Ask about this productRelated genes to: HPRT1 Blocking Peptide
- Gene:
- HPRT1 NIH gene
- Name:
- hypoxanthine phosphoribosyltransferase 1
- Previous symbol:
- HPRT
- Synonyms:
- HGPRT
- Chromosome:
- Xq26.2-q26.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2018-02-13
Related products to: HPRT1 Blocking Peptide
Related articles to: HPRT1 Blocking Peptide
- To describe clinical, radiological, biochemical, and genetic features in a multigenerational family with HPRT1-related gout and highlight intrafamilial phenotypic variation. - Source: PubMed
Publication date: 2026/07/28
Bilici ReyhanDuymus FahrettinAtas Abdullah EnesCelikdelen Selma Özlem - : Recurrent pregnancy loss (RPL) is frequently linked to antiphospholipid antibodies, yet many affected women are seronegative for the classical (Sydney) criteria antibodies. In a previously characterized cohort, an extended antiphospholipid antibody panel was positive in 79% of women with RPL, with the strongest associations for antibodies against prothrombin, annexin V and β-glycoprotein I. Whether this association reflects molecular endometrial dysfunction was unclear. : To examine endometrial expression of ten decidualization- and inflammation-related genes in women with RPL, stratified by APL status, focusing on the dominant antibody specificity: anti-β-glycoprotein I. : Thirty-nine women with RPL (≥2 losses), a subsample of a published 100-patient cohort, underwent mid-luteal Pipelle endometrial biopsy followed by RT-PCR for , , , , , , , , and . Antibodies were measured by antiphospholipid 10 Dot line immunoblot (Generic Assays, Germany). The analysis used Mann-Whitney U, Fisher's exact test, Benjamini-Hochberg correction and ROC analysis. : Antibody prevalence in the subsample matched the parent cohort (Pearson r = 0.999). Of ten transcripts, only showed a nominally significant reduction in APL+ women (median ΔCt -2.04 vs. -1.30; = 0.037; rank-biserial r = -0.47); this signal did not survive Benjamini-Hochberg correction (q = 0.372). The signal was specific to anti-βGPI ( = 0.064; AUC 0.700), not to annexin V or prothrombin. A cut-off of ΔCt ≤ -1.60 identified APL+ status with 73% sensitivity, 78% specificity and OR 9.62 (95% CI 1.64-56.4; = 0.015). clustered with (ρ = 0.65) and (ρ = 0.70). : Anti-β-glycoprotein I antibodies, the dominant APL specificity in RPL, are associated with reduced endometrial expression. This exploratory data outline a candidate molecular pathway linking extended antiphospholipid serology to impaired endometrial receptivity. - Source: PubMed
Publication date: 2026/07/12
Khalmirzaeva MadinaOmarova GulzhakhanKurmanova AlmagulKurmanova GaukharAnartayeva GainiZhankina ZhamilyaTulesheva AidanaVeliyeva AinuraJarikova BotakuzDzheksembekova Alfiya - Unhealthy lifestyles promote brain aging, but their mechanisms remain unclear. The liver-brain axis acts as a key mediator of brain dysfunction and warrants investigation in lifestyle-induced brain aging. - Source: PubMed
Publication date: 2026/07/15
Tu HuifangHou YunlongCui WenwenWang XiaoqingChen MengShi MinKang TianyuJiang YibingWu QiulanLi WenyanCai JingqiWang LuWang ZixuanHou BinChang LipingZhao ShaohuaJia ZhenhuaLi Mengnan - Head and neck squamous cell carcinoma (HNSCC) is a highly heterogeneous malignancy with poor prognosis, accompanied by metabolic reprogramming and tumor microenvironment (TME) disorders. Lactate metabolism is critical for tumor progression and immune escape, but its regulatory mechanism and clinical value in HNSCC remain unclear. We integrated single-cell and bulk RNA-sequencing data to identify lactate metabolism-related genes (LMGs). Using three machine learning algorithms, we selected six core LMGs and constructed a prognostic signature, which was validated in GSE41613 and GSE65858. Stem-like malignant cells showed the highest lactate metabolism activity among six epithelial subtypes. High-risk patients had shorter overall survival, with lower CD8 + T cell infiltration and higher M0 macrophages. Core genes were enriched in metabolic regulation and DNA replication. Compared with the high-risk group, low-risk patients exhibited higher sensitivity to chemotherapy and immunotherapy, and may benefit from BCL‑2/BCL‑XL inhibitors. Among the core genes, HPRT1 represents the most promising biomarker, whose expression is positively correlated with lactate production. This lactate‑related signature serves as a promising prognostic biomarker and therapeutic target, revealing metabolic-immune regulatory mechanisms in HNSCC. - Source: PubMed
Publication date: 2026/07/12
Wang YuqingShi TaoYu LishengZhao Yixin - The reliability and accuracy of relative quantification of transcripts through quantitative real-time PCR (qPCR) is dependent on the use of stable reference genes for normalization. However, the expression stability of various reference genes may differ across the tissues and patho-physiological conditions. The present study investigated the stability of multiple candidate reference genes in Japanese quail (Coturnix japonica) embryos, subjected to embryonic thermal conditioning (ETC). Fertilized quail eggs (n = 200) were incubated under standard conditions and heat exposure (ETC) of incubated eggs was undertaken at 39.5 °C for 10 h daily in the embryonic days 6-8 and 12-14, maintaining constant humidity (55%). Four embryos were randomly selected from each group for experimentation. The expression levels of eight candidate reference genes i.e., 18 S rRNA, β-ACTIN, 28 S rRNA, HPRT1, GAPDH, PGK1, RPS8, and TBP were assessed across four tissues (liver, intestine, brain, and heart) under ETC. Gene expression stability was assessed using five different algorithms: geNorm, NormFinder, BestKeeper, Delta Ct, and RefFinder (Comprehensive gene stability). Variations in gene stability were evident across different tissues and algorithms. The HPRT1, GAPDH and RPS8 emerged as the most stable reference genes for qPCR analyses in liver tissue, making them suitable internal controls. Similarly, PGK1, RPS8, and HPRT1 genes exhibited higher expression stability in intestine. On the other hand, TBP and HPRT1 were identified as the most reliable reference genes for normalization in heart tissue, whereas HPRT1 and GAPDH were found to be the most reliable reference genes in brain tissue. On considering all tissues combined (liver, intestine, brain, and heart), TBP and RPS8 emerged as the most suitable gene set for normalization. This present study provides crucial insights into selecting appropriate reference genes for relative expression quantification studies in quail embryos under heat treatment (ETC), thereby improving the reliability and accuracy of qPCR data in avian developmental and stress physiology research. - Source: PubMed
Publication date: 2026/07/01
Ansari Mohd MatinMartina KKolluri GauthamTyagi Jagbir SinghRokade JaydipBhutekar PrashantNaim AdnanGangwar MunishAhmad Sheikh Firdous