RNF179 Blocking Peptide
- Known as:
- RNF179 Blocking Peptide
- Catalog number:
- 33r-8781
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- RNF179 Blocking Peptide
Related genes to: RNF179 Blocking Peptide
- Gene:
- MARCH9 NIH gene
- Name:
- membrane associated ring-CH-type finger 9
- Previous symbol:
- -
- Synonyms:
- RNF179, FLJ36578
- Chromosome:
- 12q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-26
- Date modifiied:
- 2015-11-26
Related products to: RNF179 Blocking Peptide
Related articles to: RNF179 Blocking Peptide
- Mitochondrial dysfunction affects the development of ovarian cancer (OC). ETV4 is involved in mitochondrial fusion. The regulatory pathways of ETV4 in OC cells have not been further investigated. In this study, we aimed to explore the effects of ETV4 on OC development and analyze the downstream regulatory pathways of ETV4. - Source: PubMed
Publication date: 2025/10/20
Wang YingWang ZhanChen JuanCai LiLuo XiaWu Nayiyuan - NLRP3, a member of the NOD-like receptor family, mediates pyroptosis via inflammasome activation, contributing significantly to myocardial ischemia-reperfusion (MI/R) injury. However, the molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms underlying NLRP3 inflammasome activation and its role in pyroptotic myocyte death following MI/R injury, with a particular focus on the effects of MARCH9, an E3 ubiquitin ligase that encodes a RING finger domain. In our in vivo experiments, we established an MI/R injury model by ligating the anterior descending branch of the coronary artery in mice. Cardiac tissues were analyzed using various methods, including proteomic analysis, TTC and Evan's blue dual-dye staining, immunohistochemical staining (F4/80, CD11b and Ly6G), and immunofluorescent staining (GSDMD-N). Western blotting was also performed to assess the expression of key pyroptosis-related proteins, such as MARCH9, NLRP3, caspase-1, GSDMD-N, and AIM2. In vitro studies in H9C2 and HEK293 cell lines involved western blotting, co-immunoprecipitation, and immunofluorescent staining to examine protein interactions and functional domains. Our findings reveal that MARCH9 plays a key regulatory role in NLRP3 inflammasome activation and pyroptosis during MI/R injury. MARCH9 was identified as an E3 ubiquitin ligase that interacts with NLRP3, promoting its K48-linked polyubiquitination and subsequent proteasomal degradation. This process inhibits NLRP3 activation, thereby mitigating pyroptosis and reducing myocardial injury. In conclusion, MARCH9 suppresses pyroptosis by modulating NLRP3 ubiquitination in response to MI/R injury, highlighting its potential as a novel cardioprotective target for therapeutic intervention. - Source: PubMed
Publication date: 2025/10/07
Lu HongquanMa GangDing CongWang PingRuan QiuyueZeng YunMa LingkunLu MinLi YilinSun Wenjing - To overcome the challenges in laparoscopic bariatric surgery, robotic platforms are an attractive option. One such robotic platform is the BORNS Simphoni Robotic System, which has been evaluated for clinical use in this study. - Source: PubMed
Publication date: 2025/06/09
Bindal VivekPandey DhananjayGupta ShaileshSaxena RajeshTeichmann Alexander Tobias - Increased expression of leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is associated with immune evasion in breast cancer (BC). The aim of this study to elucidate the role of LILRB2 in BC progression. - Source: PubMed
Publication date: 2024/04/24
Jiang ZhiyuanHuang QianruChang YujieQiu YiranCheng HaoYang MengdiRuan ShunyiJi SuyuanSun JingWang ZhiyuXu ShengyuanLiang RuiDai XueyuWu KejinLi BinLi DanZhao Hui - The pathogenesis of acute pancreatitis mainly involves NLRP3 inflammasome-mediated pancreatic cell injury, although regulators of this inflammasome machinery are still not fully identified. Membrane-associated RING-CH 9 (MARCH9) is a member of MARCH-type finger proteins, which regulates innate immunity through catalyzing polyubiquitination of critical immune factors. The aim of present research is to examine the function of MARCH9 in acute pancreatitis. - Source: PubMed
Lin MinJin YuzhouWang FushuangMeng YaoHuang JinQin XihuFan Zhining