Ask about this productRelated genes to: CSH1 Blocking Peptide
- Gene:
- CSH1 NIH gene
- Name:
- chorionic somatomammotropin hormone 1
- Previous symbol:
- -
- Synonyms:
- hCS-A, CSA, PL, CSMT, FLJ75407
- Chromosome:
- 17q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-01-15
Related products to: CSH1 Blocking Peptide
Related articles to: CSH1 Blocking Peptide
- In this work, a set of novel chitosan-derived zwitterionic aerogels was synthesized graft polymerization of acrylamide (Am) and 2-(-3-sulfopropyl-','-dimethylammonium)ethyl methacrylate (DMAPS). The resulting copolymer aerogel underwent chemical crosslinking the covalent bonds formed with ','-methylenebisacrylamide (MBA), and ionic crosslinking through the electrostatic interactions between the cationic chitosan-grafted poly(DMAPS) backbone and the anionic groups of lignosulfonic acid (LSA). The morphological examination of the different aerogels by scanning electron microscopy suggested the formation of a fibrous network with varying degrees of porosity, depending on the type and amount of crosslinkers used. FT-IR, SEM, EDAX, TGA, and XRD techniques were employed to confirm the aerogel synthesis. The antimicrobial potency of the as-prepared aerogels was evaluated primarily against . This strain was selected as a representative Gram-negative model organism due to its high prevalence in wastewater and its relevance to environmental contamination. Preliminary investigation of the tested aerogels demonstrated that both CSH1 and CSH2 aerogels were efficient in eradicating from nutrient broth media at 2000 ppm after 4 h. In addition to growth-inhibition studies, the interaction between the aerogels and cells was examined using transmission electron microscopy and zeta potential measurements. Furthermore, the effects of aerogel dosage and contact time on antibacterial performance were systematically assessed. The results indicated that contact time is a critical factor for aerogel potency against . A 4 h treatment outperformed both 2 and 24 h exposures. CSH2 was selected for further evaluation using a real wastewater sample collected from a local drain. In field trials, CSH2 reduced total coliforms, fecal coliforms, , and counts to levels deemed safe by WHO guidelines, and improved wastewater physicochemical properties. Overall, the CSH2 polymer offers a viable approach for mitigating pathogen risks in wastewater for sustainable agricultural management. - Source: PubMed
Publication date: 2026/05/20
Ali DoaaKamel SamirEl-Sayed Naglaa Salem - This study aimed to determine the in vitro effects of visfatin on selected endocrine mediators in the human placenta. Using placental BeWo cells and villous explants from normal pregnancies and those complicated by intrauterine growth restriction (IUGR), preeclampsia (PE), and gestational diabetes mellitus (GDM), we determined the effects of visfatin on 3β-hydroxysteroid dehydrogenase (3β-HSD), aromatase (CYP19), human chorionic gonadotropin (hCG), human placental lactogen (hPL), placental growth hormone (GH2) expression, and the secretion of progesterone (P), estradiol (E) and mentioned protein hormones. We also investigated the effects of visfatin on the phosphorylation of protein kinase A (PKA), and hormone secretion after the pharmacological inhibition of insulin receptor (INSR), extracellular signal-regulated kinase 1/2 (ERK1/2), and PKA. We noted that visfatin increased or decreased the mRNA and protein expression of HSD3B1/3β-HSD, CYP19A1/CYP19, CGB3/hCG, CSH1/hPL, and GH2/GH2 in the tested groups. Additionally, visfatin lowered the secretion of P, E, hCG, hPL, and GH2 in BeWo cells and normal placenta, but modulated it in placenta explants from the pathological groups. The secretion of E, hPL and GH2 was mediated by INSR, ERK1/2, and PKA, while P by INSR and ERK1/2. These data indicated that visfatin acting via selected molecular pathways may be an important regulator of placental endocrine function during normal and complicated pregnancies. - Source: PubMed
Publication date: 2026/05/24
Dawid MonikaGieras WiktoriaMilewicz TomaszRak Agnieszka - Saccharomyces cerevisiae exhibits a remarkable ability to tolerate high concentrations of ethanol during fermentation, yet the molecular basis underlying this adaptive trait remains incompletely understood. Here, we identify the biosynthesis of the complex sphingolipid mannosylinositol phosphorylceramide (MIPC) as a key determinant of ethanol tolerance in S. cerevisiae. Cells lacking the MIPC synthases Csg1 and Csh1 exhibited pronounced ethanol hypersensitivity and loss of viability. This defect was associated with impaired maintenance of cell wall integrity under ethanol stress and was further exacerbated by disruption of the Rim101 transcription factor or the cell wall integrity MAP kinase Slt2 pathway. Notably, ethanol exposure triggered Rim101-dependent eisosome remodeling specifically in MIPC-deficient cells, indicating altered plasma membrane organization in response to ethanol stress. Hypersensitivity of MIPC-deficient cells extended to alcohols with different carbon chain lengths, suggesting a broader defect in alcohol-induced cellular stress responses. Consistent with these defects, MIPC-deficient cells showed reduced growth and survival under high-glucose fermentative conditions that promote ethanol production. Together, our findings demonstrate that MIPC biosynthesis supports cell surface adaptation to ethanol stress by maintaining cell wall integrity and regulating plasma membrane organization, providing new insights into ethanol tolerance and its relevance to fermentation performance. - Source: PubMed
Publication date: 2026/05/21
Sugihara SakiSusami ReoKoga AyanoIto ShionNakagawa TomoyukiTani Motohiro - The placenta is critical for fetal development and mediates effects of pregnancy complications on offspring metabolic health yet remains poorly characterized in genomic studies. Existing transcriptomic analyses rely on adult tissue reference annotations, overlooking developmentally important splicing diversity. Using largest-in-class long-read RNA-seq (n = 72), we create a comprehensive placental transcriptome reference identifying 37,661 high-confidence isoforms (14,985 previously unannotated) across 12,302 genes (2,759 previously unannotated). Contrary to characterizations of the placenta as a transcriptomic void, we find transcriptional breadth and complexity comparable to adult tissues, with high splicing diversity of obesity- and growth-related gene transcripts, including 108 distinct CSH1 (placental lactogen) isoforms. Applying this reference to short-read RNA-seq from diverse populations (n = 352) reduced inferential uncertainty in isoform quantification by approximately 30%. We find placental transcription mediated 36% of gestational diabetes mellitus effects on birth weight, with ancestry-specific effects including previously unannotated CSH1 isoforms mediating larger effects in European (24.4%) than Asian (13.4%) populations. These findings illustrate the importance of tissue-matched, long-read annotations for isoform-resolved transcriptomics. - Source: PubMed
Publication date: 2026/04/02
Bresnahan Sean TYong Hannah E JNemani AryunWu William HLopez SierraChan Jerry Kok YenWhite FrédériqueJacques Pierre-ÉtienneHivert Marie-FranceChan Shiao-YngLove Michael IHuang Jonathan YBhattacharya Arjun - Vaspin, a visceral-adipose-tissue-derived serine protease inhibitor, is involved in the development of obesity, insulin resistance, energy metabolism, and reproduction. Its expression and regulation were studied in the human and rat placenta; however, the role of this adipokine in placental endocrine function has never been studied. The present study aimed to investigate the effects of vaspin on the endocrine function of the human placental syncytiotrophoblasts BeWo cell line and villous explants collected during the third trimester of pregnancy. BeWo cells (n=4) or villous explants (n=3) were cultured with vaspin at doses of 0.1, 1, and 10 ng/ml for 24, 48, and 72 h. The levels of progesterone (P4), estradiol (E2), human chorionic gonadotropin (hCG), and human placental lactogen (hPL) were determined in the culture medium enzyme-linked immunosorbent assay (ELISA). In addition, the mRNA and protein expression of 3β-hydroxysteroid dehydrogenase (), aromatase (), , and were determined via real-time PCR and Western blotting, respectively. We analyzed the role of pharmacological inhibitors of extracellular signal-regulated kinase (ERK1/2) and protein kinase A (PKA) in the vaspin action on hormone secretion. We observed that vaspin has a modulatory effect on the secretion and expression of placental hormones in BeWo cells and placentas from physiological pregnancies. However, in most cases, the effect was inhibitory on the parameters examined. Moreover, we noted that PKA participates in reducing E secretion, while ERK1/2 is involved in hCG level. These findings indicate that vaspin is a new regulator of human placental endocrine function. - Source: PubMed
Publication date: 2025/09/16
Gieras WDawid MMilewicz TRak A