Ask about this productRelated genes to: SLC44A3 Blocking Peptide
- Gene:
- SLC44A3 NIH gene
- Name:
- solute carrier family 44 member 3
- Previous symbol:
- -
- Synonyms:
- MGC45474, CTL3
- Chromosome:
- 1p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-09-06
- Date modifiied:
- 2016-10-05
Related products to: SLC44A3 Blocking Peptide
Related articles to: SLC44A3 Blocking Peptide
- To investigate glycosphingolipid biosynthesis (GSB) dysregulation in uveal melanoma (UVM) and develop a machine learning-driven prognostic signature bridging GSB activity, tumor microenvironment, and clinical outcomes. - Source: PubMed
Publication date: 2026/01/27
Guo HaoranLi BaiZhang ZhiChen Junjie - Hepatocellular carcinoma (HCC), a prevalent malignant neoplasm, presents significant therapeutic challenges. However, the key factors and mechanisms driving HCC metastasis remain incompletely understood. This study aimed to elucidate the mechanism through which CHML regulates the migration and invasion of HCC cells. - Source: PubMed
Publication date: 2025/08/06
Cao HuanqianWang SiyuZhang LiXie HeyingLiu YiqiongKong RuijiaoJia YinLu LingJiang JunfengLiu Shanrong - Sickle cell trait (SCT), although generally a benign carrier state of hemoglobin S (HbAS), is a risk factor for exertional rhabdomyolysis (ERM), a rare but potentially fatal consequence of highly intense physical exercise, particularly among active-duty military personnel and high-performance athletes. The association between SCT and ERM is poorly understood. The objective of this study was to elucidate the genetic basis of ERM in an SCT-positive African American cohort. SCT-positive African Americans with a personal history of ERM (cases, n = 30) and without history of ERM (controls, n = 53) were enrolled in this study. Whole-genome sequencing was performed on DNA samples isolated from peripheral white blood cells. Participants' demographic, behavioral, and medical history information was obtained. An additional 131 controls were extracted from SCT-positive subjects of African descent from the 1000 Genomes Project. SCT carriers with ERM were characterized by myotoxicity features, significant muscle involvement dominated by muscle weakness, and severe pain and substantial increase in serum creatine kinase, with a mean value of 50,480 U/L. A distinctive feature of the SCT individuals with ERM was exertional collapse, which was reported in 53.3% of the cases in the study cohort. An important factor for the development of ERM was the duration and frequency of strenuous physical activity in the cases compared to the controls. Whole-genome sequencing identified 79,696 protein-coding variants. Genome-wide association analysis revealed that the p.C477R, rs115958260 variant in the SLC44A3 gene was significantly associated with ERM event in SCT-positive African Americans. The study results suggest that a combination of vigorous exercise and a genetic predisposing factor is involved in ERM. - Source: PubMed
Publication date: 2024/03/26
Ren MingqiangSambuughin NyamkhishigMungunshukh OgnoonEdgeworth Daniel BaxterHupalo DanielZhang XijunWilkerson Matthew DDalgard Clifton LO'Connor Francis GDeuster Patricia A - Recently, studies on the mechanisms underlying lipid metabolic reprogramming in cancer have increased. However, its significance in cervical cancer remains unclear. In the present study, a prognostic signature was constructed for patients with cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) using the expression profiles of lipid metabolism-related genes (LMRGs). Furthermore, using various bioinformatics methods, a prognostic gene signature was developed for progression-free survival (PFS). This signature was externally validated using a cervical cancer dataset (GSE44001). The characteristics of the molecular subgroups of LMRGs were analyzed, and target LMRGs were identified via differential gene analysis of the expression profiles and weighted gene correlation network analysis. Thereafter, the identified target genes were used to develop the prognostic gene signature using univariate, least absolute shrinkage and selection operator, and multivariate Cox regression analyses. The performance of the LMRG signature was evaluated using Kaplan-Meier curves, time-dependent receiver operating characteristic curves, decision curve analysis, mutation landscapes, gene set enrichment analysis, and immune score calculation. As a result, a novel eight-LMRG signature comprising ALDH3B2, CERS3, FA2H, GLTP, NR1H3, PLIN3, SLC44A3, and SQLE was constructed. Using this gene signature, patients with CESC and significantly distinguished PFS were divided. This eight-LMRG signature exhibited independent prognostic potential and superior predictive performance compared with a previously developed 12-gene signature. Our findings suggest that our novel eight-LMRG signature contributes to the implementation of precision medicine strategies for managing patients with cervical cancer by facilitating CESC prognosis. - Source: PubMed
Publication date: 2023/09/25
Wang ShashaZhang Songying - To identify key enhancer RNAs (eRNA) in esophageal cancer through a comprehensive analysis and explore its importance in esophageal cancer. - Source: PubMed
Kang KaiWu JingyiMao YajunKai JindanChen SiXiong Fei