Ask about this productRelated genes to: IBSP Blocking Peptide
- Gene:
- IBSP NIH gene
- Name:
- integrin binding sialoprotein
- Previous symbol:
- -
- Synonyms:
- BSP, SP-II, BSP-II
- Chromosome:
- 4q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-03-23
- Date modifiied:
- 2016-10-05
Related products to: IBSP Blocking Peptide
Related articles to: IBSP Blocking Peptide
- Apelin-13 plays a critical role in promoting angiogenesis and regulating cellular metabolism. However, the short half-life of Apelin-13 in vivo limits its further applications. Stem cell transplantation has been widely applied in tissue regeneration, but the low survival rate of transplanted stem cells in vivo restricts its therapeutic efficacy. This study aims to combine Apelin-13 with stem cell transplantation to enhance the survival rate of transplanted stem cells and promote bone regeneration. - Source: PubMed
Publication date: 2026/04/26
Tao JunmingQiu XiaoningFu DatianWu SiWang ZixingZhang ChiHong MengruDuan ShaochenJing Wei - Microparticles have gained significant attention as promising injectable fillers for tissue defect repair, particularly in bone regeneration. While tailoring microparticle chemistry to guide osteogenic differentiation and bone regeneration has been extensively studied, the influence of microparticle shape remains less explored. We hypothesized that, similar to chemistry, microparticle shape can modulate the osteogenic differentiation of human mesenchymal stromal cells (hMSCs). To test this, we employed a micromolding method to fabricate shape-defined microparticles from poly(lactic acid) (PLA) or PLA-nanohydroxyapatite (nHA) composites with different aspect ratios and sizes, and then co-cultured them with hMSCs to self-assemble into 3D microtissues. Microtissues containing composite microparticles showed significantly higher alkaline phosphatase activity, with high-aspect-ratio and small-sized microparticles eliciting the strongest response. Both microparticle shape and composition regulated hMSC osteogenic differentiation according to gene expression analysis. In the absence of nHA, PLA microparticles with higher aspect ratios significantly increased the expression of osteogenesis-related genes, including , , and , whereas others showed minimal effects. Introducing nHA altered this trend, with small-sized microparticles inducing the highest expression and osteopontin production at late time points. Small-sized microparticles further promoted the expression of vinculin and yes-associated protein. Furthermore, etching composite microparticles to expose nHA on their surface amplified this size-dependent effect, leading to enhanced expression of the late osteogenic marker, in hMSC microtissues containing small cube composite microparticles. Our findings establish microparticle shape, especially size and aspect ratio, as fundamental design parameters that synergize with microparticle composition to direct hMSCs toward osteogenic lineage, offering a promising strategy for engineering injectable fillers for bone regeneration. - Source: PubMed
Publication date: 2026/03/26
Song KeParvizifard MaryamBarata DavidLi JiapingTruckenmüller RomanHabibović PamelaTahmasebi Birgani Zeinab Niloofar - To evaluate the effects of cyclic tensile strain on osteogenic differentiation and angiogenic activity of mouse pericytes (PCs). - Source: PubMed
Chin Daphne YuchenTang XinyueZhao NingTang Guohua - Endochondral instead of chondral differentiation hinders mesenchymal stromal cell (MSC) application for clinical cartilage regeneration. We previously showed that heparin-polyethylene glycol (PEG) hydrogels loaded with transforming growth factor TGF-β instructed stable chondral MSC development in vivo. Here, we assessed this approach in vitro, utilizing heparin-PEG hydrogels or the pellet culture system with soluble heparin supplementation of chondrogenic medium. - Source: PubMed
Publication date: 2026/03/17
Schmidt SvenChasan SafakDietmar Helen FKlampfleuthner Felicia A MHesse ElianeWalker TilmanFreudenberg UweRichter WiltrudDiederichs Solvig - Periodontal bone regeneration remains a major challenge in in the treatment of periodontitis. This study we aimed to investigate whether there are CD169⁺ macrophages in periodontal tissues and the functions of these cells in the progressive and resolving phases of periodontitis. - Source: PubMed
Publication date: 2026/03/17
Xiong ZehuiLu JiaweiWu XiaoYang HaipengLuo Lijun