Ask about this productRelated genes to: CYP8B1 Blocking Peptide
- Gene:
- CYP8B1 NIH gene
- Name:
- cytochrome P450 family 8 subfamily B member 1
- Previous symbol:
- -
- Synonyms:
- CYP12
- Chromosome:
- 3p22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-06-25
- Date modifiied:
- 2015-12-09
Related products to: CYP8B1 Blocking Peptide
Related articles to: CYP8B1 Blocking Peptide
- Jieshiqing Capsule (JSQ) is a classic traditional Miao medicine with notable clinical efficacy in clearing damp-heat and promoting bile flow to eliminate gallstones. However, the lack of a quality evaluation standard centered on its sovereign herb, together with unclear molecular mechanisms, greatly limits the modernization and broader application of this formulation. - Source: PubMed
Publication date: 2026/06/24
Yongbo XiziLi XingChen HuarongJiang KunXia WenFeng YulinHe Mingzhen - Hepatic ischemia-reperfusion injury (IRI) is a complex event influenced by interconnected immune and metabolic processes. Steatotic livers are especially sensitive to IRI, but the crosstalk between innate inflammatory responses and lipid metabolic dysregulation in this context is not well understood. Using transcriptomic profiling in a murine high-fat diet (HFD) model, we assessed immune and metabolic responses to hepatic IRI and examined the effects of N-acetylcysteine (NAC). In steatotic livers, IRI induced the upregulation of inflammatory mediators, including TLR/NF-κB-associated genes (, , ) and neutrophil-associated genes (, ), accompanied by the downregulation of lipid and cholesterol metabolism-related genes, including , , , and . NAC supplementation attenuated inflammatory gene expression and restored key lipid biosynthetic regulators. We then performed targeted lipidomic analysis to determine whether NAC-mediated transcriptional changes were reflected at the lipid level and observed a significant increase in total phosphatidylcholine and sphingomyelin in steatotic livers following IRI. Finally, to assess the contribution of innate immune cells to hepatic IRI, we quantified neutrophils and macrophages in HFD+NAC IRI and HFD IRI livers. We found that NAC supplementation reduced hepatic neutrophil accumulation and markedly decreased LCN2 expression following IRI. - Source: PubMed
Publication date: 2026/05/19
Kang JimanPatil DigvijayHackett RyanCui YukiOza KeshaRutkowski AbigailLiggett Jedson RLi HenghongRanjit SumanKwon DongHyangKallakury BhaskarAlbanese ChrisGondolesi Gabriel EEkong UdemeCui WanxingKhan KhalidFishbein Thomas MKroemer Alexander - Cholesterol (CHO)/bile acids (BAs) homeostasis is critically involved in hepatocellular carcinoma (HCC), yet the underlying mechanisms and the specific regulatory role of CYP8B1-a key enzyme maintaining this balance-remain poorly defined. This study seeks to clarify the roles of CYP8B1 and its regulated CHO/BA homeostasis in the initiation and progression of HCC driven by aberrant RAS/ERK signaling. - Source: PubMed
Publication date: 2026/05/23
Li JuanLi HuilingDong LiliYao LiangDong XiaoyingGuo YingyanPu ChunwenWang AiguoChen Jun - Circadian regulation of gene expression relies on the coordinated action of core clock components, tissue-specific transcription factors, and epigenetic mechanisms, including dynamic enhancer-promoter interactions. Although rhythmic chromatin looping has been described in the liver, the transcription factors that mediate these temporal interactions remain poorly defined. Here, we identify the nuclear receptor NR5A2 as a key regulator of circadian enhancer-promoter communication in the mouse liver. We show that NR5A2 protein levels fluctuate over the 24-h cycle, peaking around Zeitgeber time 0 (ZT0). Genome-wide analysis reveals that NR5A2 preferentially binds H3K27ac-enriched enhancer regions, many of which engage in chromatin looping with promoters of metabolic genes. High-resolution 4C-seq analyses demonstrate that promoters of Elovl5 and Ppp1r3c dynamically interact with NR5A2- and H3K27ac-enriched enhancers in a time-dependent manner, with maximal interactions at ZT0 and reduced contacts at ZT12. Pharmacological inhibition of NR5A2 in vivo leads to alterations in hepatic glycogen and cholesterol accumulation, attenuates the rhythmic expression of circadian metabolic genes, including Ppp1r3c, Cyp8b1, and Elovl5, and disrupts enhancer-promoter contact frequencies at the Elovl5 locus. Together, our findings provide in vivo evidence that NR5A2 integrates circadian and metabolic regulation by modulating enhancer-promoter chromatin interactions, thereby shaping rhythmic liver gene expression. - Source: PubMed
Publication date: 2026/05/23
Román-Figueroa AbrahamGómora-García Juan CarlosTenorio-Hernández LuisPérez-Molina RosarioJácome-López KarinaFurlan-Magaril Mayra - Fatty liver is a common metabolic disease in dairy cows during early postpartum period, which is characterized by excessive hepatic triacylglycerol (TAG) accumulation. However, the mechanisms of bile acid (BA) metabolism in dairy cows experiencing fatty liver remain poorly elucidated. The farnesoid X receptor () plays a critical role in the regulation of BA homeostasis. Consequently, the aim of this study was to investigate the effect of -mediated BA metabolism following stimulation with high concentrations of free fatty acids (FFA). - Source: PubMed
Publication date: 2026/04/30
Jia BinTian YanGao ChanghongChang YaqiZhang ZexinSong YuxiXia ChengQu YongliYang Wei