Ask about this productRelated genes to: RNF165 Blocking Peptide
- Gene:
- RNF165 NIH gene
- Name:
- ring finger protein 165
- Previous symbol:
- -
- Synonyms:
- ARKL2, RNF111L2, Ark2C
- Chromosome:
- 18q21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-07
- Date modifiied:
- 2018-05-11
Related products to: RNF165 Blocking Peptide
Related articles to: RNF165 Blocking Peptide
- Advances in American mink () genomics have identified candidate genes linked to disease resistance, including , which is involved in immune response and virus-host interactions. Objectives: This study aimed to characterize genetic variation within the (Ring Finger Protein 165) gene in farmed and wild mink to identify polymorphisms potentially associated with resistance to Aleutian mink disease virus (AMDV). Two groups of mink were analyzed: farmed animals from Latvia ( = 50) and wild animals ( = 20) from Poland. The presence of viral DNA was verified by PCR amplification targeting the and viral protein genes. To assess polymorphism within , primers spanning eight exons were designed, optimized, and applied in PCR amplification. PCR products were sequenced and subjected to bioinformatic analysis. Two single nucleotide polymorphisms were identified: a synonymous substitution at c.G141A and a missense mutation c.G596A (p.R199K). Both variants were present in farmed and wild populations; however, the G allele at position c.141 was nearly twice as frequent in farmed mink compared to wild mink ( < 0.05). In silico functional prediction (SNAP2) indicated that the p.R199K mutation may moderately affect RNF165 protein function. Owing to its high conservation and role in immune regulation, may serve as a promising candidate gene for molecular selection in breeding programs aimed at enhancing resistance to Aleutian mink disease (AMD). - Source: PubMed
Publication date: 2025/11/28
Mazurkiewicz IlonaJakubczak AndrzejKowalczyk Marek - In the chicken industry, sex determination significantly affects production efficiency and raises ethical concerns in poultry farming. As a key economic species, maximizing the advantages of each sex is vital in modern intensive breeding. Therefore, understanding the mechanisms of sex determination and regulation is critical to advancing the poultry industry. Transcriptome analysis of 3.5-day-old White Leghorn chicken embryonic genital ridges ( = 30, 15 males and 15 females) was performed using sex-pooled samples (five embryos/replicate, three replicates/sex). Sequencing generated 39.6 GB of high-quality reads for inter-sex comparative analysis, revealing 283 significantly differentially expressed genes (DEGs). The DEGs were primarily enriched in pathways such as ribosome biogenesis, glycan biosynthesis and metabolism, and TGF-β signaling, which are potential candidate pathways for the differentiation of chicken embryonic gonads. Key DEGs (including , , , , , , , , , and ) were validated by RT-qPCR, confirming the transcriptome sequencing results. Among the DEGs, we predict binding sites for and within the gene promoter and suggest that these factors may serve as potential upstream activators for the expression of , and they may initiate high expression in the subsequent stages of male embryos and regulate testicular development. In conclusion, this study investigated DEGs in the gonads of male and female chicken embryos after 3.5 days of incubation and found that and may serve as potential upstream activators for the expression of , which is involved in the early determination of chicken sex. - Source: PubMed
Publication date: 2025/10/01
Liu RuijiaMiao HuanhuanZhang BoZhang Hao - Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease frequently leading to heart failure. Although sarcomeric gene mutations are known, they only account for a subset of cases. The role of immune dysregulation in HCM progression has gained increasing attention, necessitating the exploration of immune-related biomarkers and therapeutic targets. This study integrates Mendelian randomization (MR), transcriptomics, machine learning, and experimental validation to investigate the immune mechanisms underlying HCM. - Source: PubMed
Publication date: 2025/09/26
Liang QingzhuWang JinNong QingxiaoTao ShouwenFang Dalang - Chemoresistance is the primary contributor to distant metastasis in the context of neoadjuvant chemoradiotherapy (nCRT) for rectal cancer. However, the underlying mechanisms remain elusive. - Source: PubMed
Li Gan-BinShi Wei-KunZhang XiaoQiu Xiao-YuanLin Guo-Le - E3 ubiquitin ligases play critical roles in regulating cellular signaling pathways by inducing ubiquitylation of key components. RNF111/Arkadia is a RING E3 ubiquitin ligase that activates TGF-β signaling by inducing ubiquitylation and proteasomal degradation of the transcriptional repressor SKIL/SnoN. In this study, we have sought to identify novel regulators of the E3 ubiquitin ligase activity of RNF111 by searching for proteins that specifically interacts with its RING domain. - Source: PubMed
Publication date: 2023/04/07
Amhaz SadekBoëda BatisteChouchène MounaColasse SabrinaDingli FlorentLoew DamarysHenri JulienPrunier CélineLevy Laurence