPCR, the genes fn1a (fibronectin 1a), hk1 (hexokinase 1), and ctnnb1 (catenin beta 1), respectively related to extracellular matrix, glycolytic metabolism, and cell proliferation and differentiation, were highly expressed in vitro. The genes ckma (creatine kinase, muscle a), acat1 (acetyl-CoA acetyltransferase 1), mdh2 (malate dehydrogenase 2), and pkmb (pyruvate kinase M1/2b), respectively associated with ATP production, fatty acid oxidation, oxidative and glycolytic metabolism, and the genes musk (muscle, skeletal, receptor tyrosine kinase), chrna1 (cholinergic receptor, nicotinic, alpha 1) and clu (clusterin), involved in cell signaling, were highly expressed in vivo. Overall, our results indicate that the main limitation of in vitro muscle cell model is the maintenance of an embryonic-like molecular state, whereas in vivo muscle displays a mature transcriptional profile, providing a molecular basis to guide future strategies for improving fish muscle cell culture systems and supporting advances in sustainable aquaculture and in vitro meat production. - Source: PubMed
Publication date: 2026/03/10
Zanella Bruna Tereza ThomaziniPerez Érika StefaniDos Santos Barbosa Mirely FrancineValente Jéssica SilvinoDuran Bruno Oliveira SilvaDal-Pai-Silva Maeli - To score pheochromocytoma and paraganglioma (PPGL) by using the composite pheochromocytoma and paraganglioma grading system (COPPS), to analyze the correlations of COPPS, the pheochromocytoma of the adrenal gland scaled score (PASS), and the grading system for adrenal pheochromocytoma and paraganglioma (GAPP) with tumor metastasis or recurrence and to explore the relationship between gene mutations and metastasis or recurrence in some PPGL. Clinicopathological data of the 186 paragangliomas diagnosed from January 2012 to December 2022 at Beijing Friendship Hospital, Beijing, China, the Peking University Third Hospital, Beijing, China, and the First Affiliated Hospital of Shihezi University, Shihezi, China were collected and analyzed. Predictive values of the three systems for tumor metastasis or recurrence were evaluated. Immunohistochemistry was performed using the EnVision staining method. Whole-exome sequencing was used to detect gene mutations in 15 tumors. Among the 186 PPGL patients, there were 93 females and 93 males, age 49 (47, 50) years old. Metastasis or recurrence occurred in 60 cases. 34 of the tumors were located in the retroperitoneum. The maximum tumor diameter was >7 cm in 42 cases. A COPPS score ≥3 was observed in 97 cases (52.2%, 97/186), among whom 53 cases (54.6%, 53/97) experienced metastasis or recurrence. The metastasis/recurrence rate in the COPPS score≥3 group was significantly higher than that in the <3 group (=46.469,<0.001). Tumor location in the retroperitoneum, presence of large nests of cells, pathological mitosis, spindle cells, capsular invasion, and fat infiltration were all associated with a COPPS score ≥3 (=18.370, 51.730, 8.914,18.750, 62.481, 19.354, all <0.05). The sensitivity of COPPS for predicting metastasis/recurrence was 88.3% (53/60), while the specificity was 65.1% (82/126). Negative expression of SDHB was observed in 50 cases, and negative expression of S-100 protein was observed in 96 cases. DNA extraction failed to produce qualified DNA in 3 cases; among the remaining 12 tumors that were subject to DNA extraction, 739 mutations (in 658 genes) were detected, including 300 germline mutations (in 265 genes) and 439 somatic mutations (in 408 genes). Related pathogenic germline mutation genes occurred on: SDHA, MDH2, MEN1, EGLN1, RET and SDHB. All 12 patients had more than four pathogenic germline mutations. Somatic pathogenic mutation genes included ATRX, KIF1B, EPAS1, HRAS, NF1, and MAML3. A higher COPPS score (≥3 versus <3) is associated with a higher metastasis/recurrence rate. Its sensitivity for predicting tumor metastasis/recurrence is higher than that of GAPP, while its specificity is higher than that of PASS. The combined use of negative SDHB and S-100 protein expression with COPPS could be used to stratify the risk of metastasis/recurrence in PPGL. - Source: PubMed
Wang L LYang S MWei X JSong L XZhang Q CZhao J MCheng MLi F