Ask about this productRelated genes to: OPA3 Blocking Peptide
- Gene:
- OPA3 NIH gene
- Name:
- outer mitochondrial membrane lipid metabolism regulator OPA3
- Previous symbol:
- -
- Synonyms:
- FLJ22187, MGA3
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1999-03-12
- Date modifiied:
- 2019-04-08
Related products to: OPA3 Blocking Peptide
Related articles to: OPA3 Blocking Peptide
- Autosomal dominant optic atrophy (DOA) is an inherited optic neuropathy characterized by progressive bilateral vision loss, cecocentral visual field (VF) defects, and retinal ganglion cell degeneration. Most cases are associated with mutations, while -related DOA is rare and typically involves both eyes. To date, unilateral disease has not been reported. - Source: PubMed
Publication date: 2025/12/11
Ware Matthaeus AntonyLi Haoran CharlesMicieli Jonathan - Acute and long-term mental health disorders correlate with coronavirus disease 2019 (COVID-19). The underlying mechanisms responsible for the coexistence of COVID-19 and depression remain unclear, and more research is needed to find hub genes and effective therapies. The main objective of this study was to evaluate gene-expression profiles and, identify key genes, and discovery potential therapeutic agents for co-occurrence in COVID-19 and major depressive disorder (MDD). - Source: PubMed
Publication date: 2025/08/22
Chen ShaojunLuo YiyuanZhang Lihua - The aim of this study was to evaluate the short- and long-term repeatability of a spectrophotometer and three mobile phone color applications (MCAs) on the iPhone Operating System (iOS) platform for color differences of single-shade and multi-shade resin materials of different thicknesses. - Source: PubMed
Publication date: 2025/07/16
Olgar İbrahim ElginYağcı ÖzhanFidan Muhammet - Olive cultivation in Rajasthan, India, has recently gained significant attention. To understand the genetic diversity among the cultivars of olive (Olea europaea L.) grown in Rajasthan, India, a cumulative approach using Random Amplified Polymorphic DNA (RAPD) markers was employed. This approach was based on morphological, biochemical, nutritional, and associated markers like antimicrobial and antioxidant potential linked to the functional activity of the primary and secondary metabolites. Eight primers (OPA-1, OPA2, OPA3, OPA4; OPB1, OPB2, OPB3, and OPB4) were used to differentiate the seven cultivars of olive. The results indicated 51 reproducible bands showing 45 polymorphism bands (88.23%). The disparity among the cultivars was evident, encompassing their morphological characteristics, biochemical features (protein, fat, carbohydrate, total phenolics, flavonoid, DPPH IC50, radical scavenging activity), and their inhibitory responses against different microorganisms. The genetic analysis using an unweighted pair group method with arithmetic averaging revealed diversity, and the dendrogram formed four distinct groups. These results demonstrate the molecular variance allowing the genetic diversity between the seven exotic cultivars imported from Israel. Considering the aforementioned phylogenetic study, this innovative method can potentially aid in understanding the future crop breeding initiatives in India and the improvement of olives. - Source: PubMed
Publication date: 2025/05/28
Sisodiya SmitaDebnath MousumiJain DevendraShekhawat Surinder Singh - Colorectal cancer (CRC) is an extremely harmful malignant tumor. Optic atrophy 3 (OPA3) is highly expressed in multiple tumors, but its action in CRC is still unknown. This research aims to explore the role of OPA3 and its related molecular mechanisms for CRC. Firstly, we overexpressed and knocked down OPA3 to examine its effect on CRC cell (HT29 cell) growth. CRC cell viability, migration, invasion, and levels of proliferation markers and cell cycle-associated proteins were measured. Then, we treated cells with carbonyl cyanide m-chlorophenyl hydrazone (CCCP) to explore mitochondrial dysfunction and mtDNA stress in HT29 cells. Next, we overexpressed cGAS and STING to examine their correlation with OPA3. The results showed that OPA3 overexpression enhanced CRC cell viability, migration, invasion, and the levels of PCNA, Cyclin A2, and Cyclin B1. Knockdown of OPA3 had the opposite effects. Moreover, OPA3 knockdown facilitated mitochondrial dysfunction and mtDNA stress in CRC cells. OPA3 overexpression also inhibited CCCP-induced mitochondrial stress disorder. Additionally, OPA3 knockdown elevated the protein levels of p-STING and cGAS and the mRNA level of STING target genes. Furthermore, overexpression of either cGAS or STING partially alleviated the enhancement of HT29 cell proliferation, migration, and invasion mediated by OPA3 overexpression. In conclusion, OPA3 promotes CRC progression via inhibiting the cGAS-STING pathway, which is mediated by mtDNA stress. OPA3 may be a new potential target for CRC. - Source: PubMed
Publication date: 2024/12/26
Yin YuqiangMa ZhenxinYuan SiwenXu KangfengWang Xiaofeng