Ask about this productRelated genes to: HSDL1 Blocking Peptide
- Gene:
- HSDL1 NIH gene
- Name:
- hydroxysteroid dehydrogenase like 1
- Previous symbol:
- -
- Synonyms:
- SDR12C3
- Chromosome:
- 16q24.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-12-15
- Date modifiied:
- 2016-10-05
Related products to: HSDL1 Blocking Peptide
Related articles to: HSDL1 Blocking Peptide
- A comprehensive analysis of the transcriptomic landscape in early-stage LUAD (stages 1 and 2) can identify robust survival and staging predictors. Using a systems-biology approach with TCGA LUAD transcriptomic data, we identified 18 co-expression modules, 11 correlated with staging and 7 with survival. Five survival- and staging-associated (SAS) modules (M1, M3, M6, M9, and M16) distinguished patients with differing survival curves based on module eigengene expression. Anti-correlated SAS-modules (M3 and M6) exhibited the strongest associations with OS and staging. Key differentially-expressed hub genes from M3 and M6 were nominated as prognostic markers through iterative combinatorial ROC analysis. Survival prediction was refined by testing equal-weight gene ratios with opposing correlations to survival, revealing additive or synergistic predictive value. The top-performing ratio, ATP6V0E1 + SVBP + HSDL1 + UBTD1/GNPNAT1 + XRCC2 + TFAP2A + PPP1R13L, achieved an average AUC of 75.5% across three timepoints (12 months, 18 months, and 3 years). Comparison with three established LUAD prognostic signatures (Shedden, Soltis, and Song) within the TCGA network showed that our 8-gene signature had comparable or superior predictive power while maintaining concordance with existing signatures, some of which contain an order of magnitude more transcripts. Our findings suggest that novel gene signature holds promise for refining early-stage LUAD prognostic modeling and informing treatment strategies. - Source: PubMed
Publication date: 2025/10/06
Young Corey DCarey Kaylin MDill Courtney DNunez Sha'Kayla KGriffen Ti'ara LDammer Eric BLillard James W - The Percidae family comprises many fish species of major importance for aquaculture and fisheries. Based on three new chromosome-scale assemblies in Perca fluviatilis, Perca schrenkii, and Sander vitreus along with additional percid fish reference genomes, we provide an evolutionary and comparative genomic analysis of their sex-determination systems. - Source: PubMed
Publication date: 2024/06/26
Kuhl HeinerEuclide Peter TKlopp ChristopheCabau CédricZahm MargotLopez-Roques CélineIampietro CaroleKuchly ClaireDonnadieu CécileFeron RomainParrinello HuguesPoncet CharlesJaffrelo LydiaConfolent CaroleWen MingHerpin AmauryJouanno ElodieBestin AnastasiaHaffray PierrickMorvezen Romainde Almeida Taina RochaLecocq ThomasSchaerlinger BéréniceChardard DominiqueŻarski DanielLarson Wesley APostlethwait John HTimirkhanov SerikKloas WernerWuertz SvenStöck MatthiasGuiguen Yann - The Percidae family comprises many fish species of major importance for aquaculture and fisheries. Based on three new chromosome-scale assemblies in , and along with additional percid fish reference genomes, we provide an evolutionary and comparative genomic analysis of their sex-determination systems. We explored the fate of a duplicated anti-Mullerian hormone receptor type-2 gene (), previously suggested to be the master sex determining (MSD) gene in . Phylogenetically related and structurally similar a duplications () were found in and , potentially dating this duplication event to their last common ancestor around 19-27 Mya. In and , this duplicate has been lost while it was subject to amplification in . Analyses of the locus in suggest that this duplication could be also male-specific as it is in . In , a relatively small (100 kb) non-recombinant sex-determining region (SDR) was characterized on chromosome-18 using population-genomics approaches. This SDR is characterized by many male-specific single-nucleotide variants (SNVs) and no large duplication/insertion event, suggesting that has a male heterogametic sex determination system (XX/XY), generated by allelic diversification. This SDR contains six annotated genes, including three (, , ) with higher expression in testis than ovary. Together, our results provide a new example of the highly dynamic sex chromosome turnover in teleosts and provide new genomic resources for Percidae, including sex-genotyping tools for all three known species. - Source: PubMed
Publication date: 2023/11/16
Kuhl HeinerEuclide Peter TKlopp ChristopheCabau CedricZahm MargotRoques CélineIampietro CaroleKuchly ClaireDonnadieu CécileFeron RomainParrinello HuguesPoncet CharlesJaffrelo LydiaConfolent CaroleWen MingHerpin AmauryJouanno ElodieBestin AnastasiaHaffray PierrickMorvezen Romainde Almeida Taina RochaLecocq ThomasSchaerlinger BéréniceChardard DominiqueŻarski DanielLarson WesPostlethwait John HTimirkhanov SerikKloas WernerWuertz SvenStöck MatthiasGuiguen Yann - The eyestalk of crustaceans, such as Macrobrachium nipponense, contains many neurosecretory hormones affecting the process of reproduction, molting, metabolism of glucose, and other functions. In this study, important metabolic pathways and candidate genes involved in male sexual development were selected from M. nipponense. The methodology involved performing long-read and next generation transcriptome sequencing of genes from the androgenic gland after eyestalk ablation. qPCR analysis revealed that the mRNA expression of Mn-IAG was significantly increased after ablation of both the single-side (SS) and double-side (DS) eyestalk, compared with the control group (CG). The long-read transcriptome generated 49,840 non-redundant transcripts. A total of 1319, 2092 and 4351 differentially expressed genes (DEGs) were identified between CG versus SS, SS versus DS and CG versus DS, respectively. These data indicated that ablation of the double-sided eyestalk played stronger regulatory roles than the single-side ablation on male sexual development in M. nipponense. This was consistent with the qPCR analysis. Cell Cycle, Cellular Senescence, Oxidative Phosphorylation, Glycolysis/Gluconeogenesis and Steroid Hormone Biosynthesis were the primary enriched metabolic pathways in all three comparisons, and the important genes from these metabolic pathways were also selected. qPCR permitted secondary confirmation of ten DEGs identified through RNA-seq. RNAi-mediated silencing analyses of Hydroxysteroid dehydrogenase like 1 (HSDL1) revealed that HSDL1 has a positive regulatory effect on testes development. This study provides valuable insight into male sexual development in M. nipponense, including metabolic pathways and genes, paving the way for advanced studies on male sexual development in this species and in other crustaceans. - Source: PubMed
Publication date: 2021/10/06
Jin ShuboFu YinHu YuningFu HongtuoJiang SufeiXiong YiweiQiao HuiZhang WenyiGong YongshengWu Yan - Ocean acidification (OA), which refers to a gradual decrease in seawater pH due to the absorption of atmospheric carbon dioxide, profoundly affects the growth, development and survival of bivalves. Relatively limited studies have assessed the resilience of bivalve to OA. In the present study, Patinopecten yessoensis, an economically and ecologically significant species, were exposed to low pH (pH = 7.5) for 4 weeks. Forty-seven scallops that died in the first week were considered pH-sensitive population, and 20 that were alive at the end of the experiment were considered pH-tolerant population. A genome-wide association study was conducted to identify the genomic loci associated the resilience of P. yessoensis to OA. Twenty-one single nucleotide polymorphisms were significantly associated with resilience, which were distributed in 11 linkage groups. Within the linkage disequilibrium block region (± 300 kb) surrounding the 21 SNPs, 193 candidate genes were successfully identified. Particularly, five associated SNPs were directly located on five genes, including SP24, CFDH, 5HTR3, HSDL1 and ZFP346. The GO enrichment and KEGG pathway analyses showed that the molecular response of P. yessoensis to OA mainly involved neural signal transmission, energy metabolism and redox reaction. Candidate genes were expressed during larval development and in adult tissues. Furthermore, the expression of 30 candidate genes changed significantly under low pH stress in the mantle. Our results reveal certain SNPs and candidate genes that could elucidate the different responses of P. yessoensis to OA. The genetic variations indicated molecular resilience in P. yessoensis populations, which may enable adaptation to future acidification stress. - Source: PubMed
Publication date: 2021/09/12
Yang ZujingSun FanhuaLiao HuanZhang ZhengruiDou ZhengXing QiangHu JingjieHuang XiaotingBao Zhenmin