Ask about this productRelated genes to: TRIML2 Blocking Peptide
- Gene:
- TRIML2 NIH gene
- Name:
- tripartite motif family like 2
- Previous symbol:
- -
- Synonyms:
- FLJ25801, SPRYD6
- Chromosome:
- 4q35.2
- Locus Type:
- gene with protein product
- Date approved:
- 2007-12-14
- Date modifiied:
- 2015-11-13
Related products to: TRIML2 Blocking Peptide
Related articles to: TRIML2 Blocking Peptide
- Metastatic triple-negative breast cancer (TNBC) is highly aggressive and lacks targeted therapies. Circulating tumor cells (CTC) are invaluable for monitoring metastatic tumor progression and treatment response but are difficult to capture because of their rarity and heterogeneity. Surface-based staining for live CTCs is essential to preserve RNA quality in single cells, but current markers tend to perform poorly on more mesenchymal tumor cells such as TNBCs. To enhance live TNBC CTC detection, we developed a workflow for live CTC capture and single-cell RNA sequencing (scRNA-seq). Using a mouse model of metastatic TNBC, we identified four new CTC surface markers, AHNAK2, CAVIN1, ODR4, and TRIML2, which specifically stain tumor cells. Combining antibodies against these markers improved CTC detection rates in multiple TNBC mouse models and patient samples. Also, combining these new markers with traditional CTC surface markers enhanced detection sensitivity, achieving the highest CTC coverage. This approach identifies diverse CTC populations, while preserving RNA quality for scRNA-seq, which is essential for understanding and therapeutically targeting metastatic breast cancer. The use of these newly identified CTC markers significantly enhances both detection and live capture of CTCs, paving the way for more effective use of liquid biopsy to monitor patient prognosis and treatment response in clinical settings. - Source: PubMed
Lege Bree MPatel Khushali JPanici BrendanGong PingLewis Michael TEllis Matthew JCheng Chonghui - The roles and underlying mechanisms of tripartite motif family like 2 (TRIML2) in tumors, including head and neck squamous cell carcinoma (HNSC), remain poorly characterized. This study aimed to comprehensively characterize the significance of TRIML2 in HNSC using multi-omics analyses and experimental validation. - Source: PubMed
Publication date: 2025/11/13
Luo XiZhang YangWang YingjianWang HuikeXin DaoGuan LuluWang ZheWang PeiWang Feng - Gastric cancer is a common malignant tumor characterized by poor prognosis and limited therapeutic options. The combination of Regulated cell death inducers and enhancement of the immune therapeutic effect plays an important role in cancer treatment. - Source: PubMed
Publication date: 2025/09/10
Chen ShaofeiWang Zhiyong - As a key protein, Tripartite motif family-like 2 (TRIML2) is crucial to the p53-mediated apoptosis and is correlated with tumorigenesis. Emerging evidence showed that long non-coding RNAs (lncRNAs) play roles in the malignant progression of gastric cancer (GC). However, the function and underlying mechanism of LINC02679 in GC are still unclear. In this study, we detected the differentially expressed lncRNA, LINC02679, which was associated with the progression of GC. Herein, we showed that LINC02679 was overexpressed in GC tissues and correlated with poor prognosis, which aggravated GC proliferation, migration, and invasion. Mechanistically, LINC02679 sponged miR-5004-3p to promote the expression of TRIML2, regulating GC tumorigenesis and progression. Moreover, TRIML2 affected the proliferation, migration, and invasion of GC cells through TGF-β1/Smads signaling pathway. Overall, our findings proved a new mechanism and provided a promising strategy for precise therapy of GC by targeting LINC02679. - Source: PubMed
Publication date: 2025/04/01
Wang YingyingLiu WenboZhao XiaohanLi YongSong ChaoHuo BingjieSong YanruTan Bibo - The eutherian placenta is highly complex, evolving to regulate the inflammatory phase of pregnancy during conceptus attachment and placental tissue development. Tripartite motif family-like (TRIMLs) proteins are implicated in downregulating inflammation. In mammals, TRIML1 and TRIML2 show preferential expression in gonads, preimplantation embryos and placenta. TRIML1 domains differ between eutherians and marsupials, while TRIML2 is absent in marsupials, suggesting it may play a unique role in regulating the inflammatory phase during conceptus attachment, critical for establishing and maintaining pregnancy to term. This study aimed to investigate the expression pattern of TRIML1 and TRIML2 in various tissues, as well as during embryo development, conceptus attachment, and placental formation in pigs. Transcripts for TRIML2 were detected in embryos, conceptuses, extraembryonic membranes, ovary and testis but not in any of the other tissues examined. In contrast, TRIML1 expression was only observed in testis. In situ hybridization of TRIML1 and TRIML2 confirmed these results. The specific expression of TRIML2 in immune privileged sites is consistent with it serving as an anti-inflammatory factor to provide immunological protection of the eutherian placenta. To further investigate the role of TRIML2, CRISPR/Cas9 gene editing was employed to knock out either TRIML1 (control) or TRIML2. TRIML1 -/- and TRIML2 -/- porcine fetal fibroblasts were used for somatic cell nuclear transfer, and the resulting embryos were transferred into surrogate gilts. Early conceptus and placental development were not affected by the loss of conceptus TRIML2. Although a tissue-specific expression pattern was found, TRIML1 or TRIML2 are not required for pregnancy establishment in the pig. - Source: PubMed
Publication date: 2025/04/08
Eitel Emily KSponchiado MarianaSullivan Riley MLucas Caroline GRedel Bethany KChen Paula RWells Kevin DPrather Randall SWarren Wesley CGeisert Rodney D