Ask about this productRelated genes to: FAAH2 Blocking Peptide
- Gene:
- FAAH2 NIH gene
- Name:
- fatty acid amide hydrolase 2
- Previous symbol:
- AMDD
- Synonyms:
- RP11-479E16.1, FLJ31204, FAAH-2
- Chromosome:
- Xp11.21
- Locus Type:
- gene with protein product
- Date approved:
- 2006-07-11
- Date modifiied:
- 2016-10-05
Related products to: FAAH2 Blocking Peptide
Related articles to: FAAH2 Blocking Peptide
- This study evaluated the properties of fatty acid amide hydrolase 2 (FAAH2) as a drug-metabolizing enzyme, specifically its substrate specificity and functionality. We used expression systems and various microsomes, with DS-8500a and its analogs as model substrates for xenobiotic hydrolysis. Among FAAH1, FAAH2, carboxylesterase 1, and carboxylesterase 2, FAAH2 exhibited significant hydrolytic activity, producing M20, a metabolite of DS-8500a. FAAH2 showed the highest affinity for the substrate DS-8500a with a Michaelis constant, which agreed with that observed in human liver microsomes. Furthermore, the FAAH2 protein levels in human liver microsomes showed a positive correlation with the amounts of M20 production. These findings suggested that FAAH2 is the primary enzyme responsible for metabolizing DS-8500a. We also found that human liver microsomes showed interindividual variability in FAAH2 activity with approximately a 15-fold maximal difference and a different extent of inhibitory effect by an FAAH2 inhibitor on M20 formation, possibly affecting the pharmacokinetic profile of FAAH2 substrates. Experiments using DS-8500 analogs suggested that structural modifications in the ethanolamide moiety influence the hydrolytic activity of FAAH2. Modifications to this moiety led to alterations not only in the hydrolytic activity of FAAH2 but also in the substrate specificity for FAAH1. In conclusion, we have demonstrated for the first time that FAAH2 catalyzes the hydrolysis of xenobiotics. This hydrolytic enzyme may affect the pharmacokinetics of FAAH2 substrates. SIGNIFICANCE STATEMENT: This study focuses on fatty acid amide hydrolase 2 (FAAH2) as a hydrolytic enzyme capable of metabolizing not only fatty acid amides but also xenobiotics, using DS-8500a as a model substrate. This work highlights the property of FAAH2 as a drug-metabolizing enzyme, emphasizing the need for evaluations with inhibitors such as cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester when xenobiotics are hydrolyzed. In addition, the quantification of FAAH2 protein levels and the assessment of individual variability provide insights into the influence of FAAH2 on drug metabolism across different individuals. - Source: PubMed
Publication date: 2026/02/09
Makino ChieChiashi TakumaHayashi MayumiOgura YujiNamiki HidenoriHonda TomoyoWatanabe AkikoShiozawa HideyukiTakakusa HideoNakai DaisukeKobayashi Kaoru - X chromosome-wide association studies (XWAS) have successfully identified risk loci on the X chromosome associated with Parkinson's disease (PD) susceptibility. However, only three such studies have been completed to date. Here, we present the first XWAS using an African cohort, comprising 690 PD cases and 826 controls. We applied an established XWAS workflow to perform male- and female-stratified analyses, as well as a combined meta-analysis. The male-stratified analysis identified five significant variants, including one lead locus (rs200539602), while the female-stratified analysis revealed 29 significant variants and two lead loci (rs2499550 and rs58045540), where rs2499550 is an upstream variant of the protein-coding gene . The remaining female-stratified significant variants are expression quantitative trait loci for , , and , which are highly expressed in the brain and nerve tissues, making them strong candidates for further investigation. One previously reported PD XWAS locus (rs28602900) was also replicated at a significance threshold of 0.05. The meta-analysis identified five variants surpassing chromosome-wide significance, including two lead loci (rs140715059 and rs141026964), the latter has no significant expression quantitative trait locus information but lies closest to the protein-coding gene , which may warrant further follow-up. None of the meta-analysis signals replicated in prior neurodegenerative disease XWAS. Overall, this study provides novel insights into the contribution of the X chromosome to PD susceptibility and represents the first PD XWAS to include participants of African ancestry, highlighting the importance of extending genetic studies to diverse populations. - Source: PubMed
Publication date: 2025/12/26
Step KathrynWaldo EmilyLeal Thiago PeixotoMendes MarlaBardien SorayaMata Ignacio F - Preeclampsia is classified as either a more severe early onset or a more prevalent late-onset form. Lower PlGF (placental growth factor) and increased sFlt-1 (fms-like tyrosine kinase-1) in maternal circulation are promising biomarkers, yet they lack specificity for preeclampsia. - Source: PubMed
Publication date: 2025/10/01
Andresen Ina JRomero RobertoWesterberg Ane CThan Nándor GáborGomez-Lopez NardhyBhatti GauravAhmodu OladejoGudicha Dereje WMeyyazhagan ArunAwonuga AwoniyiChaiworapongsa TinnakornBryant David RMichelsen Trond MTarca Adi L - Fatty acid amide hydrolase 2 (FAAH2) is an enzyme involved in the degradation of endocannabinoids in humans. Altered FAAH2 activity has been implicated in various neurological and psychiatric conditions. We describe a male patient presenting with anxiety disorder, autistic-like traits, and borderline intellectual functioning (BIF), as well as metabolic disturbances including obesity and hepatic steatosis. Trio-based whole-exome sequencing (WES) identified the novel hemizygous c.988C > A (p.Gln330Lys) variant in the X-linked FAAH2 gene, which currently lacks an associated MIM phenotype. Structural modelling suggested that the variant induces multiple alterations in the amidase signature (AS), a key functional domain of the enzyme. These findings contribute to the emerging evidence supporting FAAH2 as a candidate gene for a neurodevelopmental phenotype with metabolic involvement, consistent with an X-linked inheritance pattern. - Source: PubMed
Publication date: 2025/07/29
Vinci MirellaGreco DonatellaTreccarichi SimoneMusumeci AntoninoGloria AngeloFederico ConcettaSaccone SalvatoreCalì FrancescoSirrs Sandra - Endometrial receptivity is a critical determinant of successful embryo implantation and pregnancy. Gonadotropin-releasing hormone (GnRH) analogues are widely used in in vitro fertilization (IVF) but their effects on endometrial receptivity remain incompletely understood. This study aims to investigate the impact of GnRH analogues on endometrial receptivity through various in vitro models. - Source: PubMed
Publication date: 2025/05/10
He ZhuqiangGuo NaYao YangchengZhou JieDeng TaoranDu YaoyaoLi YufengYin Li