Ask about this productRelated genes to: Slc9a5 Blocking Peptide
- Gene:
- SLC9A5 NIH gene
- Name:
- solute carrier family 9 member A5
- Previous symbol:
- -
- Synonyms:
- NHE5
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-21
- Date modifiied:
- 2016-02-25
Related products to: Slc9a5 Blocking Peptide
Related articles to: Slc9a5 Blocking Peptide
- In this study, we aimed to elucidate the functional significance of transforming growth factor-β (TGF-β)-regulated SLC9A5 (NHE5) in enamel formation. - Source: PubMed
Publication date: 2025/12/04
Takano HayatoChiba-Ohkuma RisakoKobayashi SaekoYamamoto RyujiKataoka ReiMiyakawa YuriAsada YoshinobuYamakoshi Yasuo - Diabetic kidney disease (DKD) is a major microvascular complication of diabetes, characterized by abnormal mesangial cell (MC) proliferation, yet the underlying mechanisms remain unclear. - Source: PubMed
Publication date: 2026/02/02
Wang QijiaChong XinyuLiu HandengPeng RuiPeng XuemeiLiao XiaohuiSun YanZhang Zheng - Egg-laying performance in chickens is primarily dependent on the normal development and maturation of follicles, which are regulated by various functional genes. However, the functional genes that regulate follicular development are not fully known. Here, we utilized RNA sequencing (RNA-seq) technology and bioinformatics analysis to identify the potential genes involved in the modulation of granulosa cells (GCs) from small yellow follicles (SYFG, 4-8 mm in diameter), the smallest hierarchical follicle (F6G, 9-12 mm in diameter) and the largest hierarchical follicle (F1G, ∼40 mm in diameter). Furthermore, association analysis was performed between polymorphisms of the identified candidate RMDN2 and egg production performance. Transcriptome analysis revealed 284 and 1026 differentially expressed genes (DEGs) in SYFG.vs.F6G and F6G.vs.F1G under the condition of |log fold change| > 1 and q-value < 0.01, respectively. Among these, 107 DEGs were consistently detected in both SYFG.vs.F6G and F6G.vs.F1G comparisons. These 107 DEGs were primarily enriched in the PPAR signalling pathway, thyroid hormone synthesis, and steroid biosynthesis pathways. Notably, 41 of these DEGs have been strongly linked to reproductive processes in previous studies. qRT-PCR validation validated that 13 genes (UTRN, LOC422926, MYH11, CD9, TIGAR, RARA, PLBD1, PPP1CB, RMDN2, SORCS2, SLC9A5, PDLIM4 and PPP4R4) exhibited similar expression trends in GCs across three stages in G1 layer line. Correlation analysis uncovered that RMND2 expression was negatively associated with the differentiation markers of FSHR and AMH, as well as the proliferation markers of CDK2, but positively correlated with the steroidogenesis markers of CYP11A1, STAR, and ESR1. Analysis of polymorphisms in the RMDN2 gene indicated that c.250G > A (SNP1) and c.270G > C (SNP2) were significantly associated with the egg number at 40-week-old (EN40, p < 0.05) in G1 layer line hens. The haplotype combination H1H2 exhibited the highest EN40. In summary, this study identified functional genes associated with GC development in chickens and highlighted RMDN2 polymorphisms as potential markers for laying traits selection in chickens. - Source: PubMed
Publication date: 2025/11/29
Li AshiLiao YuechenLi DehuiLi TaoLuo YangqiwenMa MengWang XingguoSun LiumeiQu LiangShen Manman - Growing evidence suggests a strong association between decreased lipid catabolism and the development of cancer. Solute carrier family 9 member A5 (SLC9A5) plays a regulatory role in colorectal function. However, the specific involvement of SLC9A5 in colorectal cancer (CRC) remains unclear, as well as its potential connection to lipid catabolism. We found that SLC9A5 exhibited significantly higher expression in CRC tumor tissues compared to adjacent paratumor tissues, as confirmed through analysis of the TCGA database and validation on a CRC tissue chip using IHC. Furthermore, in vitro experiments showed that knockdown of SLC9A5 resulted in suppressed cell proliferation, migration, and invasion. Then we performed bioinformatics analysis and found that SLC9A5 was significantly enriched in peroxisomal fatty acid oxidation (FAO) pathway and negatively correlated with its first rate-limiting enzyme acyl-CoA oxidases (ACOX). Interestingly, the expression of ACOX1, as well as FAO process indicated by changes in very long chain fatty acid levels, were enhanced upon SLC9A5 knockdown in CRC cells. Moreover, the attenuated tumor growth, migration, invasion, and increased FAO observed after SLC9A5 knockdown could be reversed by simultaneous knockdown of both SLC9A5 and ACOX1. In summary, these findings reveal the oncogenic role of SLC9A5 in CRC, particularly in relation to ACOX1-mediated peroxidation, and might serve as a promising therapeutic target for inhibiting the progression of colorectal cancer. - Source: PubMed
Publication date: 2023/06/26
Zheng RuipanWang Yurong - The acidic characteristics of the tumor microenvironment (TME) are attributed to cancer cells' needs of metabolism which produce a large amount of H. In order not to affect its own life activities, it needs to release H into the intercellular space through an efficient Na/H exchanger. On account of the intestine whose physiological function is highly dependent on intestinal pH value, NHE family members may play a critical role in the occurrence and development of colorectal cancer (CRC). - Source: PubMed
Publication date: 2021/11/01
Zhou XinJiang ManmanLiu ZhihongXu MengmengChen NannanWu ZiyuGu ChangjiChin EugeneYang Xiaodong