Ask about this productRelated genes to: ACOX3 Blocking Peptide
- Gene:
- ACOX3 NIH gene
- Name:
- acyl-CoA oxidase 3, pristanoyl
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 4p16.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-17
- Date modifiied:
- 2016-10-05
Related products to: ACOX3 Blocking Peptide
Related articles to: ACOX3 Blocking Peptide
- To investigate the mechanisms underlying benzo[a]pyrene-induced esophageal cancer (EC), and to screen and identify the key targets and biomarkers associated with benzo[a]pyrene-related EC. - Source: PubMed
Publication date: 2026/07/15
Lan XuyanHuang ZuqiangLin YukunSun XiaoyuGuo BinghanLi GenglinWang JintaoLin JinlanZhu LihuanGuo Tianxing - This study investigated the potential effects of Bellamya purificata polysaccharide (BPP) supplementation in feed on , aiming to elucidate its impact on immune function and the underlying regulatory mechanisms. A 60-day feeding trial was conducted to evaluate the effects of varying dietary BPP concentrations (0‱, 2‱, 4‱, 6‱, and 8‱) on growth performance, histopathology, immune function, and transcriptomic profiles of . Dietary BPP significantly increased the final body length and body weight of . Furthermore, BPP inclusion improved the histological damage of hepatopancreatic tissues, alleviated physiological stress, and enhanced antioxidant capacity, antibacterial activity, and anti-inflammatory function, as evidenced by alterations in relevant enzyme activities and gene expression levels. Transcriptomic analysis revealed 957 differentially expressed genes (DEGs), which were predominantly enriched in GO terms and KEGG pathways associated with BPP-mediated immune regulation, such as the PPAR signaling pathway, peroxisome, steroid hormone biosynthesis, and lysosome. In addition, 14 candidate genes were identified, including , , , and . Integrated analysis of GO, KEGG, and Short Time-Series Expression Miner (STEM) data supported the development of a mechanistic model illustrating how modulates immune function in response to BPP supplementation. RT-qPCR validation confirmed the accuracy and reliability of the high-throughput sequencing results. Collectively, these findings highlight the potential of BPP as a functional feed additive in aquaculture and provide novel insights into disease prevention strategies for the farming industry. - Source: PubMed
Publication date: 2026/07/22
Yuan ChangYang HuizanPan XianhuiLin YongZhou KangqiLin FengChen WenjianLi YusenHan YaoquanWei HuiWang CaiguangHuang LiangliangWang Dapeng - Acute kidney injury (AKI) is a life‑threatening condition with limited preventive medications. While the transcription factor Krüppel-like factor 4 (KLF4) is critical to AKI pathophysiology, its underlying molecular mechanisms remain incompletely understood. This study investigates KLF4 from a metabolic perspective and explores the renoprotective potential of doxycycline, an FDA-approved antibiotic. In murine models of ischemia‑reperfusion (IR)‑ and cisplatin (CDDP)‑induced AKI, doxycycline administered significantly attenuated kidney injury and protected renal tubular cells from glucose deprivation- and oxygen‑glucose deprivation-induced stress in vitro. Integrative transcriptomic and metabolomic profiling revealed that AKI progression involves profound metabolic dysfunction, characterized by the downregulation of peroxisomal Acyl-CoA oxidase 3 (ACOX3) and mitochondrial Isocitrate dehydrogenase 2 (IDH2). We identified KLF4 as a dual transcriptional repressor of ACOX3 and IDH2. Mechanistically, molecular docking, surface plasmon resonance, and co-immunoprecipitation assays demonstrated that doxycycline directly binds KLF4 and promotes its ubiquitin-mediated degradation via the E3 ligase FBXO32, which restores ACOX3/IDH2-mediated fatty acid oxidation and the TCA cycle, enhancing cellular resilience against ischemic crisis. These findings define a novel KLF4‑ACOX3/IDH2 metabolic axis and highlight doxycycline as a promising repositioning candidate for AKI prevention. - Source: PubMed
Publication date: 2026/07/24
Feng JiYao Zhi-ShengLi Yu-HongBai YanHu JunQi Cao-YanChen Zi-YiLiu Yue-TongXue KunZhou JingLu Guo-Dong - The aquaculture industry increasingly adopts palm oil (PO) as a sustainable alternative to fish oil (FO). However, whether this substitution induces adverse physiological responses under low-salinity stress remains poorly understood, especially for estuarine species. This study investigated the effects of long-term (10 weeks) dietary intake of FO and PO on growth, osmoregulation, mitochondrial function, lipid and energy metabolism, endoplasmic reticulum stress (ERS), and metabolomics in Scylla paramamosain under normal salinity (25‰, NS) and low salinity (6‰, LS). The results showed that crabs in the LS-PO group had significantly reduced percent weight gain compared to those in the LS-FO group. Additionally, LS-PO crabs demonstrated elevated hemolymph and posterior gill apoptosis, accompanied by severe gill structural damage and mitochondrial impairment in antennal glands. Osmoregulatory capacity was further compromised, as evidenced by decreased activities of Na⁺/K⁺-ATPase, V-ATPase, and CA compared to NS-FO and LS-FO groups. Mitochondrial dysfunction was indicated by reduced membrane potential, elevated ROS and MPTP, decreased SDH and ATP contents in the gills, and impaired mitochondrial respiratory chain complexes I-IV related genes expression in both posterior gills and hepatopancreas (nduf6, cox1, cyc1). PO further exacerbated the expression of ERS-related proteins (Grp78, P-Perk, Atf4, P-Ire1) in the hepatopancreas under low salinity. Hepatopancreatic lipid dysregulation was aggravated in LS-PO crabs, characterized by accumulated lipid droplets and downregulated expression of cpt1, hsl, acox1, and acox3. Notably, LS-PO crabs accumulated long-chain acylcarnitines and exhibited depletion of TCA intermediates (α-ketoglutarate), indicating severe suppression of mitochondrial β-oxidation. Correlation and interaction network analyses identified phosphorylcholine, glycerophosphocholine, na/k-atpase, hspa5, pelle, and relish as potential hub nodes. These findings indicate that, under the tested low-salinity conditions, dietary palm oil was less effective than fish oil in supporting osmoregulatory and metabolic homeostasis in Scylla paramamosain, highlighting the need to consider dietary lipid source when formulating feeds for low-salinity mud crab aquaculture. - Source: PubMed
Publication date: 2026/07/13
Xu TiantianLi XiaoyueDeng YaoXie ShichaoZhan WenhaoCui XishuaiJin MinZhou Qicun - Peroxisomal metabolism was long regarded as a housekeeping pathway with minimal involvement in cancer. Nonetheless, accumulating data demonstrate that peroxisomal lipid oxidation critically modulates genome stability and antitumor immunity. The acyl-CoA oxidase (ACOX) family-including ACOX1, ACOX2 and ACOX3-catalyzes the initial oxidative step of peroxisomal fatty acid β-oxidation, and governs lipid metabolism, redox homeostasis, as well as acyl-CoA-related post-translational modifications such as lysine crotonylation. Notably, ACOX2 has gained growing attention for its connections with DNA damage sensing, cGAS-STING activation and anticancer immunity. Dysregulated ACOX2 expression correlates with tumor progression, therapeutic response and clinical prognosis across various cancers, though direct functional evidence varies by tumor type. Mechanistically, ACOX2-related lipid metabolism maintains intracellular redox balance and stress adaptation, with its pathway-specific signaling still poorly defined. In clear cell renal cell carcinoma, ACOX2 binds MRE11 to destabilize the MRN complex, inducing cytosolic DNA buildup and cGAS-STING-mediated type I interferon signaling, while its universal role in other malignancies awaits validation. ACOX2 acts in a context-dependent fashion: it exerts tumor-suppressive effects in liver, prostate and lung cancers, yet facilitates metabolic adaptation and chemoresistance under therapeutic stress. This review summarizes ACOX2 as a key integrator of metabolism, immunity and genome integrity, and highlights its translational potential as a cancer biomarker and therapeutic target. - Source: PubMed
Publication date: 2026/05/23
Zheng MeiguiZhao BaihuiChen XiuyingZhao Ying