Ask about this productRelated genes to: DALRD3 Blocking Peptide
- Gene:
- DALRD3 NIH gene
- Name:
- DALR anticodon binding domain containing 3
- Previous symbol:
- -
- Synonyms:
- FLJ10496
- Chromosome:
- 3p21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-10
- Date modifiied:
- 2019-02-19
Related products to: DALRD3 Blocking Peptide
Related articles to: DALRD3 Blocking Peptide
- Craniomaxillofacial sutures play a critical role in craniomaxillofacial development through continuous bone reconstruction and regeneration, processes modulated by mechanical tension. Bone suture stem cells (SuSCs) are central to these functions. Distraction osteogenesis, which promotes craniomaxillofacial suture growth, is a common therapeutic approach for craniofacial deformities. However, the underlying mechanisms by which mechanical forces drive suture and bone remodeling remain poorly understood, posing significant clinical challenges. - Source: PubMed
Publication date: 2025/06/17
Chen JieZhao YiweiZeng ChongmaiTian GuoliFeng ZhicaiCao Yang - Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major histocompatibility complex (MHC) region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and the cortex, along with D and D type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 65 of 112 additional phenotypes, including all the psychiatric disorders we examined. In particular, OCD shared genetic risk with anxiety, depression, anorexia nervosa and Tourette syndrome and was negatively associated with inflammatory bowel diseases, educational attainment and body mass index. - Source: PubMed
Publication date: 2025/05/13
Strom Nora IGerring Zachary FGalimberti MarcoYu DongmeiHalvorsen Matthew WAbdellaoui AbdelRodriguez-Fontenla CristinaSealock Julia MBigdeli TimColeman Jonathan RMahjani BehrangThorp Jackson GBey KatharinaBurton Christie LLuykx Jurjen JZai GwynethAlemany SilviaAndre ChristineAskland Kathleen DBäckman JuliaBanaj NerisaBarlassina CristinaNissen Judith BeckerBienvenu O JosephBlack DonaldBloch Michael HBørte SigridBosch RosaBreen MichaelBrennan Brian PBrentani HelenaBuxbaum Joseph DBybjerg-Grauholm JonasByrne Enda MCabana-Dominguez JuditCamarena BeatrizCamarena AdrianCappi CarolinaCarracedo AngelCasas MiguelCavallini Maria CristinaCiullo ValentinaCook Edwin HCrosby JesseCullen Bernadette ADe Schipper Elles JDelorme RichardDjurovic SrdjanElias Jason AEstivill XavierFalkenstein Martha JFundin Bengt TGarner LaurynGironda ChristinaGoes Fernando SGrados Marco AGrove JakobGuo WeiHaavik JanHagen KristenHarrington KellyHavdahl AlexandraHöffler Kira DHounie Ana GHucks DonaldHultman ChristinaJanecka MagdalenaJenike EricKarlsson Elinor KKelley KaraKlawohn JuliaKrasnow Janice EKrebs KristiLange ChristophLanzagorta NuriaLevey DanielLindblad-Toh KerstinMacciardi FabioMaher BrionMathes BrittanyMcArthur EvonneMcGregor NathanielMcLaughlin Nicole CMeier SandraMiguel Euripedes CMulhern MaureenNestadt Paul SNurmi Erika LO'Connell Kevin SOsiecki LisaOusdal Olga TheresePalviainen TeemuPedersen Nancy LPiras FabrizioPiras FedericaPotluri SriramyaRabionet RaquelRamirez AlfredoRauch ScottReichenberg AbrahamRiddle Mark ARipke StephanRosário Maria CSampaio Aline SSchiele Miriam ASkogholt Anne HeidiSloofman Laura GSmit JanArtigas María SolerThomas Laurent FTifft EricVallada Homerovan Kirk NathanialVeenstra-VanderWeele JeremyVulink Nienke NWalker Christopher PWang YingWendland Jens RWinsvold Bendik SYao YinZhou Hang Agrawal ArpanaAlonso PinoBerberich GötzBucholz Kathleen KBulik Cynthia MCath DanielleDenys DamiaanEapen ValsammaEdenberg HowardFalkai PeterFernandez Thomas VFyer Abby JGaziano J MGeller Dan AGrabe Hans JGreenberg Benjamin DHanna Gregory LHickie Ian BHougaard David MKathmann NorbertKennedy JamesLai DongbingLandén MikaelHellard Stéphanie LeLeboyer MarionLochner ChristineMcCracken James TMedland Sarah EMortensen Preben BNeale Benjamin MNicolini HumbertoNordentoft MeretePato MichelePato CarlosPauls David LPiacentini JohnPittenger ChristopherPosthuma DanielleRamos-Quiroga Josep AntoniRasmussen Steven ARichter Margaret ARosenberg David RRuhrmann StephanSamuels Jack FSandin SvenSandor PaulSpalletta GianfrancoStein Dan JStewart S EvelynStorch Eric AStranger Barbara ETuriel MaurizioWerge ThomasAndreassen Ole ABørglum Anders DWalitza SusanneHveem KristianHansen Bjarne KRück ChristianMartin Nicholas GMilani LiliMors OleReichborn-Kjennerud TedRibasés MartaKvale GerdMataix-Cols DavidDomschke KatharinaGrünblatt EdnaWagner MichaelZwart John-AnkerBreen GeromeNestadt GeraldKaprio JaakkoArnold Paul DGrice Dorothy EKnowles James AAsk HelgaVerweij Karin JDavis Lea KSmit Dirk JCrowley James JScharf Jeremiah MStein Murray BGelernter JoelMathews Carol ADerks Eske MMattheisen Manuel - Epileptic encephalopathies are severe epilepsy syndromes characterized by early onset and progressive cerebral dysfunction. A nonsense variant in the DALR anticodon binding domain containing 3 (DALRD3) gene has been implicated in epileptic encephalopathy, but no other disease-associated variants in DALRD3 have been described. In human cells, the DALRD3 protein forms a complex with the METTL2 methyltransferase to generate the 3-methylcytosine (m3C) modification in specific arginine tRNAs. Here, we identify an individual with a homozygous missense variant in DALRD3 who displays developmental delay, cognitive deficiencies, and multifocal epilepsy. The missense variant substitutes an arginine residue to cysteine (R517C) within the DALR domain of the DALRD3 protein that is required for binding tRNAs. Cells derived from the individual homozygous for the DALRD3-R517C variant exhibit reduced levels of m3C modification in arginine tRNAs, indicating that the R517C variant impairs DALRD3 function. Notably, the DALRD3-R517C protein displays reduced association with METTL2 and loss of interaction with substrate tRNAs. Our results uncover another loss-of-function variant in DALRD3 linked to epileptic encephalopathy disorders. Importantly, these findings underscore DALRD3-dependent tRNA modification as a key contributor to proper brain development and function. - Source: PubMed
Publication date: 2024/10/31
Zhang KejiaLöhner KatharinaLemmink Henny HBoon MaartjeLentini Jenna Mde Silva NaduniFu Dragony - Vascular aging exacerbates diabetes-associated vascular damage, a major cause of microvascular and macrovascular complications. This study aimed to elucidate key genes and pathways underlying vascular aging in diabetes using integrated bioinformatics and machine learning approaches. Gene expression datasets related to vascular smooth muscle cell (VSMC) senescence and diabetic vascular aging were analyzed. Differential expression analysis identified 428 genes associated with VSMC senescence. Functional enrichment revealed their involvement in cellular senescence, ECM-receptor interaction, PI3K-Akt and AGE-RAGE signaling pathways. Further analysis of diabetic vascular aging datasets revealed 52 differentially expressed genes, enriched in AMPK signaling, AGE-RAGE signaling, cellular senescence, and VEGF signaling pathways. Machine learning algorithms, including LASSO regression and SVM-RFE, pinpointed six key genes: TFB1M, FOXRED2, LY75, DALRD3, PI4K2B, and NDOR1. Immune cell infiltration analysis demonstrated correlations between diabetic vascular aging, the identified key genes, and infiltration levels of plasma cells, M1 macrophages, CD8+ T cells, eosinophils, and regulatory T cells. In conclusion, this study identified six pivotal genes (TFB1M, FOXRED2, LY75, DALRD3, PI4K2B, and NDOR1) closely associated with diabetic vascular aging through integrative bioinformatics and machine learning approaches. These genes are linked to alterations in the immune microenvironment during diabetic vascular aging. This study provides a reference and basis for molecular mechanism research, biomarker mining, and diagnosis and treatment evaluation of diabetes-related vascular aging. - Source: PubMed
Publication date: 2024/05/27
Wang ShaWang XiaChen JingWang MinZhang Chi - Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including , , and multiple genes in the MHC region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and cortex, along with D1- and D2-type dopamine receptor-containing medium spiny neurons. OCD genetic risk was shared with 65 of 112 additional phenotypes, including all of the psychiatric disorders we examined. In particular, OCD shared genetic risk with anxiety, depression, anorexia nervosa, and Tourette syndrome, and was negatively associated with inflammatory bowel diseases, educational attainment, and body mass index. - Source: PubMed
Publication date: 2025/04/08
Strom Nora IGerring Zachary FGalimberti MarcoYu DongmeiHalvorsen Matthew WAbdellaoui AbdelRodriguez-Fontenla CristinaSealock Julia MBigdeli TimColeman Jonathan RMahjani BehrangThorp Jackson GBey KatharinaBurton Christie LLuykx Jurjen JZai GwynethAlemany SilviaAndre ChristineAskland Kathleen DBäckmann JuliaBanaj NerisaBarlassina CristinaNissen Judith BeckerBienvenu O JosephBlack DonaldBloch Michael HBørte SigridBosch RosaBreen MichaelBrennan Brian PBrentani HelenaBuxbaum Joseph DBybjerg-Grauholm JonasByrne Enda MCabana-Dominguez JuditCamarena BeatrizCamarena AdrianCappi CarolinaCarracedo AngelCasas MiguelCavallini Maria CristinaCiullo ValentinaCook Edwin HCrosby JesseCullen Bernadette ADe Schipper Elles JDelorme RichardDjurovic SrdjanElias Jason AEstivill XavierFalkenstein Martha JFundin Bengt TGarner LaurynGironda ChristinaGoes Fernando SGrados Marco AGrove JakobGuo WeiHaavik JanHagen KristenHarrington KellyHavdahl AlexandraHöffler Kira DHounie Ana GHucks DonaldHultman ChristinaJanecka MagdalenaJenike EricKarlsson Elinor KKelley KaraKlawohn JuliaKrasnow Janice EKrebs KristiLange ChristophLanzagorta NuriaLevey DanielLindblad-Toh KerstinMacciardi FabioMaher BrionMathes BrittanyMcArthur EvonneMcGregor NathanielMcLaughlin Nicole CMeier SandraMiguel Euripedes CMulhern MaureenNestadt Paul SNurmi Erika LO'Connell Kevin SOsiecki LisaOusdal Olga TheresePalviainen TeemuPedersen Nancy LPiras FabrizioPiras FedericaPotluri SriramyaRabionet RaquelRamirez AlfredoRauch ScottReichenberg AbrahamRiddle Mark ARipke StephanRosário Maria CSampaio Aline SSchiele Miriam ASkogholt Anne HeidiSloofman Laura GSmit JanSoler Artigas MaríaThomas Laurent FTifft EricVallada Homerovan Kirk NathanialVeenstra-VanderWeele JeremyVulink Nienke NWalker Christopher PWang YingWendland Jens RWinsvold Bendik SYao YinZhou Hang Agrawal ArpanaAlonso PinoBerberich GötzBucholz Kathleen KBulik Cynthia MCath DanielleDenys DamiaanEapen ValsammaEdenberg HowardFalkai PeterFernandez Thomas VFyer Abby JGaziano J MGeller Dan AGrabe Hans JGreenberg Benjamin DHanna Gregory LHickie Ian BHougaard David MKathmann NorbertKennedy JamesLai DongbingLandén MikaelLe Hellard StéphanieLeboyer MarionLochner ChristineMcCracken James TMedland Sarah EMortensen Preben BNeale Benjamin MNicolini HumbertoNordentoft MeretePato MichelePato CarlosPauls David LPiacentini JohnPittenger ChristopherPosthuma DanielleRamos-Quiroga Josep AntoniRasmussen Steven ARichter Margaret ARosenberg David RRuhrmann StephanSamuels Jack FSandin SvenSandor PaulSpalletta GianfrancoStein Dan JStewart S EvelynStorch Eric AStranger Barbara ETuriel MaurizioWerge ThomasAndreassen Ole ABørglum Anders DWalitza SusanneHveem KristianHansen Bjarne KRück ChristianMartin Nicholas GMilani LiliMors OleReichborn-Kjennerud TedRibasés MartaKvale GerdMataix-Cols DavidDomschke KatharinaGrünblatt EdnaWagner MichaelZwart John-AnkerBreen GeromeNestadt GeraldKaprio JaakkoArnold Paul DGrice Dorothy EKnowles James AAsk HelgaVerweij Karin JDavis Lea KSmit Dirk JCrowley James JScharf Jeremiah MStein Murray BGelernter JoelMathews Carol ADerks Eske MMattheisen Manuel