Ask about this productRelated genes to: CENPI Blocking Peptide
- Gene:
- CENPI NIH gene
- Name:
- centromere protein I
- Previous symbol:
- FSHPRH1
- Synonyms:
- LRPR1, CENP-I, Mis6
- Chromosome:
- Xq22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1996-10-26
- Date modifiied:
- 2014-11-19
Related products to: CENPI Blocking Peptide
Related articles to: CENPI Blocking Peptide
- Hepatocellular carcinoma (HCC) is characterized by high recurrence rates and limited targeted therapies. Centromere protein I (CENPI), a core kinetochore component linked to chromosomal instability, is dysregulated in multiple malignancies, yet its role and mechanism in HCC progression remain incompletely elucidated. - Source: PubMed
Publication date: 2026/05/12
Liu DemengYang PeihaoWang JiyaoLi JunleWang XinGu XiaohuiLiu ChaoFang Yan - Juvenile European seabass (Dicentrarchus labrax) were exposed to environmentally relevant 6PPD-quinone (2.85 µg/L) for five days to evaluate transcriptional, oxidative, and antioxidant responses and histopathology. The liver showed the strongest gene induction: cdc28 (∼75×), bax (48×), spc25 (45×), and hsp70 (42.5×). Kidney responses were moderate, with bax up ∼5.5× and hsp70 and casp9 ∼2×, while pcna, cenpi, cenpf, and cdc28 were downregulated (0.32-0.66×). Spleen and intestine exhibited marked upregulation of spc25, cenpf, cenpi, and bcl2 (up to ∼34.6× and 16×, respectively), whereas trip13, bax, and bcl2 were unchanged in spleen. Gills displayed strong trip13 (∼32.5×) and spc25 (∼13.7×) induction but downregulation of bax and bcl2. Oxidative DNA damage (8-OHdG) increased in all organs except skin, peaking in spleen; N-myc protein rose in spleen. Catalase activity decreased in liver, kidney, and skin but increased in spleen; MDA decreased in most tissues except skin. Histopathology revealed multifocal hepatic necrosis and vacuolation, splenic fibrosis with hemorrhage and lymphoid depletion, intestinal villous sloughing with submucosal inflammation, severe myositis, epidermal desquamation, and gill lamellar damage. In conclusion, short-term exposure to environmentally relevant 6PPD-quinone elicits organ-specific molecular, oxidative, and pathological alterations in juvenile seabass, indicating significant multisystemic toxicity and potential population-level risks and warrants further ecological investigation. - Source: PubMed
Publication date: 2026/04/19
Abo-Al-Ela Haitham GAl Wakeel Rasha AZaki Abeer GamalElkatatny Nasema MahmoudAbdelatty AlaaAssas MonaZaid Attia A AbouElnaggar Mahmoud MAbdo Safaa E - Cell cycle checkpoint-related genes (CCCRGs) are implicated in the development and progression of hepatocellular carcinoma (HCC). However, their precise roles and underlying mechanisms remain insufficiently characterized and require further investigation. This study aimed to explore the prognostic significance of CCCRGs in HCC, and to investigate the mechanism by which they promote the progression of HCC. - Source: PubMed
Publication date: 2025/09/24
He RishengXu YiZhang PengboYu LiangMa JianCui Yunfu - An integral component of centromeric proteins, centromere protein I (CENPI) plays a pivotal role in chromosomal segregation and alignment. Nonetheless, there has been little investigation on its link to oral squamous cell carcinoma (OSCC).This study demonstrated that CENPI was significantly upregulated in OSCC tissues and cell lines compared to normal controls. Functional assays revealed that CENPI silencing suppressed OSCC cell proliferation, colony formation, migration, and invasion, and induced G1 phase cell cycle arrest. Consistently, CENPI knockdown inhibited tumor growth in a xenograft mouse model. Mechanistically, CENPI was found to directly bind to the E2F4 promoter and enhance its transcription. Crucially, the tumor-suppressive effects of CENPI knockdown were effectively rescued by E2F4 overexpression. In conclusion, the CENPI-E2F4 axis plays a critical oncogenic role in OSCC progression, presenting a promising novel therapeutic target for this malignancy. - Source: PubMed
Publication date: 2025/11/22
Chen YiDuan FeiDuan XinxingWen XutaoYu XiongLi Dan - Glioblastomas (GBMs) are common malignant brain tumors that currently lack effective therapies. Therefore, exploring potential molecular regulatory mechanisms is crucial for developing new treatment strategies. Centromeric protein I (CENPI) is a member of the centromere protein family that affects the development of various cancers. Using the TCGA, we found that CENPI was significantly overexpressed in GBMs. CENPI knockdown repressed the proliferation, migration, and invasion ability of GBM cells in vitro. Gene enrichment analysis (GSEA) demonstrated that CENPI was enriched in arginine (Arg) and proline (Pro) metabolic pathways; CENPI knockdown inhibited the metabolism of these two amino acids in GBM cells. Through JASPAR prediction, dual luciferase and ChIP detection, FOXM1 was confirmed as a key transcriptional activator of CENPI. FOXM1 knockdown also depressed Arg and Pro metabolism in GBM cells thereby reducing their malignant phenotype whereas CENPI overexpression or exogenous addition of L-Arg and L-Pro restored the pro-cancer trend induced by FOXM1. Additional experiments demonstrated that the FOXM1/CENPI axis regulated the metabolism of Pro and Arg to promote GBM malignant progression modelled in vitro. In summary, our research indicated that FOXM1/CENPI signaling enhances the proliferation, migration, and invasion of GBM cells by promoting the metabolism of Arg and Pro. - Source: PubMed
Weng MeilingZhu Xiaoping