Ask about this productRelated genes to: FZD9 Blocking Peptide
- Gene:
- FZD9 NIH gene
- Name:
- frizzled class receptor 9
- Previous symbol:
- -
- Synonyms:
- FZD3, CD349
- Chromosome:
- 7q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-17
- Date modifiied:
- 2015-09-11
Related products to: FZD9 Blocking Peptide
Related articles to: FZD9 Blocking Peptide
- Comparative sociogenomics combines multiple scientific fields to investigate the genetic basis of social behavior across species. Our aim was to uncover the genetic roots of human sociability with possible implications for autism, a neurodevelopmental disorder characterized by social and communication deficits. - Source: PubMed
Publication date: 2026/03/25
Chiodi AliceMosca EttoreCupaioli Francesca AnnaMezzelani Alessandra - Williams syndrome (WS; OMIM #194,050) is a multisystem pediatric genetic disorder caused by a heterozygous microdeletion of a 1.5-1.8 Mb region at chromosome 7q11.23, encompassing 26 to 28 genes. Clinical hallmarks include cardiovascular anomalies, distinctive craniofacial morphology and neurodevelopmental deficits characterized by hypersociability, cognitive impairment and anxiety. Although causative therapies for WS still remain elusive, advances in gene editing and forebrain organoids have already greatly furthered our understanding of the underlying mechanisms. - Source: PubMed
Publication date: 2026/03/17
Chen Ya-YueChen Wei-JunZhang RuiJi ChaiZhang Yu-HanMa Da-QingShi Qiao-JuanXie Yi-Cheng - The Wnt/Frizzled signaling pathway is implicated in tumor progression, yet the expression patterns and regulatory dynamics of Frizzled class receptor 9 (FZD9) in breast cancer remain poorly defined. This study evaluated FZD9 protein expression in breast tumors and explored its transcriptional modulation in breast cancer cell lines exposed to cytotoxic and epigenetic agents. Immunohistochemical analysis was performed in 81 breast cancer cases representing major molecular subtypes. In parallel, breast cancer cell lines were treated with trichostatin A, 5-aza-2'-deoxycytidine, cisplatin, doxorubicin, paclitaxel, and ionizing radiation, followed by quantification of FZD9 mRNA levels by RT-qPCR. FZD9 protein expression was more frequent in HER2-enriched tumors, cases with high Ki-67 index, and advanced T-stage. FZD9-positive tumors were associated with reduced overall survival, whereas relapse-free survival showed no significant difference. Baseline FZD9 transcript levels varied substantially across cell lines, and transcriptional responses to chemotherapy, radiation, and epigenetic treatment were highly context-dependent, with divergent patterns observed according to molecular background. Collectively, these findings indicate that FZD9 expression in breast cancer is heterogeneous, associated with aggressive clinicopathological features, and dynamically modulated by therapeutic exposures, supporting its consideration as an exploratory marker of tumor aggressiveness and therapy-related biological responses. - Source: PubMed
Bastos Daniel Rodrigues deCintra Ricardo CesarLongatto-Filho AdhemarTermini Lara - Coleoid cephalopods are excellent models for evolutionary and developmental studies due to their centralized nervous system, short life span, and sophisticated sense organs. Arm suckers, essential for predation, manipulation, and locomotion, have been studied in Decapodiformes, but little is known at the cellular and molecular levels. Here, we investigated sucker development in from the embryo to the juvenile stage using morphological, histological, immunostaining, scanning electron microscopy (SEM), in situ hybridization, and transcriptomic analyses. SEM revealed that suckers initially form symmetrically and later become asymmetrical through an embedding process. Histology showed progressive structural differentiation, while immunostaining with acetylated α-tubulin and phalloidin visualized nerve fiber and muscle development. Transcriptome profiling of embryonic stages 12, 14, and 20 identified 2,349 differentially expressed genes (DEGs) linked to arm and muscle development. Among them, , , and WNT signaling molecules (, , ) exhibited increased expression in arms and developing suckers, consistent with in situ hybridization results. These findings suggest that WNT signaling contributes to sucker muscle development in , paralleling its conserved role in vertebrates. This study provides new insights into the embryonic morphogenesis of arms and suckers, highlighting the molecular and cellular mechanisms that shape cephalopod appendages. - Source: PubMed
Publication date: 2026/03/04
Kim YeonjiLee Chan-JunRyu Kyoung-BinAryal Yam PrasadJo SeonmiSeo Dae-CheolSong Ji-HoonJeong Byeong-GilLee Mi-JinAn Shin-HongJung Seung-HyunLee Hae-YounCho Sung-Jin - Recent studies suggest a potential comorbidity between Parkinson's disease (PD) and Ulcerative Colitis (UC), with epidemiological evidence indicating that smoking reduces the risk of both conditions. However, the underlying mechanisms remain unclear. In this study, we aimed to identify key genes involved in the shared pathological mechanisms of PD and UC and to validate their functional relevance. We also explored the therapeutic potential of nicotinic acetylcholine receptors (nAChRs) in both diseases. Using gene expression profiles, we identified UC was characterized by broader cytokine secretion, while PD exhibited specific loss of neuronal interneurons. We identified four genes - FZD9, FGR, SLC7A5, and BATF3 - as key diagnostic markers for both diseases. Notably, we observed dysregulation of α7nAChR which was associated with alterations in Wnt signaling and depletion of neuronal interneurons. CHRNA7 expression and Wnt signaling pathways correlated with the four key genes in both PD and UC datasets. In murine models, nicotine alleviated motor deficits in PD and reduced colitis severity in UC, restoring the WNT2-FZD9-β-catenin signaling pathway. Our findings highlight a shared pathological mechanism between PD and UC and suggest that α7nAChR may serve as a potential therapeutic target through modulation of Wnt signaling and inflammatory responses in both diseases. - Source: PubMed
Publication date: 2025/07/01
Li YingyanGu YuhanLi JunLiu FanglinChen HuanHou HongweiHu Qingyuan