XAF1 Blocking Peptide
- Known as:
- X-linked inhibitor of apoptosis protein associated factor 1 Blocking Peptide
- Catalog number:
- 33r-8780
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Fitzgerald industries international
- Gene target:
- XAF1 Blocking Peptide
Related genes to: XAF1 Blocking Peptide
- Gene:
- XAF1 NIH gene
- Name:
- XIAP associated factor 1
- Previous symbol:
- -
- Synonyms:
- BIRC4BP, XIAPAF1, HSXIAPAF1
- Chromosome:
- 17p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2008-03-04
- Date modifiied:
- 2017-05-22
Related products to: XAF1 Blocking Peptide
Related articles to: XAF1 Blocking Peptide
- Carotid artery stenosis (CAS) is a major cause of ischemic stroke, yet reliable molecular biomarkers for early identification remain limited. - Source: PubMed
Publication date: 2026/05/25
Wu JiayiGuo ChunguangZhang LinfengCai GaopoLiu YiTang Kai - Gastrointestinal (GI) cancers can be attributed to the interplay between genetic and environmental factors. To date, apart from certain cancer syndromes, the genetic factors underlying familial GI cancers have not been clearly elucidated. - Source: PubMed
Publication date: 2026/05/04
Xu Guan-XinZhang HangWang Chang-XingZhang Ying-ZhiLv Ping-PingFeng ChunNing YaoShen MiaoZhang SaiJin MinYu Dan-Qing - Lung adenocarcinoma (LUAD) is the most prevalent subtype of lung cancer, the leading cause of global cancer-related mortality. Genetic mutations play critical roles in LUAD pathogenesis. This study aims to investigate the role of XIAP-associated factor 1 (XAF1) rs117407731, a nonsense mutation in certain splice variants (p.22W>*, TGG to TGA), in LUAD susceptibility and cellular function. Genotyping of XAF1 rs117407731 was conducted using blood samples of 103 LUAD patients and 229 healthy individuals. Multivariate logistic regression analysis was carried out to identify independent factors associated with LUAD risk. Immunofluorescence staining showed the expression of XAF1 and XIAP in LUAD tissues. TUNEL staining was employed for cell apoptosis analysis in patient LUAD tissues or mouse tumors. A549 cells were transduced with lentiviral vectors carrying wild-type or mutant XAF1 (XAF1-WT or XAF1-MUT) for functional experiments. XAF1 rs117407731 significantly increased susceptibility to LUAD. XAF1 protein expression was reduced, XIAP expression was elevated, and cell apoptosis was decreased in LUAD tissues from rs117407731 carriers. Overexpressing XAF1-MUT abated XAF1-mediated impairment of A549 cell proliferation and enhancement of apoptosis in vitro. XAF1-MUT overexpression impaired tumor suppression in the xenograft mouse model. XAF1 rs117407731 contributes to LUAD risk by impairing XAF1-mediated apoptosis. - Source: PubMed
Publication date: 2026/04/24
Xu GuanxinZhang HangZhang SaiYu Danqing - We constructed a gene coexpression network to uncover central key genes related to Sjögren's disease (SjD), and investigated the clinical significance of bone marrow stromal antigen 2 (BST2) in SjD. - Source: PubMed
Publication date: 2026/04/09
Ren TianZhou XinZhou EryeLiu CuipingWu JianChang XinChen Weichang - Endoplasmic reticulum stress (ERS) is linked to the progression of atherosclerosis (AS). The function of ERS-related genes (ERSRGs) in AS remains ambiguous, hence, this study sought to examined their association with AS. - Source: PubMed
Publication date: 2026/03/20
Liu XiaoyunPang HuiminPan XuediaoFan ShuxianDeng YiYu MengdieXie XinyuanPan Yufang