Ask about this productRelated genes to: ALDH18A1 Blocking Peptide
- Gene:
- ALDH18A1 NIH gene
- Name:
- aldehyde dehydrogenase 18 family member A1
- Previous symbol:
- GSAS, PYCS, SPG9
- Synonyms:
- P5CS
- Chromosome:
- 10q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-02
- Date modifiied:
- 2016-10-13
Related products to: ALDH18A1 Blocking Peptide
Related articles to: ALDH18A1 Blocking Peptide
- This study conducted a comprehensive comparison of the metabolomic and proteomic profiles of pigeon breast muscles from 12-month-old (M12) and 28-day-old (D28) birds to investigate the influence of age on meat quality. The M12 samples showed lower L*, a*, and b* values but higher ΔpH, shear force, cooking loss, hardness, cohesiveness, and gumminess compared to the D28 samples. Metabolomic analysis identified five down-regulated metabolites, L-histidine (fold change, FC = 0.216), L-arginine (FC = 0.560), 4-hydroxyproline (FC = 0.149), D-sedoheptulose 7-phosphate (FC = 0.465), and L-glutamic acid 5-phosphate (FC = 0.120), that were primarily involved in amino acid and related metabolic pathways, differentiating the two groups. Proteomic profiling revealed a reduced abundance of several proteins, importantly A306_00011918, A306_00011919, ENPP1, TKT, and ALDH18A1, which are involved in amino acid biosynthesis in M12. Integrative analysis of metabolomic and proteomic data highlighted amino acid biosynthesis, mediated by specific metabolites and proteins, as the major differentiating pathway between M12 and D28. In conclusion, these findings provide mechanistic insights into the molecular basis underlying age-dependent variations in pigeon meat quality, offering valuable guidance for poultry producers in determining the optimal slaughter age to achieve desirable meat characteristics. - Source: PubMed
Publication date: 2026/04/15
Wang YingMiao DongzhiChen JingZhang HaodongLi WanqingYang HaimingWang Zhiyue - The decline of the transcription factor NRF2 during aging contributes to impaired oxidative stress defense, yet the underlying mechanisms remain incompletely understood. Here we show that ALDH18A1 (P5CS) is downregulated in parallel with NRF2 in the airway epithelial cells of aged mouse lungs. Mechanistically, P5CS directly binds to Cullin3 and promotes its phosphorylation-a previously unrecognized post-translational modification of Cullin3-in a manner dependent on its kinase-like activity. This phosphorylation inhibits Cullin3 neddylation and disrupts its interaction with KEAP1, thereby impairing the ubiquitin ligase activity of the Cullin3-KEAP1 complex and leading to NRF2 stabilization. A kinase-dead mutant (T299I) or pharmacological inhibition of P5CS kinase-like activity abolishes this regulatory effect. Our findings identify Cullin3 phosphorylation as a novel regulatory mechanism controlling NRF2 stability and provide a molecular explanation for the age-related decline of NRF2 downstream of P5CS downregulation. - Source: PubMed
Publication date: 2026/04/14
Chang YunhaoChen QiaoWan XinlongChen BoSun ZhigangWu JianqingHuang Shuhong - Clear cell renal cell carcinoma (ccRCC) is the most prevalent subtype of renal cancer and represents high heterogeneity and poor prognosis. Current evidence highlights that the senescence program, particularly through SASP, can simultaneously impose tumor-suppressive barriers and, under specific conditions, support malignant progression. Nevertheless, the comprehensive characterization and clinical significance of cellular senescence in ccRCC have yet to be fully elucidated. - Source: PubMed
Publication date: 2026/03/02
Wang JiaweiKong WeiyuShao WenchuanYu ZijieLiu HeqianGao ZehongLiu YingqingZhao YutingTao LingsongZhang MingcongLiang Chaozhao - Gastric cancer (GC) remains one of the most lethal malignancies worldwide due to its substantial heterogeneity, necessitating improved therapeutic strategies and prognostic tools. Recent studies have implicated dysregulated arginine metabolism in GC pathogenesis; however, its metabolic characteristics and clinical prognostic value are not fully understood. - Source: PubMed
Publication date: 2026/01/07
Shao YongfuYu XuanYan JianingDong Haotian
- Source: PubMed