Ask about this productRelated genes to: PRKCI Blocking Peptide
- Gene:
- PRKCI NIH gene
- Name:
- protein kinase C iota
- Previous symbol:
- DXS1179E
- Synonyms:
- PKCI
- Chromosome:
- 3q26.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-06
- Date modifiied:
- 2016-10-05
Related products to: PRKCI Blocking Peptide
Related articles to: PRKCI Blocking Peptide
- The histopathological and genomic landscape of thyroid tumors is well-characterized, although new genetic alterations and tumor types are being described. We present two cases of thyroid tumors originating from follicular cells that had highly unusual and distinct morphological features and carried an OCLN::PRKCI gene fusion. These tumors were well-circumscribed and encapsulated and composed of irregularly shaped tubular and follicular structures surrounded by layers of distinct fibro-collagenous basement membrane material positive for type IV collagen and laminin; they showed no definitive nuclear features of papillary carcinoma. Importantly, while one of the tumors had no invasive growth, the other demonstrated tumor capsule invasion, compatible with the adenoma-carcinoma spectrum seen in thyroid follicular and oncocytic tumors. The gene expression profiles of these tumors differed from those of common types of papillary thyroid carcinoma. The unusual and reproducible histopathologic characteristics and unique molecular profiles of these tumors support their designation as a distinct type of thyroid neoplasm that exists in non-invasive and invasive forms, and therefore can be designated as fibro-tubular adenoma and carcinoma. Recognition of this distinct entity is important for improving diagnostic accuracy and avoiding overtreatment of this likely indolent type of thyroid neoplasia. - Source: PubMed
Publication date: 2026/05/12
Hahn ElanNikitski Alyaksandr VWald Abigail ISeethala Raja RChiosea Simion IPeel Robert LNikiforov Yuri E - Peutz-Jeghers syndrome (PJS) is a rare inherited cancer predisposing disorder associated with pathogenic variants of the Serine Threonine Kinase11 (STK11 / LKB1). Morbidity in children is driven by small intestinal obstruction from polyps. The molecular mechanisms driving polyp initiation and growth are poorly understood. We hypothesized that integrated phosphoproteomic analysis of pediatric Peutz-Jeghers polyps would reveal signaling networks driving polyp growth. - Source: PubMed
Publication date: 2026/05/04
Pushel IrinaRoy Badal CNolte Whitney MHarvey LisaBagherian AmberRekowski Michaella JClark Zachary DWashburn Michael PUmar ShahidAttard Thomas M - Mother-to-child disease transmission begins in utero, with the placenta playing a critical role in pregnancy and offspring health. Uterine leiomyomata (fibroids, UFs) and endometriosis (ENDO) are common gynecologic diseases that have substantial overlaps in symptomology and risk factors, however drivers of disease risk remain unclear. The objective of this study was to investigate shared placental genetic associations across ENDO and UFs. - Source: PubMed
Publication date: 2026/04/01
Akerele Alexis THampton GabrielleKim JeewooJaworski JamesLewis Toni JKhan AtlasRasmussen-Torvik Laura JLuo YuanJasper Elizabeth AHellwege Jacklyn NEdwards Todd LVelez Edwards Digna R - Head and neck cancer (HNC) represents the seventh most common cancer diagnosis globally, yet current treatments, including surgery, radiation, and immunotherapy, have shown limited improvement in outcomes. Drug repurposing offers a cost-effective strategy to identify new therapeutic options by leveraging existing medications with known safety profiles. Within this study, we developed the pipeline (enomic lteration-based epurposing for rugs), designed to uncover repurposing candidates for HNC using genomic and network-based approaches. : GARD integrates multi-omics data from The Cancer Genome Atlas (TCGA), including copy number variation (CNV) and somatic mutations (SOM). The cohort was stratified by human papillomavirus (HPV) status. Risk-associated genes were identified and then expanded via high-confidence protein-protein interaction (PPI) networks. Top candidate genes were filtered through comprehensive analysis of publicly available literature data in PubMed using LLMs to validate the relationship between the identified genes and HNC. The top risk genes and their network-expanded neighbors were mapped against DrugBank, and through statistical significance testing and literature validation, established significant drug-gene associations. : Significant genes associated with HNC, inferred by genomics alteration, were identified across HPV-positive and HPV-negative subgroups, such as PIK3CA, SOX2, TP53, EIF4G1, TLR7, CLDN1, PRKCI, and EPHA2. Further expansion through the PPI network identified other targetable genes such as EGFR, ERBB2, and the FGFRs. Literature-based validation efforts ensured confidence in the gene-disease association. Drug-gene mapping revealed candidates spanning those already in clinical trials for HNC (e.g., Afatinib, Cabozantinib, Dasatinib, Brigatinib, Lenvatinib, Capivasertib, and Erdafitinib) and emerging or repurposing candidates (Amuvatinib, XL765 (Voxtalisib), Golotimod, Artenimol, Quercetin, and Acetylsalicylic Acid), offering opportunities for precision repurposing. : The GARD pipeline demonstrates a genomics-driven, network-informed framework for systematic drug repurposing in HNC. HPV stratification enhances precision, literature-based validation strengthens confidence, and integrated drug mapping enables refinement of existing therapies and discovery of novel candidates for personalized treatment strategies. : The full implementation of the GARD pipeline, including preprocessing scripts, statistical analysis modules, and visualization tools, is publicly available on GitHub. - Source: PubMed
Publication date: 2026/02/26
Tanikella PradhamNenad WilliamCourtine ChristopheDai YifanDeng QingyingZou BaimingOsazuwa-Peters NosayabaSchrank Travis PWu Di - The genus , classified within the family Sciuridae and the subfamily Callosciurinae, is distributed across East and Southeast Asia. The taxonomic classification of has historically been contentious, with species diversity often underestimated due to reliance on pelage color variations for species descriptions, which are thought to reflect seasonal changes. To clarify the internal phylogenetic relationships and taxonomic status of the species, we conducted morphological analyses and constructed multi-locus phylogenetic trees using a large DNA dataset that encompassed one mitochondrial locus (Cyt-b) and three nuclear loci (IRBP, PRKCI, RAG1), as well as 20 complete mitochondrial genomes. We identified seven well-supported monophyletic clades of based nuclear data evidence. The K2P genetic distances among the seven lineages of varied from 0.095 to 0.204. Consequently, we elevated one subspecies . to full species status, having diverged from its common ancestor approximately 6.01 million years ago. Ultimately, we recognized a total of seven valid species within the genus , which include . , . , . , . , . , . , and . . Divergence time estimation suggested that began to diversify approximately 13.3 million years ago (Mya). Our findings provide insights into the evolutionary relationships and previously overlooked species diversity within the genus . - Source: PubMed
Publication date: 2026/02/11
Zou YanHui LangeHuang WenhaoJi RongTang XinyuWang XumingChen ShundeLi SongLiu ShaoyingTang Keyi