Ask about this productRelated genes to: GADL1 Blocking Peptide
- Gene:
- GADL1 NIH gene
- Name:
- glutamate decarboxylase like 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p24.1-p23
- Locus Type:
- gene with protein product
- Date approved:
- 2004-07-28
- Date modifiied:
- 2018-02-13
Related products to: GADL1 Blocking Peptide
Related articles to: GADL1 Blocking Peptide
- The flavor of chicken meat is formed by a series of complex chemical reactions, and the flavor precursors are affected by regulatory genes. In order to study the differences of muscle flavor precursors between Tengchong Snow chickens and AA broilers, integrated metabolomics and transcriptomics analyses were used to investigate muscle metabolite profiles and the key genes involved in the metabolism of muscle flavor compounds. The results showed that 42 significantly differentially metabolites were detected, and (5-L-Glutamyl)-L-glutamate, gamma-Glutamylalanine, S-Adenosylhomocysteine, Homo-L-arginine and GMP were important flavor metabolites. The key candidate genes with high correlation with flavor precursor metabolites were identified through correlation analysis as , , , , , and . In addition, the gene-metabolite interaction network for flavor formation in chicken breast muscle was constructed. This study could provide some basic data for the formation mechanism of local chicken excellent meat quality, and provide reference for the development and utilization of local chicken breeds and the selection and breeding of high-quality broilers. - Source: PubMed
Publication date: 2026/03/10
Yang MinZhang RuifangZhao JingyingJian ZonghuiWu HaoZi XiannianWang KunXu ZhiqiangGe ChangrongJia JunjingLiu LixianDou Tengfei - Sudden Unexpected Death in Epilepsy (SUDEP) refers to the unexplained, sudden death of individuals with epilepsy, and its incidence is closely linked to the severity and duration of seizures. This study aimed to identify plasma biomarkers associated with SUDEP through a combined proteomics and metabolomics approach. - Source: PubMed
Publication date: 2026/03/09
Zheng GaolinYang XinyanChen YinyuZhang PengNie Qianyun - Amino acid metabolic (AAM) reprogramming is a key characteristic of gastric cancer (GC) cells metabolic remodeling, which regulates cell growth, survival, immune cell activation and function to affect tumor immune escape. This study aims to systematically investigate AAM reprogramming in gastric cancer (GC) and construct prognostic model, and validate gene signatures for predictive value and clinical decision-making. This study leveraged data from TCGA and GEO to construct a prognostic model related to AAM and assess its clinical relevance in GC. We identified differentially expressed genes and conducted GO, GSEA, and GSVA enrichment analyses, along with constructing PPI networks and interaction networks of mRNA-miRNA, mRNA-TF, and mRNA-RBP. Additionally, immune infiltration analysis was performed and the relationships between eight hub-type amino acid metabolism-related genes (AAMRGs) and immune cells was investigated using scRNA-seq datasets. Lastly, we validated the elevated expression of these eight genes in GC cells through PCR. The study constructed a prognostic model for GC based on AAMRGs, identifying 16 key genes: ACLY, ADH4, COL1A1, F2, GADL1, GAMT, HBB, KYNU, MRI1, MTHFR, NR1D1, PDK4, SLC1A7, SLC25A15, SLC52A3, and SYCE2. Statistical analysis showed that 14 of these genes showed significant differential expression between tumor and normal tissues. Furthermore, the model demonstrated strong correlations with OS outcomes. Immune infiltration analysis indicated that various immune cell types were significantly associated with the expression of 8 hub genes, highlighting their potential role in the tumor microenvironment and immune response modulation. Furthermore, elevated expression of these genes in GC cells was validated through PCR, highlighting their relevance as potential biomarkers and therapeutic targets. Our AAMRGs prognostic model reveals AAMRGs as independent prognostic factors for GC, highlighting their association with prognosis and immune cell infiltration. These findings provide important insights for improving survival outcomes and advancing immunotherapy strategies in GC. - Source: PubMed
Publication date: 2026/03/05
Zhang HuanYe WeiZeng LingzhiWang LuGui Ling - Muscle traits are critical determinants of meat quality and productivity in sheep, influenced by both breed and anatomical region. Hanzhong sheep, an indigenous Chinese breed, are prized for tender, low-odor meat; yet, the molecular mechanisms underlying these traits remain poorly understood. In this study, we integrated meat quality assessment with metabolomic and transcriptomic profiling of the longissimus dorsi (HZ-B) and triceps brachii (HZ-T) muscles to elucidate biochemical and molecular bases of regional differences. The results, derived from metabolomic profiling, demonstrated that the muscle tissue of Hanzhong sheep contained abundant proteins (95 kinds) and fatty acids (150 kinds). The greater tenderness of HZ-B compared to HZ-T was associated with higher levels of dipeptides such as carnosine (FC = 1.07) and anserine (FC = 1.04), as well as upregulated expression of oxidative fiber-related genes MYH2 (FC = 2.92) and TPM1 (FC = 2.15). In contrast, HZ-T showed enrichment of flavor-associated metabolites, including acylcarnitines and glutamate, alongside higher expression of (FC = 0.35) and (FC = 0.47), linked to structural integrity and muscle contraction. Integrated analysis revealed strong associations between metabolite abundance (carnosine/anserine) and key genes (/), suggesting coordinated regulation of meat quality traits. These findings provide mechanistic insights into the metabolic and transcriptomic determinants of muscle quality in Hanzhong sheep, offering a foundation for genetic improvement and conservation strategies. - Source: PubMed
Publication date: 2025/09/23
Li ZhiZheng MiaohuaLi WeiweiLi JiayiWang LingWang ShanshanLu HongzhaoZhang Tao - Bivalves, such as oysters and scallops, are rich in taurine and play crucial roles in marine ecosystems as well as in aquaculture. However, mechanisms governing the taurine biosynthesis in bivalves remain poorly understood. Cysteine sulfinic acid decarboxylase (CSAD) and glutamate decarboxylase-like 1 (GADL1), as members of pyridoxal phosphate-dependent decarboxylase (PLP_deC) family, catalyze the decarboxylation step in taurine synthesis. To investigate their evolution and function in bivalves, a genome-wide identification of these genes was conducted in five bivalve species. A total of 61 PLP_deC genes were identified, of which 23 were predicted to be involved in taurine synthesis. Phylogenetic analysis revealed that these genes cluster into two distinct groups: CSAD/GADL1-like and GAD-like. Notably, bivalves possess only one Gad gene, in contrast to the two typically found in vertebrates, whereas they harbor three to five Csad/Gadl1 genes, compared with just two in vertebrates. Three bivalve Csad genes exhibited high expression levels across most of developmental stages and adult tissues, suggesting their essential roles in development and the maintenance of normal physiological activities. Molecular docking analysis revealed that oyster CSADs exhibit higher substrate-binding specificity for cysteine sulfinic acid, while GAD shows higher specificity for glutamate. Heterologous overexpression assays demonstrated that oyster CSAD and GAD can significantly increase cellular taurine levels. This study is the first to provide evidence of the expansion of Csad genes in bivalve genomes and their involvement in taurine synthesis, offering novel insights into understanding the molecular mechanisms underlying the high taurine content in bivalves. - Source: PubMed
Publication date: 2025/09/23
Pang MeiqianQi HaigangWang MinDu MingyangChen JinchengCong RihaoLi LiZhang Guofan