Ask about this productRelated genes to: STAU1 Blocking Peptide
- Gene:
- STAU1 NIH gene
- Name:
- staufen double-stranded RNA binding protein 1
- Previous symbol:
- STAU
- Synonyms:
- PPP1R150
- Chromosome:
- 20q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-22
- Date modifiied:
- 2016-10-05
Related products to: STAU1 Blocking Peptide
Related articles to: STAU1 Blocking Peptide
- STAU1, an RNA-binding protein central to the STAU1-mediated mRNA decay (SMD) pathway, promotes adipogenesis. This study reveals that STAU1 protein levels positively correlate with obesity severity. Adipose specific STAU1 deficient mice on a high-fat diet showed reduced weight, enhanced thermogenesis, and improved glucose tolerance. Deleting Stau1 gene in brown adipose tissue upregulated UCP1 protein. We further identified that STAU1 binds to the 3' UTR of Ucp1 mRNA. The β adrenergic receptor pathway enhances SMD activity, while inhibiting the cAMP-PKA pathway downregulates STAU1. Our findings establish STAU1 as a modulatory factor that adjusts thermogenic output in response to diverse thermogenic stimuli, providing insight into post-transcriptional regulation of energy balance and potential therapeutic targets for metabolic disease. - Source: PubMed
Publication date: 2026/06/03
Jiang ShuoChen SiyuanWan MengyaoNie ShiqiGu HaoLiu DihuiGuo ZihaoMeng XuanyuZhang YachengLiang Xiaodi - RNA-binding proteins (RBPs) play an essential role in development, normal functioning, and human disease. Staufen1 (STAU1) is an RBP that regulates mRNA degradation and subcellular localization, and is part of the ATXN2 protein complex. Previously, we showed that STAU1 is overabundant in patient fibroblasts and in mouse models of Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), and spinocerebellar ataxia type 2 (SCA2), where it is associated with impaired autophagic flux due to STAU1-mediated upregulation of mTOR translation. STAU1 overabundance and impaired autophagy cause accumulation of biomolecular condensates and abnormal unfolded protein response (UPR). We generated a mouse model expressing the entire human STAU1 gene (hSTAU1) in a bacterial artificial chromosome (BAC) construct. hSTAU1 in these mice was expressed in cerebral hemispheres, cerebellum, and spinal cord, as well as cultured cortical neurons and cortical and spinal cord astrocytes, and microglia. Expression of hSTAU1 caused dysregulated gene expression, abnormal autophagy, glial activation, and changes in neuronal marker proteins. All of these were significantly improved by reducing STAU1 abundance by RNAi, but exacerbated in BAC-STAU1 mice crossed with Prp-TDP-43(Q331K) transgenic mice. Similar results were also obtained in eye phenotypes in ALS- and SCA2-relevant fly models upon changing staufen-1 dosage. Despite the molecular changes, we observed no overt behavioral changes in mice up to 55 weeks of age, suggesting that STAU1 may function as an epistatic modifier of neuronal degeneration. The BAC-hSTAU1 mouse will be useful for developing therapies targeting the human STAU1 gene. - Source: PubMed
Publication date: 2026/05/14
Pulst Stefan MPaul SharanNguyen HieuDansithong WaruneeFigueroa Karla PGandelman MandiBonini Nancy MScoles Daniel R - Reliable normalization is essential for accurate quantitative real-time PCR (qRT-PCR) analysis, yet suitable reference genes have not been systematically evaluated in , an emerging marine experimental fish used in physiological and environmental research. In this study, 17 candidate reference genes were evaluated in five tissues (brain, gill, gonad, intestine, and liver) of sexually mature male and female under solvent control (DMSO), bisphenol A (BPA), cadmium (Cd), and sulfamethazine (SMX) treatment conditions. Gene-expression stability was assessed using the comparative ΔCt method, NormFinder, geNorm, BestKeeper, and the integrated RefFinder ranking. The results showed that reference-gene stability was strongly tissue-specific and analysis-dependent. The integrated RefFinder analysis identified , , , , and as the most stable genes in the pooled dataset, whereas , , and were the least stable. geNorm analysis indicated that two reference genes were sufficient for brain, gill, intestine, and liver, whereas four were required for the gonad and six for cross-tissue comparisons. These findings provide the first systematic basis for reference-gene selection in and establish an important methodological foundation for future qRT-PCR studies in this species, particularly in research on endocrine disruption, reproductive physiology, and marine ecotoxicology. - Source: PubMed
Publication date: 2026/05/05
Dong ZhongdianGao JiahaoLi XiaobinChen ZhishanLi JianjunLiao JianZhang YanpingWang ZhongduoGuo YusongZhang Ning - [This retracts the article DOI: 10.1016/j.omtn.2020.05.003.]. - Source: PubMed
Publication date: 2026/03/15
Ruan XueleiZheng JianLiu XiaobaiLiu YunhuiLiu LiboMa JunHe QianruYang ChunqingWang DiCai HengLi ZhenLiu JingXue Yixue - Dysregulation of integrins plays an important role in cancer metastasis, but its underlying mechanisms remain largely unexplored. Here we report that the RNA-binding protein STAU1 enhances mRNA stability of integrin β5 (ITGB5), forming a self-perpetuating loop that drives colorectal cancer (CRC) metastasis. STAU1 was significantly upregulated in CRC, particularly in metastatic tissues, and correlated with poor patient outcomes. STAU1 knockdown suppressed CRC cell metastasis in vitro and in vivo, while its overexpression promoted metastasis. ITGB5 mRNA was identified as a novel target of STAU1 and mediated its pro-metastatic effects. Mechanistically, STAU1 directly bound the 3' untranslated region of ITGB5 mRNA to stabilize it. We further identified transcription factor FOXP3 as a downstream effector of ITGB5 in CRC cells. STAU1-mediated ITGB5 upregulation increased FOXP3 phosphorylation at serine 418, which enhanced FOXP3 binding to the STAU1 promoter and activated its transcription, establishing a STAU1-ITGB5-FOXP3 positive feedback loop. This loop was augmented in CRC specimens from patients with distant metastasis. Our study elucidates a novel RBP-integrin regulatory axis in CRC metastasis and proposes the STAU1-ITGB5-FOXP3 loop as a prognostic biomarker and promising therapeutic target for metastatic CRC. - Source: PubMed
Publication date: 2026/03/06
Wang YingeLi DanxiuWei DanMiao GeLiu YanxingZhang WenyaoGuo XingxianYu JianingMa WanqiGuo ZhiyuWang ChenNie YongzhanCao TianyuJin HaifengZhao XiaodiLu Yuanyuan