Ask about this productRelated genes to: NR5A1 Blocking Peptide
- Gene:
- NR5A1 NIH gene
- Name:
- nuclear receptor subfamily 5 group A member 1
- Previous symbol:
- FTZF1
- Synonyms:
- FTZ1, SF-1, ELP, AD4BP, hSF-1, SF1
- Chromosome:
- 9q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-06-07
- Date modifiied:
- 2018-02-14
Related products to: NR5A1 Blocking Peptide
Related articles to: NR5A1 Blocking Peptide
- High-grade serous ovarian cancer (HGSOC) is the most lethal ovarian cancer subtype, responsible for ~ 70% of ovarian cancer-related deaths and marked by late-stage diagnosis and frequent platinum resistance. Although transcriptomic profiling enables molecular stratification and prediction of therapeutic response; routine clinical use of this approach is limited by cost and logistical constraints. Computational pathology analysis offers a scalable alternative by inferring transcriptional states directly from routine hematoxylin and eosin (H&E) whole-slide images (WSIs). - Source: PubMed
Publication date: 2026/06/11
Lingasamy PrakashOstrowska-Leśko MartaTsakalis PantelisPatel NaisargChamatidis IliasSudhakaran Sajitha LuluKubik JoannaBobiński MarcinLagaros Nikos DSalumets AndresModhukur Vijayachitra - This study aimed to investigate the mechanisms underlying Nuclear Receptor Subfamily 5 Group A Member 1 (NR5A1, encoding SF-1) hypomethylation in endometriosis (EMs) and to evaluate the effects of Luoshi Neiyi Prescription (LSNYP) on NR5A1 methylation. - Source: PubMed
Publication date: 2026/06/11
Wu LizhengZheng KaidiZou YouRuan YuanyuanLi XiangJia JinjinLi ZhenzhenLin ShuhongZhong WeilanZeng ChengPei Fangli - NR5A1 encodes a transcription factor essential for adrenal and gonadal development. Gene variants are a known cause of heterogeneous 46,XY disorders of sex development (DSD), but the mechanisms underlying the phenotypic variability remain unclear. We investigated how different NR5A1 variants affect downstream gene regulation and contribute to DSD pathogenesis. - Source: PubMed
Publication date: 2026/06/09
Liu QingxuZang ShaolianLi YanYin XiaoqinLi Pin - The arcuate nucleus (ARC) and ventromedial hypothalamus (VMH) are highly specialized hypothalamic nuclei controlling appetite and energy expenditure. Here, we demonstrate that human VMH and ARC neurons can be generated from pluripotent stem cells by fine-tuned timing and duration of bone morphogenetic protein (BMP) exposure. We identified SHH/NKX2.1/FGF10/RAX/TBX3 posterior tuberal progenitors as the source of ARC cell types, including agouti-related peptide (AGRP)-, prepronociceptin (PNOC)-, growth-hormone-releasing hormone (GHRH)-, and thyrotropin-releasing hormone (TRH)-expressing neurons and β2-tanycytes. Differentiated ARC cultures showed high transcriptomic similarity to human ARC and responded to energy homeostasis-regulatory peptides including leptin, glucagon-like peptide 1 (GLP-1), ghrelin, and fibroblast growth factor 1 (FGF1). In contrast, anterior tuberal TBX3 progenitors generated VMH-associated neurons expressing NR5A1, SOX14, and GPR149. Strikingly, two transcriptionally distinct pro-opiomelanocortin (POMC) subpopulations emerged from these lineages, mapping spatially to either the ARC (POMC/TBX3/NR5A2) or the VMH (POMC/SOX14/NR5A1). This model provides a cellular platform to study human hypothalamic subtype specification and pathways involved in central appetite regulation. - Source: PubMed
Publication date: 2026/06/08
Abay-Nørgaard ZehraMueller Anika KHänninen ErnoRausch DylanPiilgaard LouiseTrujillo Lucía SenaFedrizzi LorenzoChristensen Jens BagerSalvador AlisonSchörling Alrik LMottelson Noah WulffQin QiuyuSampath ShruthiHersbach BobHenkenjohann JonasPeeters SofieNikulina ViktoriiaKruse Charlotte HøyLi YuanChinnaiya KavithaPlaczek MarysiaKajtez JankoPers Tune HKirkeby Agnete - The mouse adrenal gland is encapsulated by a mesenchymal cell layer (capsule) and contains an underlying cortex organized into distinct concentric zones with specialized endocrine functions: the zona glomerulosa (zG), which produces aldosterone, and the zona fasciculata (zF), which produces corticosterone. The adrenal medulla, located at the center of the gland, produces catecholamines. Mechanistic studies of cells from each adrenocortical zone have been limited by the absence of in vitro models that preserve their zone-specific molecular, cellular, and functional characteristics. To overcome this limitation, a fractionation approach was developed using microdissection of adult mouse adrenal glands. This method separates adrenal cells from male mice into a zG-enriched outer fraction (OF), containing capsule and zG cells, and a zF-enriched inner fraction (IF), which contains zF and medullary cells. These fractions were used to generate two-dimensional (2D) primary cultures enriched for either zG or zF cells. Gene expression analysis confirmed that the zG-enriched cultures express high levels of zG markers (Cyp11b2, Dab2, and Shh), along with increased Wnt/β-catenin pathway markers (Wnt4, Lef1). In contrast, zF-enriched cultures exhibited higher expression of zF markers (Cyp11b1 and Akr1b7) and lower levels of Wnt/β-catenin pathway markers, consistent with a zF transcriptional signature. Expression of steroidogenic markers (Nr5a1, Star) validated the adrenocortical origin of both cell fractions. Tyrosine hydroxylase indicates the presence of adrenal medullary cells in zF-enriched cultures. Functionally, zG-enriched cultures produced aldosterone under basal conditions and showed increased production in response to angiotensin II, potassium, and adrenocorticotropic hormone (ACTH). Conversely, zF-enriched cultures produced corticosterone at baseline and exhibited increased output in response to ACTH stimulation. Overall, this protocol represents a robust, reproducible, and biologically relevant in vitro model for studying adrenal cortex biology. This system enables zone-specific investigation of signaling pathways, molecular mechanisms, and physiological responses. - Source: PubMed
Publication date: 2026/05/08
Kremer Jean LucasBorges Kleiton SilvaRibeiro ClaudioBerber MesutHaykir BetulCarlone Diana LLotfi Claudimara Ferini PaciccoBreault David T