Ask about this productRelated genes to: VEGFA Blocking Peptide
- Gene:
- VEGFA NIH gene
- Name:
- vascular endothelial growth factor A
- Previous symbol:
- VEGF
- Synonyms:
- VEGF-A, VPF
- Chromosome:
- 6p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-01-10
- Date modifiied:
- 2016-10-05
Related products to: VEGFA Blocking Peptide
Related articles to: VEGFA Blocking Peptide
- To characterize the aqueous humor (AH) cytokine profiles across clinical subtypes of congenital cataracts with posterior polar abnormality (PPA) and to assess their associations with postoperative complications. - Source: PubMed
Zhang QingruoQiu XinyiChung Ka YiZhang JunlinLin ZhuolingLin XiaoshanLin YongbinChen WeirongChen Hui - This study integrated network pharmacology, bioinformatics, and experimental validation to investigate the glycolysis-related targets of Yanghe Pingchuan granule (YPG) in asthma therapy. Active ingredients of YPG were screened via TCMSP, with targets identified through UniProt. Asthma-associated differentially expressed genes (DEGs) were extracted from GEO datasets, whereas asthma- and glycolysis-related targets were mined from GeneCards, OMIM, TTD, DrugBank and MSigDB. Venn analysis identified three key genes (GSTP1, VEGFA and HIF1A) linked to HIF-1 and VEGF signalling pathways. Molecular docking confirmed strong binding between core YPG compounds (quercetin, kaempferol and luteolin) and these targets. ROC analysis demonstrated high diagnostic value of VEGFA and HIF1A for asthma. In vivo validation showed that YPG significantly downregulated GSTP1, VEGFA and HIF1A expression in asthmatic rats. Our findings establish VEGFA and HIF1A as pivotal glycolysis-associated targets in asthma, indicating that YPG exerts anti-asthma effects by modulating these critical regulators. - Source: PubMed
Zhang QiupingZhu HuizhiXia YongqiLv Chuan - Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, microvascular dysfunction, and low-grade inflammation. Although low-carbohydrate, high-fat (LCHF) dietary approaches are increasingly used in clinical practice, their longer-term associations with vascular, lymphatic, and immunometabolic pathways in lipedema remain insufficiently understood. This preliminary exploratory study evaluated clinical outcomes and circulating mediators during a 7-month LCHF dietary intervention. Twenty-four women with lipedema (median age: 39 years) underwent a 7-month individualized, calorie-restricted LCHF diet under medical supervision. Outcomes included body mass index (BMI), leg volume, and adipose tissue pain assessed using a visual analogue scale (VAS). Fasting serum samples collected at baseline and follow-up were analyzed for angiogenic, inflammatory, endothelial, and lipid mediators using Luminex assays and liquid chromatography-tandem mass spectrometry (LC-MS/MS). The intervention was associated with significant reductions in BMI, leg volume, and adipose tissue pain ( < 0.001). These changes were accompanied by increased vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor D (VEGF-D), and angiopoietin-2 (Ang-2), together with decreased pro-inflammatory cytokines and endothelial adhesion molecules. Several endocannabinoid-related lipid mediators, including oleoyl ethanolamide (OEA), arachidonoyl ethanolamide (AEA), and palmitoyl ethanolamide (PEA), also decreased. Baseline OEA and AEA concentrations, as well as reductions in OEA over time, were associated with greater BMI reduction. Change in interleukin-8 (IL-8) showed a nominal association with leg volume reduction, while pain improvement was associated with decreases in P-selectin and VEGF-A and increases in interleukin-13 (IL-13). A 7-month calorie-restricted LCHF dietary intervention in women with lipedema was associated with clinical improvement and changes in circulating vascular, inflammatory, and lipid mediators. These findings reflect systemic changes accompanying the intervention; however, causal relationships and specific mechanisms cannot be established. - Source: PubMed
Publication date: 2026/04/28
Chachaj AngelikaFleszar MariuszLewandowski ŁukaszFortuna PaulinaMaciejewska GabrielaSowicz MonikaAdaszyńska AgnieszkaJakobsche-Policht UrszulaKrzystek-Korpacka MałgorzataSzuba AndrzejJeziorek Małgorzata - The kidney and the brain share similarities in terms of structure and haemodynamic regime. The aim of the study was to assess a potential correlation of vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor-1 (sFlt-1), and placental growth factor (PlGF) with biomarkers of podocyte damage, proximal tubular (PT) dysfunction, and endothelial dysfunction, as well as with cerebral vessels haemodynamic indices in neurologic asymptomatic type 2 DM patients. A cohort of 212 patients diagnosed with type 2 DM and 49 age- and gender-matched healthy controls were enrolled in the study. Parameters studied were urinary albumin/creatinine ratio (UACR), biomarkers of podocyte damage (synaptopodin, podocalyxin), PT dysfunction (kidney injury molecule-1-KIM-1, N-acetyl-β-(D)-glucosaminidase-NAG), endothelial dysfunction (P-selectin), VEGF, sFlt-1, and PlGF. The cerebrovascular hemodynamic indices evaluated were intima-media thickness (IMT) in the common carotid arteries (CCAs), the pulsatility index (PI), and the resistivity index (RI) in the internal carotid arteries (ICAs) and middle cerebral arteries (MCAs). Cerebrovascular reactivity (CVR) was assessed by the breath-holding index (BHI). In multivariable regression analysis, serum VEGF correlated directly with UACR, synaptopodin, NAG, serum P-selectin; serum sFlt-1 correlated directly with UACR, synaptopodin, podocalyxin, NAG, KIM-1; serum PlGF correlated negatively with eGFR and directly with UACR, synaptopodin, KIM-1. IMT-CCA correlated indirectly with eGFR and directly with UACR, serum P-selectin, and serum sFlt-1. The PI-ICAs correlated negatively with eGFR and positively with UACR, synaptopodin, serum P-selectin, and serum sFlt-1. The PI-MCAs correlated indirectly with eGFR and directly with synaptopodin, serum P-selectin, and serum sFlt-1. The RI-ICAs had a negative correlation with eGFR and a positive one with UACR, synaptopodin, NAG, KIM-1, urinary sFlt-1, and serum PlGF. The RI-MCAs displayed an indirect correlation with eGFR and a direct correlation with NAG, KIM-1, and serum sFlt-1. The BHT correlated directly with eGFR and negatively with serum P-selectin and serum PlGF. The study shows a significant association of VEGF, sFlt-1, and PlGF with biomarkers of podocyte injury, PT dysfunction, and endothelial dysfunction in early stages of DKD. These pro-angiogenic and anti-angiogenic factors correlated with cerebrovascular haemodynamic indices in neurologic asymptomatic type 2 DM, even in the normoalbuminuric stage of diabetic kidney disease. - Source: PubMed
Publication date: 2026/04/23
Petrica LigiaGadalean FloricaVlad AdrianVlad DaliborcaDumitrascu VictorPaul TutacBob FlaviuMilas OanaSuteanu-Simulescu AncaGlavan MihaelaUrsoniu SorinBalint-Marcu LaviniaMogos-Stefan MariaIenciu SilviaCretu Octavian MariusPopescu RoxanaGluhovschi CristinaIancu LaviniaJianu Dragos Catalin - Long non-coding RNAs (lncRNAs) regulate granulosa cell function, but their stage-specific dynamics across the chicken follicle hierarchy remain unclear under matched endocrine conditions. We performed Ribo-Zero RNA sequencing on granulosa cells from small yellow follicles (SYF), F5, F2, and F1 follicles collected at the preovulatory luteinizing hormone (LH) surge. A multi-predictor pipeline (CPC2, CNCI, CPAT, PfamScan) identified 26,923 stringently filtered lncRNAs together with 15,838 mRNAs. Consecutive stage comparisons detected 2094, 1085, and 4318 differentially expressed genes and 671, 267, and 2762 differentially expressed lncRNAs in F5 vs. SYF, F2 vs. F5, and F1 vs. F2, respectively, with the most extensive remodeling at the F2-to-F1 transition. The F1 vs. SYF contrast captured the cumulative transcriptional difference across the hierarchy. Enrichment and temporal clustering showed that early hierarchical stages were characterized by proliferative, metabolic, and steroidogenic programs, whereas F1 granulosa cells were enriched for extracellular-matrix remodeling, MAPK signaling, and calcium ion binding. Weighted gene co-expression network analysis identified 10 stage-associated modules and highlighted candidate lncRNAs linked to lipid metabolism, angiogenesis, extracellular-matrix remodeling, and DNA repair, including -, -, and -. qPCR validation confirmed concordant expression trends for eight representative pairs. These results define a stage-resolved lncRNA-mRNA landscape across chicken follicle development and provide candidates for mechanistic studies of follicle maturation and periovulatory remodeling. - Source: PubMed
Publication date: 2026/04/28
Li LiangHan XueTan LulinTan YaZhu LiliLi YilongLuo LinWu Jiahai