Ask about this productRelated genes to: HTR2C Blocking Peptide
- Gene:
- HTR2C NIH gene
- Name:
- 5-hydroxytryptamine receptor 2C
- Previous symbol:
- HTR1C
- Synonyms:
- 5-HT2C, 5HTR2C
- Chromosome:
- Xq23
- Locus Type:
- gene with protein product
- Date approved:
- 1994-08-29
- Date modifiied:
- 2019-04-23
Related products to: HTR2C Blocking Peptide
Related articles to: HTR2C Blocking Peptide
- Antipsychotic-induced weight gain (AIWG) is a major clinical concern, affecting approximately 30% of patients. Clinical predictors explain only part of AIWG risk. Genetic and molecular variations are hypothesized to contribute to susceptibility. The purpose of this review is to summarize recent results to identify replicated and novel findings. - Source: PubMed
Publication date: 2026/07/21
Kronenbuerger MartinYoshida KazunariLi Pei YuanTavakoli EmytisMagarbeh LeenElsheikh Samar S MGorbovskaya IlonaZai Clement CFleischmann RobertZai GwynethKloiber StefanKennedy James LMüller Daniel JTiwari Arun K - The preBötzinger Complex is among the few neural circuits where selective elimination of defined neuronal subpopulation is sufficient to destabilize a core autonomic function and can fatally impair breathing. Within this circuitry, neurons expressing the neurokinin-1 receptor () and somatostatin () are critical subpopulations; neurons respond to the neuropeptide substance P and are necessary for maintaining inspiratory rhythms, and ablation of neurons results in apneas. To further dissect and analyze the specific roles for and cell types, we conducted a comprehensive transcriptomic analysis using single-nucleus RNA sequencing of enriched preBötC from neonatal C57BL/6J mice. Because respiratory rhythmogenesis is an inherently electrophysiological process, we focused on the ion channel transcriptomes of Tacr1 + and Sst+ populations to resolve the molecular underpinnings of their distinct contributions to breathing. A balanced Random Forest classifier distinguished Tacr1 from Sst neurons with higher accuracy, indicating a distinct and relatively homogeneous ion channel identity in Tacr1 neurons. Differential expression analyses identified coordinated upregulation of , and genes in Tacr1 neurons. Tacr1 neurons further exhibited elevated expression of the NALCN channelosome subunits and selective enrichment genes of and neuromodulatory receptor genes. Together, these findings define a molecularly distinct ion channel composition of Tacr1 neurons and imply convergent substance P linked mechanisms: TRPC5-mediated I and NALCN-mediated sodium leak conductance supporting rhythmic inspiratory activity, providing a molecular framework for targeted interrogation of respiratory circuit function. - Source: PubMed
Publication date: 2026/07/02
Bhagavan HemalathaWei Aguan DOliveira Luiz MRamirez Jan-Marino - Although the 5-hydroxytr-yptamine 2C receptor (5-HT2C) receptor agonists have demonstrated efficacy in mitigating sensorimotor gating deficits in the schizophrenic animal model of glutamatergic dysfunction, the precise neural mechanisms underlying these effects remain incompletely understood. This study investigates how 5-HT2C receptor activation improves sensorimotor gating and cognitive function by modulating Excitation/Inhibition balance in the medial prefrontal cortex (mPFC). - Source: PubMed
He LichunZhang QiuxiaLuo YanciCao YushanWu ShangZhu HuifengChen Weihai - Abdominal fat thickness (AFT) is a crucial indicator for assessing fat deposition in White Feather broilers. Previous genome-wide association studies (GWAS) have primarily focused on single-point measurements of abdominal fat, with limited attention given to longitudinal phenotype records. Compared to traditional GWAS models, the longitudinal data-based GWAS (LONG-GWAS) model accounts for temporal phase effects, thereby more effectively controlling the false positive rate. This study conducted a genome-wide association analysis on 1654 White Feather broilers at four distinct ages during the laying period of broiler breeders (25, 27, 35, and 43 weeks). Three SNP loci associated with fat were identified (rs16341267, rs740644432, and rs15049519), which were annotated to three candidate genes: FDFT1, HTR2C, and ALDH3A2. These genes are involved in regulating lipid metabolism, energy balance, and fat deposition. This study provides new insights into the genetic basis of abdominal fat thickness in White Feather broilers and offers stage-specific marker information that can accelerate precision breeding for abdominal fat control in white feathered broilers. - Source: PubMed
Li PenghaoLuo NaYing FanZhu DanLiu DaweiSong XianyiWen JieZhao GuipingAn Bingxing - Major depression and suicide are critical public health concerns, particularly in underrepresented populations with unique genetic and sociocultural contexts. The Maya-mestizo population presents the highest suicide rates in the country but remains understudied in psychiatric genetics. This study evaluated the association between three genetic variants, rs7305115 (TPH2), rs6265 (BDNF), and rs2428707 (HTR2C), and the presence of major depression, melancholic subtype, and suicide risk in Maya-mestizo adults. A total of 598 participants were recruited from urban and rural areas. Psychiatric evaluations were performed using the MINI 5.0 (DSM-IV), and functional status was assessed with the Karnofsky scale. Genotyping was performed with TaqMan assays, and ancestry was confirmed with ancestry-informative markers. Analyses included Hardy-Weinberg equilibrium testing and logistic regression models adjusted for sex and included age, body mass index, Karnofsky performance scale score, and sociodemographic variables as covariates. The prevalence of major depression was 38.9%, while suicide risk reached 24.7%. The rs2428707 variant of HTR2C was significantly associated with major depression (OR 2.31, 95% CI 1.03-5.18, p = 0.041). Variants in TPH2 and BDNF were associated with the melancholic subtype. No statistically significant associations were found with suicide risk, though overlap with depressive phenotypes suggests shared vulnerability. This first report of psychiatric genetics in the Maya-mestizo population highlights the need for culturally and genetically tailored interventions. - Source: PubMed
Publication date: 2026/04/12
Menjivar MartaBravo ErandiRivera-Balancan MargaritaEspinoza Barbara Itzel Pena