Ask about this productRelated genes to: STAMBP Blocking Peptide
- Gene:
- STAMBP NIH gene
- Name:
- STAM binding protein
- Previous symbol:
- -
- Synonyms:
- AMSH
- Chromosome:
- 2p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-04
- Date modifiied:
- 2016-10-05
Related products to: STAMBP Blocking Peptide
Related articles to: STAMBP Blocking Peptide
- Delayed Cognitive Impairment (DCIS) occurs in approximately 31% to 77% of individuals following stroke. Clinical findings have indicated that electroacupuncture may alleviate post-stroke DCIS. However, insights derived from animal models remain limited. The present study utilized a Distal Middle Cerebral Artery Occlusion (DMCAO) mouse model to investigate the potential mechanisms of electroacupuncture through hippocampal transcriptomic analysis. - Source: PubMed
Publication date: 2026/03/13
Lu LiyueSong WeiLi ShichunXie ChenlongCui HuashunSong JiangangWang YongqiangYong Yue - Previous investigations have shown that the absence of typical breast symptoms is associated with unfavorable outcomes after an acute myocardial infarction (AMI). Delayed diagnosis and therapy could not explain these results, so other causes seem to be involved. Therefore, in the present analysis the association between inflammatory plasma proteins and typical chest pain symptoms in hospitalized patients with acute ST-elevation myocardial infarction (STEMI) was investigated. - Source: PubMed
Publication date: 2026/03/11
Wolfermann SophiaSchmitz TimoRaake PhilipLinseisen JakobMeisinger Christa - Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer that is usually diagnosed at a late stage and has a modest clinical response and poor prognosis. Therefore, identifying targets for the effective treatment of PDAC is particularly important. STAM-binding protein (STAMBP) is a JAMM metalloprotease of the deubiquitinase (DUB) family that typically regulates the stabilization and trafficking of substrates in a range of cell types by specifically removing ubiquitin chains. However, its roles in the initiation and progression of PDAC remain unclear. Here, we found that STAMBP is highly expressed in PDAC and is associated with a poor prognosis. STAMBP facilitates the proliferation and migration of PDAC cells and the growth of pancreatic cancer xenograft tumours in mice. We then identified the cochaperone BAG3, which plays a pivotal role in tumourigenesis, as a potential substrate of STAMBP using mass spectrometry (MS). Mechanistically, STAMBP interacts with BAG3 and promotes its stabilization by removing its K63-linked polyubiquitin chains. The Lys29 and Lys60 residues of BAG3 are essential for the K63-linked ubiquitination of BAG3. Moreover, a phosphorylation-dependent mechanism of STAMBP was identified as follows: STAMBP is phosphorylated by IKKα at Ser2 without affecting STAMBP protein abundance, and this phosphorylation enables it to deubiquitinate BAG3. In addition, we found that STAMBP deficiency effectively increases cisplatin/oxaliplatin sensitivity in PDAC. Overall, IKKα phosphorylates STAMBP at Ser 2, which activates STAMBP to deubiquitinase BAG3, thus resulting in an IKKα/STAMBP/BAG3 signaling axis that promotes PDAC progression. STAMBP might serve as a potential therapeutic target for PDAC therapy. - Source: PubMed
Publication date: 2026/01/29
Shi YongkangGong JunChen LinZhou MinPan ShutaoYin TaoyuanZhao ChunleLiu YuhuiZhang ZhenxiongBai YuLiao YangweiXia QilongWang MinQin Renyi - Biallelic variants in the STAMBP gene are known to cause Microcephaly-capillary malformation syndrome (MICCAP syndrome). Here we report an 18-month-old female with a novel splice site variant, c.376-1G>A in intron-4, with the phenotype of a patient who presented to us with fetal onset growth retardation, developmental delay, drug-resistant seizures, multiple capillary malformations, dysmorphism, tone abnormalities, and distal skeletal and nail abnormalities. Functional studies by RNA analysis and quantitative polymerase chain reaction (qPCR) showed that the variant leads to loss of function. The clinical features noted in this child strongly overlapped with the phenotypes reported in the literature, except for absent dentition and retinal dystrophy-like findings on fundus examination. A total of 22 cases have been reported in the literature. We present a detailed description of an Indian child, expanding the clinical and molecular spectrum of STAMBP-related disease. - Source: PubMed
Publication date: 2026/01/28
Gowda Vykuntaraju KRoy AmareshDisha BGovindaraj PeriyasamySrinivasan Varunvenkat M - Colorectal cancer (CRC) is one of the three leading causes of tumor-related mortality worldwide. The recruitment of bone marrow-derived suppressor cells (MDSCs) is a key mechanism by which tumors evade immune surveillance, as these cells inhibit T cell activity and accelerate CRC progression. STAMBP, a member of the Jab1/MPN metalloenzyme family of deubiquitinases (DUBs), cleaves K63-linked polyubiquitin chains from protein substrates and participates in diverse physiological and pathological processes. Nevertheless, its role in CRC and the mechanisms through which it contributes to disease progression have not been clearly defined. In the present study, we observed that both STAMBP and MDSCs were significantly upregulated in CRC tissues and cell lines. Functional assays revealed that STAMBP promotes CRC cell proliferation while simultaneously enhancing MDSC recruitment. Mechanistic analysis demonstrated that STAMBP regulates the deubiquitination of CXCR4, which stabilizes its protein expression. Silencing of CXCR4 not only suppressed CRC cell growth but also diminished MDSC infiltration. In conclusion, these findings indicate that STAMBP facilitates CRC progression through CXCR4 stabilization and MDSCs recruitment, highlighting a potential target for therapeutic intervention. - Source: PubMed
Publication date: 2026/01/20
Yang YangZhao SongJing FengXiong ZihanLi MeiXia Jing