Ask about this productRelated genes to: C1QTNF7 Blocking Peptide
- Gene:
- C1QTNF7 NIH gene
- Name:
- C1q and TNF related 7
- Previous symbol:
- -
- Synonyms:
- CTRP7
- Chromosome:
- 4p15.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-02
- Date modifiied:
- 2017-03-01
Related products to: C1QTNF7 Blocking Peptide
Related articles to: C1QTNF7 Blocking Peptide
- Intertidal habitats present extreme environmental fluctuations, such as periodic air exposure that exposes aquatic organisms to desiccation, oxidative stress, and osmotic imbalance. Scartelaos histophorus, an amphibious fish, demonstrates exceptional physiological resilience in these dynamic ecosystems. This study investigates the physiological, histological, and transcriptomic responses of S. histophorus skin to varying durations of air exposure and subsequent aquatic recovery. Histological analyses indicate transient epidermal remodeling and markers of oxidative stress, reflecting reversible cellular damage. Antioxidant enzyme activities suggest compensatory protective mechanisms against oxidative challenges. Transcriptomic profiling identifies differentially expressed genes significantly enriched in pathways associated with keratinization, hypoxia response, vascular morphogenesis, and extracellular matrix remodeling, highlighting the molecular underpinnings of epidermal plasticity. Notably, the activation of the Peroxisome proliferator-activated receptors (PPARs) signaling pathway during air exposure, with with upregulation of c1qtnf7, indicating its involvement in lipid regulation and epidermal adaptation. These findings offer new insights into the molecular mechanisms underlying adaptation to air exposure in S. histophorus, enhancing our understanding of amphibious fish survival strategies in fluctuating environments. - Source: PubMed
Publication date: 2025/05/29
Xiao DongdongWang RuizhiZhang PeidongRiyanti Zhao LinlinSong Na - The incidence and mortality of cervical cancer remain high in female malignant tumors worldwide. There is still a lack of diagnostic and prognostic markers for cervical carcinoma. This study aimed to screen differentially expressed genes (DEGs) between normal and cervical cancer tissues to identify candidate genes for further research. - Source: PubMed
Publication date: 2024/10/02
Xu JiaYang WenXie XiufengGu ChengleiZhao LuyangLiu FengZhang NinaBai YugeLiu DanLiu HainanJin XiangshuMeng Yuanguang - To screen for the key characteristic genes of the psoriasis vulgaris (PV) patients with different Traditional Chinese Medicine (TCM) syndromes, including blood-heat syndrome (BHS), blood stasis syndrome (BSS), and blood-dryness syndrome (BDS), through bioinformatics and machine learning and to provide a scientific basis for the clinical diagnosis and treatment of PV of different TCM syndrome types. - Source: PubMed
Liu XueweiJia HuangchaoWang LiyunWang ZiwenXu MengyueLi YunfeiWang Ronghui - The large-conductance calcium-activated potassium (BK) channel is a critical regulator and potential therapeutic target of vascular tone and architecture, and abnormal expression or dysfunction of this channel is linked to many vascular diseases. Vascular remodelling is the early pathological basis of severe vascular diseases. Delaying the progression of vascular remodelling can reduce cardiovascular events, but the pathogenesis remains unclear. To clarify the role of BK channels in vascular remodelling, we use rats with BK channel α subunit knockout (BK α ). The results show that BK α rats have smaller inner and outer diameters, thickened aortic walls, increased fibrosis, and disordered elastic fibers of the aortas compared with WT rats. When the expression and function of BK α are inhibited in human umbilical arterial smooth muscle cells (HUASMCs), the expressions of matrix metalloproteinase 2 (MMP2), MMP9, and interleukin-6 are enhanced, while the expressions of smooth muscle cell contractile phenotype proteins are reduced. RNA sequencing, bioinformatics analysis and qPCR verification show that C1q/tumor necrosis factor-related protein 7 ( ) is the downstream target gene. Furthermore, except for that of MMPs, a similar pattern of IL-6, smooth muscle cell contractile phenotype proteins expression trend is observed after knockdown. Moreover, knockdown of both and in HUASMCs activates PI3K/Akt signaling. Additionally, CTRP7 is expressed in vascular smooth muscle cells (VSMCs), and BK α deficiency activates the PI3K/Akt pathway by reducing CTRP7 level. Therefore, we first show that BK channel deficiency leads to vascular remodelling. The BK channel and CTRP7 may serve as potential targets for the treatment of cardiovascular diseases. - Source: PubMed
Bi JingDuan YanruWang MeiliHe ChunyuLi XiaoyueZhang XiTao YanDu YunhuiLiu Huirong - Meat quality is highly influenced by the kind of muscle fiber, and it can be significantly improved by increasing the percentage of slow-twitch fibers. It is still not known which genes control the formation of muscle fibers or how those genes control the process of forming in sheep until now. In this study, we used high-throughput RNA sequencing to assess the expression profiles of coding and noncoding RNAs in muscle tissue of Tan sheep and Dorper sheep. To investigate the molecular processes involved in the formation of muscle fibers, we collected two different muscle tissues, and , from Tan sheep and Dorper sheep. The of Tan sheep and Dorper sheep displayed significantly differential expression levels for 214 lncRNAs, 25 mRNAs, 4 miRNAs, and 91 circRNAs. Similarly, 172 lncRNAs, 35 mRNAs, 12 miRNAs, and 95 circRNAs were differentially expressed in the of Tan sheep and Dorper sheep according to the expression profiling. GO and KEGG annotation revealed that these differentially expressed genes and noncoding RNAs were related to pathways of the formation of muscle fiber, such as the Ca, FoxO, and AMPK signaling pathways. Several key genes are involved in the formation of muscle fibers, including ACACB, ATP6V0A1, ASAH1, EFHB, MYL3, C1QTNF7, SFSWAP, and FBXL5. RT-qPCR verified that the expression patterns of randomly selected differentially expressed transcripts were highly consistent with those obtained by RNA sequencing. A total of 10 lncRNAs, 12 miRNAs, 20 circRNAs, and 19 genes formed lncRNA/circRNA-miRNA-gene networks, indicating that the formation of muscle fiber in Tan sheep is controlled by intricate regulatory networks of coding and noncoding genes. Our findings suggested that specific ceRNA subnetworks, such as circ_0017336-miR-23a-FBXL5, may be critical in the regulation of the development of muscle fibers, offering a valuable resource for future study of the development of muscle fibers in this animal species. The findings increase our understanding of the variety in how muscle fibers originate in various domestic animals and lay the groundwork for future research into new systems that regulate the development of muscle. - Source: PubMed
Publication date: 2022/10/18
Cui RanKang XiaolongLiu YufangLiu XimingChan ShuhengWang YubeiLi ZhenLing YaoFeng DengzhenLi MenghuaLv FenghuaFang Meiying