Ask about this productRelated genes to: TAPBP Blocking Peptide
- Gene:
- TAPBP NIH gene
- Name:
- TAP binding protein
- Previous symbol:
- -
- Synonyms:
- TAPA
- Chromosome:
- 6p21.32
- Locus Type:
- gene with protein product
- Date approved:
- 1997-12-17
- Date modifiied:
- 2019-04-23
- Gene:
- TAPBPL NIH gene
- Name:
- TAP binding protein like
- Previous symbol:
- -
- Synonyms:
- TAPBP-R, FLJ10143, TAPBPR
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-12
- Date modifiied:
- 2016-03-11
Related products to: TAPBP Blocking Peptide
Related articles to: TAPBP Blocking Peptide
- TAPASIN, a V-C1 (variable-constant) immunoglobulin superfamily (IgSF) molecule that links MHC class I molecules to the transporter associated with antigen processing (TAP) in the endoplasmic reticulum (ER) is encoded by the TAPBP gene, located near to the MHC at 6p21.3. A related gene was identified at chromosome position 12p13.3 between the CD27 and VAMP1 genes near a group of MHC-paralogous loci. The gene, which we have called TAPBP-R (R for related), also encodes a member of the IgSF, TAPASIN-R. Its putative product contains similar structural motifs to TAPASIN, with some marked differences, especially in the V domain, transmembrane and cytoplasmic regions. By using the mouse ortholog to screen tissue, we revealed that the TAPBP-R gene was broadly expressed. Sub-cellular localization showed that the bulk of TAPASIN-R is located within the ER but biotinylation experiments were consistent with some expression at thecell surface. TAPASIN-R lacks an obvious ER retention signal. The function of TAPASIN-R will be of interest in regards to the evolution of the immune system as well as antigen processing. - Source: PubMed
Teng Michelle SStephens RichardDu Pasquier LouisFreeman TomLindquist Jonathan ATrowsdale John