Ask about this productRelated genes to: PSG5 Blocking Peptide
- Gene:
- PSG5 NIH gene
- Name:
- pregnancy specific beta-1-glycoprotein 5
- Previous symbol:
- -
- Synonyms:
- FL-NCA-3, PSG
- Chromosome:
- 19q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-13
- Date modifiied:
- 2016-10-05
Related products to: PSG5 Blocking Peptide
Related articles to: PSG5 Blocking Peptide
- Saccharopolyspora erythraea is an industrially important actinobacteria and a model in polyketide biosynthesis studies. However, its genetic toolbox remains limited. Here, we evaluated the properties of integrative and replicative vectors in Sacch. erythraea DSM40517. Three actinophage-based integrative vectors (φC31, φBT1, VWB) were efficiently transferred into Sacch. erythraea. The attB sites for these vector systems were identified. In case of φBT1- and VWB-based vectors, unique integration sites exists within the chromosome of the strain. In case of pSET152 (φC31), at least four different loci were identified with different efficiency of recombination. Our data revealed that all three integrative vectors are excised from the chromosome of the strain with varying frequencies, highlighting the need for selective pressures for their stable maintenance. Commonly used replicative vectors with Streptomyces replicons (pIJ101 and pSG5) have low transfer efficiency in Sacch. erythraea. To solve this problem, we constructed a shuttle vector pYS191 based on the replicon of plasmid pJV1. This vector was efficiently transferred into Sacch. erythraea and other actinobacteria including Streptomyces, Saccharothrix and Couchioplanes species. pYS191 is maintained at a low copy number under selective conditions, and is rapidly lost without antibiotic pressure. Neither integrative nor replicative vectors significantly affected erythromycin production. This study provides a comprehensive assessment of vector system in Sacch. erythraea and reports a new replicative vector based on rarely exploited pJV1 replicon for transient gene expression and genome engineering. These results expand the genetic toolbox for Saccharopolyspora and facilitate its use in natural products research and industrial biotechnology. KEY POINTS: • Actinobacterial integrative vectors are suited for gene cloning in Sacch. erythraea. • attB sites for three integrative vectors identified within Sacch. erythraea genome. • A new replicative vector pYS191 for use in Sacch. erythraea was constructed. - Source: PubMed
Publication date: 2026/05/14
Nohach YanaSamborskyy MarkiyanPalusczak AnjaLuzhetskyy AndriyFedorenko VictorRebets Yuriy - To maximize the energy density output, the complementary charge storage mechanism of aqueous zinc ion hybrid capacitors (ZIHCs) is superior and advanced, but continuous water-induced side reactions and uncontrolled dendrite growth of zinc anodes remain challenging. Additionally, the optimization of the hydrogel electrolyte/electrode interface is necessary for the stability and kinetic reversibility of the flexible zinc-based energy storage device. Herein, the P(AM-SBMA) (copolymer of acrylamide AM and zwitterionic compound SBMA)/gelatin hydrogel electrolyte (PSG) with a special semi-interpenetrating network is designed based on the chain-chain synergistic regulation mechanism to regulate the desolvation of zinc ions and optimize the operating voltage of flexible ZIHCs and stabilize surface chemistry of zinc anode. The obtained PSG-5 hydrogel electrolyte widens the electrochemical stability windows (ESW) of the flexible ZIHC to 2.45 V and achieves high Zn transference number of 0.87 and highly reversible plating/stripping of the zinc anode. Furthermore, the corresponding flexible ZIHC exhibits a high operating voltage of 2.2 V and provides a favorable energy density of 117 Wh kg at a power density of 293 W kg. This work provides useful insights for the development of efficient, flexible ZIHCs by preparing hydrogel electrolytes capable of stabilizing zinc anodes and widening ESW. - Source: PubMed
Publication date: 2025/06/10
Zhang HangWan LiYou ZiranLiang JianrongLei DaCui Yongyan - Liver cirrhosis, a common liver disease, currently lacks specific targeted therapies. This study investigates the potential therapeutic effects of serum circulating proteins on cirrhosis from a genetic perspective, and identified six associated plasma proteins (SERPINA1, PSG5, NCAN, APOE, ADH1B, GM2A). To search for therapeutic drugs associated with circulating proteins, databases such as DrugBank and DGIdb are utilized. Phenome-wide Mendelian Randomization analysis of the six significantly associated proteins revealed that GM2A exhibited no notable side effects as a therapeutic target for cirrhosis, SERPINA1 may offer additional therapeutic benefits for cholelithiasis and emphysema. ADH1B serves as a potential drug target that could simultaneously reduce the risk of alcohol-related disorders and hypertension. Furthermore, PSG5 and APOE might increase the risk of cardiovascular and neurological diseases, and NCAN has the potential to additionally reduce the risk of developing non-alcoholic fatty liver disease NAFLD. In conclusions, this study substantiates, from a genetic perspective, the potential therapeutic target role of six plasma proteins in cirrhosis, while comprehensively evaluating their side effects. - Source: PubMed
Publication date: 2024/11/21
Xiao Qing-AoZhao Wen-JiangYu JingQin LeiZhang Xiao-LinYu Jin - Endometrial cancer (EC) as one of the most common gynecologic malignancies is increasing in incidence during the past 10 years. Genome-Wide Association Studies (GWAS) extended to metabolic and protein phenotypes inspired us to employ multiomics methods to analyze the causal relationships of plasma metabolites and proteins with EC to advance our understanding of EC biology and pave the way for more targeted approaches to its diagnosis and treatment by comparing the molecular profiles of different EC subtypes. - Source: PubMed
Publication date: 2024/09/01
Shen YufeiTian YanDing JiashanChen ZhuoZhao RongLu YingnanLi LuciaZhang HuiWu HaiyueLi XiZhang Yu - The SUV is a measure of FDG uptake and is related with tumor aggressiveness in thyroid cancer, however, its association with molecular pathways is unclear. Here, we investigated the relationship between SUV and gene expression profiles in 80 papillary thyroid cancer (PTC) patients. We conducted an analysis of DEGs and enriched pathways in relation to SUV and tumor size. SUV showed a positive correlation with tumor size and correlated with glucose metabolic process. The genes that indicate thyroid differentiation, such as SLC5A5 and TPO, were negatively correlated with SUV. Unsupervised analysis revealed that SUV positively correlated with DNA replication(r = 0.29, p = 0.009), pyrimidine metabolism(r = 0.50, p < 0.0001) and purine metabolism (r = 0.42, p = 0.0001). Based on subgroups analysis, we identified that PSG5, TFF3, SOX2, SL5A5, SLC5A7, HOXD10, FER1L6, and IFNA1 genes were found to be significantly associated with tumor aggressiveness. Both high SUV PTMC and macro-PTC are enriched in pathways of DNA replication and cell cycle, however, gene sets for purine metabolic pathways are enriched only in high SUV macro-PTC but not in high SUV PTMC. Our findings demonstrate the molecular characteristics of high SUV tumor and metabolism involved in tumor growth in differentiated thyroid cancer. - Source: PubMed
Publication date: 2024/05/14
Ju Sang-HyeonLee Seong EunYi ShinaeChoi Na RaeKim Kun HoKim Seong MinKoh June-YoungKim Seon-KyuKim Seon-YoungHeo Jun YoungPark Junyoung OPark SeongyeolKoo Bon SeokKang Yea Eun