Ask about this productRelated genes to: HP1BP3 Blocking Peptide
- Gene:
- HP1BP3 NIH gene
- Name:
- heterochromatin protein 1 binding protein 3
- Previous symbol:
- -
- Synonyms:
- HP1-BP74
- Chromosome:
- 1p36.12
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-16
- Date modifiied:
- 2016-02-23
Related products to: HP1BP3 Blocking Peptide
Related articles to: HP1BP3 Blocking Peptide
- Major depressive disorder (MDD) is a debilitating mental illness influenced by genetic and environmental factors. This study aimed to investigate the hypoxia-related differentially expressed genes (HRDEGs) associated with MDD, which remain unknown, construct a diagnostic model, and analyze immune infiltration. - Source: PubMed
Publication date: 2025/08/19
Pan RuyueYang YanKong QinghuoYu JieChen Jiaxu - The anterior insular cortex (aIC) is involved in multiple neuropsychiatric disorders. Here, using the Cntnap2-deficient autism spectrum disorder (ASD) mouse model and the chronic social defect stress (CSDS)-induced depression mouse model, we show that two subpopulations of microglia in the mouse aIC played differential roles in ASD-like and depression-like behavioral phenotypes differentially. The Cx3cr1 microglia had morphological deficits in the Cntnap2-deficient mice and were involved in social deficits and restricted repetitive behaviors, while the Tmem119 microglia had morphological deficits in the CSDS-induced mice and contributed to impairments in sucrose preference and forced swim performance. Further, we showed that the two subsets of microglia had differential features in morphology, transcriptional profiles, electrophysiological properties, and impacts on synaptic functions. Using proteomic and metabonomic analyses, we identified two secretory factors, Fbl and Hp1bp3, that were crucial for the dysfunctions of the Cx3cr1 and Tmem119 microglia, respectively. Finally, we verified that Fbl and Hp1bp3 played essential roles in the behavioral deficits of the Cntnap2-deficient and the CSDS-induced mice, respectively. Our study can help understand the contribution of microglia and the aIC to neuropsychiatric-like behaviors. - Source: PubMed
Publication date: 2025/08/06
Zhang Qiao-MingChen Yan-FenXing Yun-YunYang MengliuLi NaJiang XiGao HongyanLu Si-YaoYao Jun - Prostate cancer (PCa) is a common malignancy with a "cold" tumor microenvironment (TME) that limits immunotherapy efficacy. Neoantigens from non-synonymous mutations are potential immunotherapeutic targets. - Source: PubMed
Publication date: 2025/07/25
Wang JianiGuo RuiZhang LuyaoZuo WenLi XuanZhang ShaTan QinMa Jie - Postpartum mood and anxiety disorders (PMADs) are higher among pregnant military service women (26%) and military spouses (12.2%) compared to the civilian population (10%-15%). This is partly due to military-specific factors, including deployment, which are known to increase risk. Important risk factors for PMADs include sleep disturbances, defined as sleep deprivation, insomnia, or poor sleep quality, which are more are common among military-affiliated pregnant women. - Source: PubMed
Publication date: 2025/04/10
Okun Michele LPayne Jennifer LOsborne Lauren MFeliciano LeilaniLac Andrew - Linker histones constitute a class of proteins that are responsible for the formation of higher-order chromatin structures. Core histones are integral components of nucleosome core particles (NCPs), whereas linker histones bind to linker DNA between NCPs. Heterochromatin protein 1 binding protein 3 (HP1BP3) displays sequence similarity to linker histones, with the exception of the presence of three globular domains in its central region. However, the function of HP1BP3 as a linker histone has not been analyzed previously. The present study aimed to elucidate the function of full-length HP1BP3 as a linker histone variant. - Source: PubMed
Publication date: 2025/03/27
Hisaoka MiharuKomatsu TetsuroHashimoto TakumaLin JianhuangOhkawa YasuyukiOkuwaki Mitsuru