Ask about this productRelated genes to: PKLR Blocking Peptide
- Gene:
- PKLR NIH gene
- Name:
- pyruvate kinase L/R
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q22
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: PKLR Blocking Peptide
Related articles to: PKLR Blocking Peptide
- Hereditary spherocytosis (HS) is a genetically and clinically diverse red cell membrane disorder, with limited clinical and molecular data on pediatric patients from India. - Source: PubMed
Publication date: 2026/04/23
Chakraborty AnkitaKalra ManasSachdeva AnupamKotwal JyotiLanger SabinaSaraf AmritaRana PallaviDahiya SurbhiArya VandanaAggarwal SatishPrasad Alpana - Pyruvate kinase deficiency (PKD) is a rare cause of hereditary non-spherocytic hemolytic anemia. This study reports the clinical and molecular characterization of three pediatric PKD cases, focusing on two novel PKLR variants. - Source: PubMed
Publication date: 2026/04/28
Xiang HuaxiaWen YuxiuYang MengxinJiang JialiLi YupingHe ChangjinLin ZhihaoWei Hongying - Persistent pulmonary hypertension of newborn (PPHN) occurs due to the impairment in the expected fall in pulmonary vascular resistance during the fetal to neonatal circulatory transition, with a prevalence of 1.9 per 1,000 live births and a significant mortality rate of 4-33%. We aimed to systematically review the genetic variants associated with PPHN in term and late preterm infants without a known genetic syndrome. - Source: PubMed
Publication date: 2026/03/13
Mani SrinivasanBerger Seth I - In order to explore the main regulatory genes and related pathways of growth traits, transcriptome sequencing was performed on the hypothalamus, pituitary, and liver tissues of 12-month-old greater amberjack () with different growth rates. In total, 504 (118 up- and 386 down-regulated), 556 (283 up- and 273 down-regulated), and 699 (224 up- and 475 down-regulated) differentially expressed genes (DEGs) were identified in the hypothalamus, pituitary, and liver tissues, respectively. GO and KEGG pathway analyses revealed significant differences in the expression of several genes involved in growth, metabolism, and immune-related pathways. The mRNA expression levels of genes related to growth (, , ), cell proliferation (, , , , and ), and lipid metabolism (, , , , and ) were up-regulated in the fast-growing (FG) group, while the and were down-regulated. Conversely, genes associated with glycolysis (, , ), citrate cycle (, ), and immune-related pathways (, , , , , , and ) were up-regulated in the slow-growing (SG) group. These findings indicate that the FG exhibited greater lipid metabolism capacity and cell proliferation ability, while the SG expended additional energy to cope with environmental stress, with hindered growth during immune response. This study enhances our understanding of the genetic mechanisms underlying differences in growth rates and provides essential gene resources for future growth-related molecular breeding programs in greater amberjack. - Source: PubMed
Publication date: 2026/02/06
Ru XiaoyingLi XiaojingHuang YangChen PeipeiDeng QiuxiaLi HangZhou QibingLin HaoyiHao RuijuanLiao YongguanWu JinhuiZhao YanfeiZhu Chunhua - The flavor of chicken meat is a major determinant of consumer preference, yet its genetic basis remains poorly understood. Here, we integrated volatile metabolomics, RNA-seq, proteomics, and phosphoproteomics of breast muscle from Qingyuan partridge chicken (QPC) and Cobb broiler (CB). 318 volatile compounds were detected, among which eight (2-pentylfuran, isophorone, 2-undecanone, benzaldehyde, pentanal, 2-heptanone, ethyl acrylate, and 1-octanol) were key differentiators between breeds. Multi-omics analysis revealed carbohydrate metabolism genes (GPI, PGM1, FBP2, LDHA, PGAM1, PGK2, LDHB, PFKM, PKLR, ALDOA, LOC107050559) significantly correlated with key volatile compounds, with GPI and LDHA correlated with all key compounds across expression and phosphorylation levels. Importantly, we identified a PPP1R3A-PPP1CA-GYS1 phosphorylation axis that regulates glycogen metabolism and thereby influences precursor content for Maillard reactions. These findings suggest that carbohydrate metabolism and its phosphorylation cascades may contribute to meat flavor, providing a molecular basis for genetic improvement in poultry. - Source: PubMed
Publication date: 2026/01/20
Yang XinChai XuewenGong JishangLuo WenXu Jiguo