Ask about this productRelated genes to: TMTC2 Blocking Peptide
- Gene:
- TMTC2 NIH gene
- Name:
- transmembrane and tetratricopeptide repeat containing 2
- Previous symbol:
- -
- Synonyms:
- DKFZp762A217
- Chromosome:
- 12q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-06
- Date modifiied:
- 2014-11-18
Related products to: TMTC2 Blocking Peptide
Related articles to: TMTC2 Blocking Peptide
- Keloid (KD) is a benign cutaneous fibrotic disorder characterized by excessive proliferation of dermal fibroblasts. Mannose plays a key role in cellular metabolism, yet its specific mechanism associated with KD remains unclear. Therefore, identifying mannose metabolism-related potential biomarkers and their regulatory mechanisms in KD is crucial. - Source: PubMed
Publication date: 2026/06/10
Chen JiaoquanXiong XiaoyuLiang BihuaGong YeqingMa ShaoyinZhou XinZhu HuilanLin LingLin Rihua - Kongshan cattle is an indigenous breed from Sichuan Province, China, characterized by their excellent meat quality, high fertility, strong disease resistance, and remarkable environmental adaptability. However, their genomic diversity has not been systematically studied. In this work, we performed whole-genome sequencing of 30 Kongshan cattle from a breeding farm and integrated these data with 113 representative commercial and indigenous cattle breeds worldwide to investigate their population structure and genetic diversity. We further analyzed the ancestral contributions to the development of the breed. The population structure revealed that Kongshan cattle possess four types of ancestral components: East Asian indicine (0.5974), East Asian taurine (0.3464), European taurine (0.0483), and Indian indicine (0.0079). The population also exhibits high nucleotide diversity, second only to pure East Asian indicine cattle. We inferred the ancestry of each variable site in the genome and, in combination with integrated haplotype score analysis, identified candidate genes related to meat quality (, , , , and ), immunity (, , , , , , , and ), and environmental adaptability (, , , , and ). These findings provide valuable insights into the evolutionary history and ancestral origins of Kongshan cattle and contribute to the broader understanding, conservation, and sustainable utilization of indigenous Chinese cattle genetic resources. - Source: PubMed
Publication date: 2025/12/12
Bai MengmengYang KaiMa XiaohuiBian ChenqiWang WeiYi JunChen NingboLei ChuzhaoXia Xiaoting - A low ankle-brachial Index (ABI) is an established condition for peripheral artery disease (PAD) and cardiovascular disease risk. The search for genetic determinants of the ankle-brachial index (ABI) is important to better understand molecular patho-cmechanisms of PAD and its commonalities with cardiovascular diseases (CVD), supporting development of new drug targets and tailored preventive or therapeutic measures. - Source: PubMed
Publication date: 2025/11/18
Rode MichaelRosolowski MaciejHorn KatrinHenger SylviaTeren AndrejWirkner KerstinThiery JoachimLoeffler MarkusPott JanneKirsten HolgerScholz Markus - The ovary is among the earliest organs to undergo age-related degeneration, limiting the reproductive potential of elite horses and constraining the growth of the equine industry. Follicular development during estrus is a key determinant of fertility, yet the molecular mechanisms underlying its decline, particularly at the level of specific ovarian cell types, remain poorly understood in equids. Here, we constructed a single-cell transcriptomic atlas to investigate ovarian changes in Kazakh horses. Using single-cell RNA sequencing (scRNA-seq), we profiled 112,861 cells from follicle-containing and follicle-absent ovaries, identifying nine distinct ovarian cell types and their subtypes, each with distinct gene expression signatures. Functional enrichment analyses revealed cell type-specific engagement in biological pathways, including ECM-receptor interaction, PI3K-Akt signaling, and oxytocin signaling. Gene expression patterns indicated tightly regulated processes of ovarian activation and cell differentiation. Notably, stromal cells exhibited high expression of , , and , while smooth muscle cells (SMCs) were marked by elevated levels of , , and . Moreover, cell-cell interaction analyses revealed robust signaling interactions among SMCs, endothelial cells, neurons, and proliferating (cycling) cells. Together, these findings provide a comprehensive single-cell transcriptomic map of normal and abnormal ovarian states during estrus in Kazakh horses, offering novel insights into the cellular mechanisms of follicular development and identifying potential diagnostic biomarkers and therapeutic targets for ovarian quiescence in equids. - Source: PubMed
Publication date: 2025/10/02
Ren WanluZhou JunZhu JianpingZhang JianguangZhao XueguangYao Xinkui - Esophageal cancer (EC) has a high incidence and is highly invasive. It is meaningful to employ invasion-related genes (IRGs) to predict patients' prognosis. - Source: PubMed
Publication date: 2025/09/24
Deng XueqiongLiu Yiming