Ask about this productRelated genes to: TC2N Blocking Peptide
- Gene:
- TC2N NIH gene
- Name:
- tandem C2 domains, nuclear
- Previous symbol:
- C14orf47, MTAC2D1
- Synonyms:
- FLJ36557, Tac2-N, C2CD1
- Chromosome:
- 14q32.12
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-27
- Date modifiied:
- 2014-11-19
Related products to: TC2N Blocking Peptide
Related articles to: TC2N Blocking Peptide
- Temozolomide (TMZ) is used to treat glioblastoma cancer and it is essential to identify key genes and investigate the molecular mechanisms of glioblastoma cancer cells resistant to temozolomide. - Source: PubMed
Publication date: 2026/06/05
Alamholo MostafaTarinejad Alireza - Genome-wide studies in livestock have become essential tools for investigating genetic diversity, population structure, and adaptive evolution. By leveraging high-density single nucleotide polymorphism (SNP) arrays, researchers can identify genomic regions under selection and trace the demographic history of breeds. Among the most informative genomic features are Runs of Homozygosity (ROH), which reflect inbreeding levels and historical population dynamics, and Heterozygosity-Rich Regions (HRR), which may indicate loci under balancing selection and contribute to important functional traits. In this study, we investigated the ROH and HRR patterns in four different Mediterranean sheep breeds (Barbaresca-BAR, n = 48; Noticiana-NOT, n = 48; Valle del Belice-VDB, n = 142; and Sarda-SAR, n = 144) genotyped using the Illumina Ovine SNP600K array. The population structure analysis revealed a distinct separation among the four breeds, likely due to differences in breeding areas or management. Clear differences in ROH and HRR patterns were also observed. The endangered breeds (NOT and BAR) showed a higher mean number of ROH per individual (92.38 and 83.71, respectively) compared to SAR (60.38) and VDB (58.49). A total of 12 ROH islands, ranged from 0.13 to 2.83 Mb, have been detected. These genomic regions mapped genes associated with economically important traits, such as reproduction (ZDHHC21), milk (HERC3 and HERC6) and meat (ABCG2, PKD2, LAP3, NCAPG, and SPP1) production, and body size (LCORL). Regarding the HRR, the mean number of segments for individuals ranged from 4.65 (BAR) to 6.50 (VDB), and over 52% of these were shorter than 150 kb. The 16 HRR islands mapped genes related to reproduction (CAPSPERB and TC2N) and climate adaptation (VPS13B). Our results showed the usefulness of ROH and HRR for investigating genomic regions harboring genes associated with important traits that are consistent with the phenotypic characteristics of the investigated breeds, which present differences in both morphology and production traits and show excellent adaptability to the local environments. These findings may help in designing effective breeding or conservation programs for these sheep breeds. - Source: PubMed
Carta FedericaChessari GiorgioSardina Maria TeresaRiggio SilviaSenczuk GabrieleCesarani AlbertoCriscione AndreaMastrangelo Salvatore - Atherosclerosis is a chronic inflammatory disease involving mitophagy and immune dysregulation. Currently, there is no integrated diagnostic model for autophagy immune genes in mitochondria. This study aimed to identify potential diagnostic markers through integrated bioinformatics and experimental validation. - Source: PubMed
Publication date: 2025/10/03
Zhang JiaqiWang XitingChen XiahuanLiu Meilin - Tandem C2 domains, nuclear (TC2N) is a recently identified tumor-associated gene that has been confirmed to play important roles in various malignancies, including lung cancer, breast cancer, gastric cancer, glioma, and liver cancer. However, its biological functions and mechanisms in head and neck squamous cell carcinoma (HNSCC) remain unclear. In this study, we aimed to analyze the expression and methylation status of TC2N using public databases and preliminarily investigate the effects of TC2N on the malignant phenotypes of HNSCC cells and its potential mechanisms. - Source: PubMed
Publication date: 2025/07/27
Zhang QianZhou XiaogangHao XianglinSun QiZhang GangXu Shuai - Venous thromboembolisms (VTEs) are a leading cause of morbidity and mortality. Although many genetic risk factors have been identified, a substantial portion of the heritability remains unexplained. In this study, we employed a genome-wide association study (GWAS) for VTE across 9 international cohorts of the Global Biobank Meta-Analysis Initiative to address this question, along with in vivo functional validation. In this multipopulation GWAS (VTE cases, 27 987; controls, 1 035 290), 38 genome-wide significant loci were identified, 4 of which were potentially novel. For each autosomal locus, we performed gene prioritization using 7 independent, yet converging, lines of evidence. Through prioritization, we identified genes associated with VTE through GWAS and/or functional studies (eg, F5, F11, VWF, STAB2, PLCG2, TC2N), functionally validated those that did not have evidence other than GWAS (TC2N, TSPAN15), and discovered 1 not previously associated with coagulation (RASIP1). We evaluated the function of 6 prioritized genes with strong genetic evidence, including F7 as a positive control, using laser-mediated endothelial injury to induce thrombosis in zebrafish after CRISPR/Cas9 knockdown. From this assay, we have supportive evidence for the role of RASIP1 and TC2N in the modification of human VTE and suggestive evidence for STAB2 and TSPAN15. This study expands on the currently identified genomic architecture of VTE through biobank-based, multipopulation GWASs, in silico candidate gene predictions, and in vivo functional follow-up of candidate genes. - Source: PubMed
Wolford Brooke NZhao Queena YakunWu Kuan-Han HYu XingeRichter Catherine EBhatta LaxmiBrumpton Ben MDesch Karl CThibord FlorianKlarin DerekJohnson Andrew DTrégouët David-AlexandreDamrauer Scott MSmith Nicholas LLo Faro ValeriaTsuo KristinDaly Mark JNeale Benjamin MZhou WeiWiller Cristen JShavit Jordan ASurakka Ida