Ask about this productRelated genes to: SLC41A2 Blocking Peptide
- Gene:
- SLC41A2 NIH gene
- Name:
- solute carrier family 41 member 2
- Previous symbol:
- -
- Synonyms:
- DKFZP434K0427
- Chromosome:
- 12q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-11
- Date modifiied:
- 2016-10-05
Related products to: SLC41A2 Blocking Peptide
Related articles to: SLC41A2 Blocking Peptide
- Magnesium ion (Mg), particularly its free intracellular form, is indispensable for regulating diverse cellular functions. This critical role implies the existence of dedicated transporters and channels in the plasma membrane that coordinate Mg uptake, intracellular storage, and efflux to maintain homeostasis. Although numerous molecular entities responsible for such Mg transport have been reported over the past decades, there is still limited knowledge of their precise functions and disease implications. This review focuses on the solute carrier family 41 (SLC41), which consists of three isoforms (A1, A2, and A3) that share homology with the prokaryotic magnesium transporter E (MgtE) Mg transporter family. Accumulating evidence has established SLC41A1 as the Na/Mg exchanger-a predominant Mg-efflux system. By contrast, the subcellular site of SLC41A2-mediated Mg flux remains undefined, with potential roles at either the plasma membrane or organellar membranes, and SLC41A3 facilitates Na-dependent Mg efflux from mitochondria. Additionally, several studies have reported the association between SLC41s and diseases, including Parkinson's disease, hepatocellular carcinoma, and nephronophthisis-related ciliopathies. By synthesizing current knowledge, this review aims to enhance the understanding of SLC41 transporters in health and disease and to explore their potential as therapeutic targets for clinical intervention. - Source: PubMed
Publication date: 2026/02/09
Cao YuRao CaijunDu Zhipeng - Colon cancer is a highly prevalent tumor with a high mortality rate worldwide. SLC41A2 is a member of the solute carrier family, but its role in colon cancer is still unclear. - Source: PubMed
Publication date: 2025/07/07
Lu YueyaoShen YingLiu JinsongDeng JianzhongWang YueLiu QianLu Wenbin - Hepatitis B virus (HBV) infection has been causally linked to hepatocellular carcinoma (HCC) in more than 50% cases. MicroRNAs (miRNAs) play cross-cutting mechanistic roles in the complex interplay between viral pathogenesis, host survival, and clinical outcomes. The present study set out to identify etiologically significant human miRNAs associated with HBV infection in liver-related pathologies leading to HCC. In diverse tissue types, we assembled 573 miRNAs differentially expressed in HBV-associated liver pathologies, HBV infection, fibrosis, cirrhosis, acute on chronic liver failure, and HCC. Importantly, 43 human differentially expressed miRNAs (hDEmiRs) were regulated in serum/plasma and liver tissue of patients with HBV-positive conditions. However, only two hDEmiRs, hsa-miR-21-5p and hsa-miR-143-3p, were regulated across all disease conditions. To shortlist the functional miRNAs in HBV-induced HCC pathogenesis, a reverse bioinformatics analysis was performed using eight GEO datasets and the TCGA database containing the list of differentially regulated mRNAs in HCC. A comparative study using these data with the identified targets of hDEmiRs, a set of unidirectionally regulated hDEmiRs with the potential to modulate mRNAs in HCC, were found. Moreover, our study identified five miRNAs; hsa-miR-98-5p, hsa-miR-193b-3p, hsa-miR-142-5p, hsa-miR-522-5p, and hsa-miR-370-3p targeting , , , , and , respectively, in HCC. These hDEmiRs and their targets could be pivotal in HBV infection and subsequent liver pathologies modulating HCC clinical progression. HBV infection is the largest contributor to HCC, and the present study comprises the first of its kind compendium of hDEmiRs related to HBV-related pathologies. - Source: PubMed
Publication date: 2024/05/31
Ramakrishnan KrishnapriyaVishwakarma RiyaDev Radul RRaju RajeshRehman Niyas - Efficient coordination between Mg and vitamin D maintains adequate Ca levels during lactation. This study explored the possible interaction between Mg (0.3, 0.8, and 3 mM) and 1,25-dihydroxyvitamin D (1,25D; 0.05 and 5 nM) during osteogenesis using bovine mesenchymal stem cells. After 21 days, differentiated osteocytes were subjected to OsteoImage analysis, alkaline phosphatase (ALP) activity measurements, and immunocytochemistry of NT5E, ENG (endoglin), SP7 (osterix), SPP1 (osteopontin), and the gene product osteocalcin. The mRNA expression of , , , , , , , , , , , , and was also assessed. Reducing the Mg concentration in the medium increased the accumulation of mineral hydroxyapatite and ALP activity. There was no change in the immunocytochemical localization of stem cell markers. Expression of was higher in all groups receiving 5 nM 1,25D. There were tendencies for higher mRNA abundance of , , and in cells receiving 0.3 mM Mg and 5 nM 1,25D. In conclusion, low levels of Mg greatly enhanced the deposition of bone hydroxyapatite matrix. The effect of Mg was not modulated by 1,25D, although the expression of certain genes (including ) tended to be increased by the combination of low Mg and high 1,25D concentrations. - Source: PubMed
Publication date: 2023/05/12
Rashid UsmanBecker Sandra KSponder GerhardTrappe SusanneSandhu Mansur AAschenbach Jörg R - Magnesium (Mg) plays an important role in various cellular functions such as protein synthesis, DNA stability, energy metabolism, enzyme and channel activities, and muscle contractility. Therefore, intracellular Mg concentration is tightly regulated by multiple Mg transporters and channels. So far, various candidate genes of Mg transporters have been identified, and the research on their structure and function is currently in progress. The Solute Carrier 41 (SLC41) family, which is related to the bacterial Mg transporter/channel MgtE, comprises three isoforms of SLC41A1, SLC41A2, and SLC41A3. Based on recent studies, SLC41A1 is thought to mediate Mg influx or Na-dependent Mg efflux across the plasma membrane, whereas SLC41A2 and SLC41A3 may mediate Mg fluxes across either the plasma membrane or organellar membranes. Intriguingly, SLC41A1 variants have been identified in patients with Parkinson's disease (PD) and nephronophthisis-related ciliopathies. Further genetic analyses reveal the association of SLC41A1 polymorphisms with PD risks. This review highlights the recent advances in the understanding of the molecular and functional characteristics of SLC41 family towards its therapeutic and diagnostic applications. - Source: PubMed
Publication date: 2022/12/14
Nemoto TakayukiTagashira HideakiKita TomoKita SatomiIwamoto Takahiro